wdb widerborst [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: wdbprovided by FlyBase
Official Full Name: widerborstprovided by FlyBase
Primary source: FLYBASE:FBgn0027492
Locus tag: Dmel_CG5643
See related: AllianceGenome:FB:FBgn0027492
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 0318/07; B56-2; BcDNA:LD34343; BEST:LD02456; CG5643; dB56-2; Dmel\CG5643; dPP2A; dPP2A-B56-2; EP3559; l(3)S031807; LD02456; PP2-AB; PP2a; PP2A; PP2A-B'; PP2A[B'-2]; wbd; Wdb; WDB; Widerborst
Summary: Predicted to enable protein phosphatase activator activity. Involved in several processes, including determination of adult lifespan; negative regulation of lipid storage; and regulation of signal transduction. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including adult head; cuboidal/columnar epithelium; embryonic/larval proventriculus; gastric caecum; and larval central nervous system. Orthologous to several human genes including PPP2R5E (protein phosphatase 2 regulatory subunit B'epsilon). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 98A6-98A8; 3-94 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (27561675..27582241, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (23387397..23407963, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Competition between two phosphatases fine-tunes Hedgehog signaling.
Title: Competition between two phosphatases fine-tunes Hedgehog signaling.
Identification of PP2A and S6 Kinase as Modifiers of Leucine-Rich Repeat Kinase-Induced Neurotoxicity.
Title: Identification of PP2A and S6 Kinase as Modifiers of Leucine-Rich Repeat Kinase-Induced Neurotoxicity.
Wdb and Wrd contribute to MEI-S332's ability to ensure accurate segregation of sister chromatids but in centromere localization, they do not act solely downstream of MEI-S332.
Title: Drosophila protein phosphatases 2A B' Wdb and Wrd regulate meiotic centromere localization and function of the MEI-S332 Shugoshin.
Studies identify PP2A-Wdb as a participant in Notch signaling, and suggest that M8 activity is controlled by phosphorylation and dephosphorylation.
Title: The Ser/Thr phosphatase PP2A regulatory subunit widerborst inhibits notch signaling.
wdb- and lkb1-dependent lifespan extension is mediated by downregulation of S6K, a downstream component of the insulin/IGF and TOR signaling pathways.
Title: A gain-of-function screen identifies wdb and lkb1 as lifespan-extending genes in Drosophila.
The protein phosphatase PP2A-B' subunit Widerborst is a negative regulator of cytoplasmic activated Akt and lipid metabolism in Drosophila
Title: The protein phosphatase PP2A-B' subunit Widerborst is a negative regulator of cytoplasmic activated Akt and lipid metabolism in Drosophila.
posttranslational mechanisms that drive cycling of PER require the rhythmic expression of PP2A (wdb and tws)
Title: Posttranslational regulation of Drosophila PERIOD protein by protein phosphatase 2A.
Planar cell polarization of wing epithelial cells requires Widerborst, a B' regulatory subunit of protein phosphatase 2A.
Title: Planar cell polarization requires Widerborst, a B' regulatory subunit of protein phosphatase 2A.
B56-associated protein phosphatase 2A is required for survival and protects from apoptosis in Drosophila melanogaster.
Title: B56-associated protein phosphatase 2A is required for survival and protects from apoptosis in Drosophila melanogaster.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein phosphatase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase type 2A complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase type 2A complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: widerborst

Names: CG5643-PA; CG5643-PB; CG5643-PC; CG5643-PD; CG5643-PE; CG5643-PF; CG5643-PH; PP2A B subunit; PP2A regulatory subunit; protein phosphatase 2a; protein phosphatase PP2A; wdb-PA; wdb-PB; wdb-PC; wdb-PD; wdb-PE; wdb-PF; wdb-PH; wiederborst

NP_001368946.1

non-AUG (AAG) translation initiation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

27561675..27582241 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_170338.3 → NP_733217.1 widerborst, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733217.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VB23, Q9Y0Y1

Related

FBpp0084574

Conserved Domains (1) summary

pfam01603
Location:50 → 448

B56; Protein phosphatase 2A regulatory B subunit (B56 family)
NM_170340.2 → NP_733219.1 widerborst, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733219.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VB23, Q9Y0Y1

Related

FBpp0084575

Conserved Domains (1) summary

pfam01603
Location:50 → 448

B56; Protein phosphatase 2A regulatory B subunit (B56 family)
NM_143312.4 → NP_651569.1 widerborst, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_651569.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VB23, Q9Y0Y1

Related

FBpp0084578

Conserved Domains (1) summary

pfam01603
Location:50 → 448

B56; Protein phosphatase 2A regulatory B subunit (B56 family)
NM_001382180.1 → NP_001368946.1 widerborst, isoform H [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A6F7R657

Conserved Domains (1) summary

pfam01603
Location:235 → 633

B56; Protein phosphatase 2A regulatory B subunit (B56 family)
NM_170337.3 → NP_733216.1 widerborst, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733216.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VB23, Q9Y0Y1

Related

FBpp0084573

Conserved Domains (1) summary

pfam01603
Location:50 → 448

B56; Protein phosphatase 2A regulatory B subunit (B56 family)
NM_170336.3 → NP_733215.1 widerborst, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733215.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VB23, Q9Y0Y1

Related

FBpp0084577

Conserved Domains (1) summary

pfam01603
Location:50 → 448

B56; Protein phosphatase 2A regulatory B subunit (B56 family)
NM_170339.3 → NP_733218.1 widerborst, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733218.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VB23, Q9Y0Y1

Related

FBpp0084579

Conserved Domains (1) summary

pfam01603
Location:50 → 448

B56; Protein phosphatase 2A regulatory B subunit (B56 family)