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    Nep5 Neprilysin 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43255, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nep5provided by FlyBase
    Official Full Name
    Neprilysin 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0039478
    Locus tag
    Dmel_CG6265
    See related
    AllianceGenome:FB:FBgn0039478
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6265; Dmel\CG6265; DmeNEP5; nep5; NEP5
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in protein processing. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult brain and spermatozoon. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nep5 in Genome Data Viewer
    Location:
    97E1-97E1; 3-92 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27057908..27064199, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22883630..22889921, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene RYamide receptor Neighboring gene uncharacterized protein Neighboring gene TweedleT Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene spatzle Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of neprilysin reduces alzheimer amyloid-beta42 (Abeta42)-induced neuron loss and intraneuronal Abeta42 deposits but causes a reduction in cAMP-responsive element-binding protein-mediated transcription, age-dependent axon pathology, and premature death in Drosophila. Iijima-Ando K, et al. J Biol Chem, 2008 Jul 4. PMID 18463098, Free PMC Article
    2. The Drosophila Neprilysin 4 gene is essential for sperm function following sperm transfer to females. Ohsako T, et al. Genes Genet Syst, 2021 Dec 16. PMID 34556622
    3. Neprilysins: an evolutionarily conserved family of metalloproteases that play important roles in reproduction in Drosophila. Sitnik JL, et al. Genetics, 2014 Mar. PMID 24395329, Free PMC Article
    4. Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster. Meyer H, et al. MicroPubl Biol, 2021 Jun 23. PMID 34189422, Free PMC Article
    5. Drosophila metalloproteases in development and differentiation: the role of ADAM proteins and their relatives. Meyer H, et al. Eur J Cell Biol, 2011 Sep. PMID 21684629

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    neprilysin 5
    Names
    CG6265-PC
    CG6265-PD
    CG6265-PE
    CG6265-PF
    Nep5-PC
    Nep5-PD
    Nep5-PE
    Nep5-PF
    NP_001097940.1
    NP_001287554.1
    NP_651527.3
    NP_733186.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27057908..27064199 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300625.1 → NP_001287554.1  neprilysin 5, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287554.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IHC6, Q9VB85
      Conserved Domains (1) summary
      cd08662
      Location:151 → 699
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I

    2. NM_170307.2 → NP_733186.2  neprilysin 5, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733186.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMQ2
      Conserved Domains (2) summary
      cd08662
      Location:151 → 880
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:146 → 882
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]

    3. NM_143270.3 → NP_651527.3  neprilysin 5, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651527.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IHC6, Q9VB85
      Conserved Domains (1) summary
      cd08662
      Location:151 → 699
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I

    4. NM_001104470.2 → NP_001097940.1  neprilysin 5, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097940.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IHC6, Q9VB85
      Conserved Domains (1) summary
      cd08662
      Location:151 → 699
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IHC6 Q8IHC6
    Q8IMQ2 Q8IMQ2
    Q95SM2 Q95SM2

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