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    spn-F spn-F [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43700, updated on 9-Dec-2024

    Summary

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    Official Symbol
    spn-Fprovided by FlyBase
    Official Full Name
    spn-Fprovided by FlyBase
    Primary source
    FLYBASE:FBgn0086362
    Locus tag
    Dmel_CG12114
    See related
    AllianceGenome:FB:FBgn0086362
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    1130/03; CG12114; Dmel\CG12114; l(3)S113003b; Spn-F; SpnF
    Summary
    Involved in several processes, including chaeta morphogenesis; oocyte axis specification; and positive regulation of neuron remodeling. Located in Golgi apparatus. Is expressed in macrochaeta and organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See spn-F in Genome Data Viewer
    Location:
    100B8-100B9; 3-102 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31255127..31256659)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27080849..27082381)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene qless Neighboring gene mitochondrial ribosomal protein L32 Neighboring gene uncharacterized protein Neighboring gene Carbonic anhydrase 6 Neighboring gene Carbonic anhydrase 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila IKK-related kinase (Ik2) and Spindle-F proteins are part of a complex that regulates cytoskeleton organization during oogenesis. Dubin-Bar D, et al. BMC Cell Biol, 2008 Sep 17. PMID 18796167, Free PMC Article
    2. Rab11 activation by Ik2 kinase is required for dendrite pruning in Drosophila sensory neurons. Lin T, et al. PLoS Genet, 2020 Feb. PMID 32059017, Free PMC Article
    3. Drosophila oocyte polarity and cytoskeleton organization require regulation of Ik2 activity by Spn-F and Javelin-like. Amsalem S, et al. Mol Cell Biol, 2013 Nov. PMID 24019068, Free PMC Article
    4. The plus-tip tracking and microtubule stabilizing activities of Javelin-like regulate microtubule organization and cell polarity. Baskar R, et al. FEBS J, 2019 Oct. PMID 31152621
    5. Asymmetric microtubule function is an essential requirement for polarized organization of the Drosophila bristle. Bitan A, et al. Mol Cell Biol, 2010 Jan. PMID 19917727, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. findings reveal a novel regulatory mechanism for dendrite pruning achieved by temporal activation of Ik2 kinase and dynein-mediated redistribution of Ik2/Spn-F complex in neurons
      Title: Spindle-F Is the Central Mediator of Ik2 Kinase-Dependent Dendrite Pruning in Drosophila Sensory Neurons.
    2. These results suggest that polarized transport and selective retention regulate the distal tip localization of the Spn-F-IKKepsilon complex during bristle cell elongation.
      Title: A transport and retention mechanism for the sustained distal localization of Spn-F-IKKε during Drosophila bristle elongation.
    3. Spn-F mediates the interaction between Ik2 and Jvl to control Ik2 activity.
      Title: Drosophila oocyte polarity and cytoskeleton organization require regulation of Ik2 activity by Spn-F and Javelin-like.
    4. Spn-F and Ik2 are localized to the bristle tip and that mutations in ik2 and spn-F affect bristle microtubules and actin organization
      Title: Asymmetric microtubule function is an essential requirement for polarized organization of the Drosophila bristle.
    5. IkappaB kinase 2 binds physically to Spindle-F protein, biomolecular interaction analysis of Spindle-F protein and IkappaB kinase 2 demonstrating that both proteins bind directly and form a complex
      Title: The Drosophila IKK-related kinase (Ik2) and Spindle-F proteins are part of a complex that regulates cytoskeleton organization during oogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chaeta morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte anterior/posterior axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte microtubule cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in oocyte microtubule cytoskeleton polarization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuron remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of pole plasm oskar mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    spn-F
    Names
    CG12114-PA
    CG12114-PB
    Spindle-F
    lethal (3) S113003b
    spindle F
    spn-F-PA
    spn-F-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      31255127..31256659
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143601.3 → NP_651858.1  spn-F, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651858.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V9Y9
      Related
      FBpp0085122

    2. NM_001276209.1 → NP_001263138.1  spn-F, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263138.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KI68
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KI68 A0A0B4KI68
    Q9V9Y9.1 Q9V9Y9

    Gene LinkOut

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