lncRNA:Hsromega Heat shock RNA omega [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: lncRNA:Hsromegaprovided by FlyBase
Official Full Name: Heat shock RNA omegaprovided by FlyBase
Primary source: FLYBASE:FBgn0001234
Locus tag: Dmel_CR31400
See related: AllianceGenome:FB:FBgn0001234
Gene type: ncRNA
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CR31400; Dmel\CR31400; er3; hrsomega; hsr omega; hsr-omega; Hsr-omega; Hsr93D; hsromega; Hsromega; HSRomega; hsromega arcRNA; Hsromega-n; hsrw; l(3)05241; l(3)93De; l(3)er3; lncRNA-hsromega; lncRNA:hsromega; n(3)05241
Summary: Involved in several processes, including nuclear speck organization; positive regulation of JNK cascade; and regulation of protein metabolic process. Located in chromatin and omega speckle. Is expressed in several structures, including Malpighian tubule; ganglia; gland; gut section; and imaginal disc. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See lncRNA:Hsromega in Genome Data Viewer

Location:: 93D4-93D5; 3-71 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (21296127..21317836)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (17121849..17143558)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

hsromega lncRNAs in conditionally modulating the important Ras signaling pathway during R7 differentiation.
Title: Altered levels of hsromega lncRNAs further enhance Ras signaling during ectopically activated Ras induced R7 differentiation in Drosophila.
In order to obtain a clearer understanding of the role of hsromega in FUS toxicity, we herein drove the expression of human FUS in Drosophila eyes with and without a hsromega RNAi background. We found that hFUS was largely soluble and also able to form aggregates. As such, hFUS was toxic, inducing an aberrant eye morphology with the loss of pigmentation
Title: FUS toxicity is rescued by the modulation of lncRNA hsrω expression in Drosophila melanogaster.
The results suggest that the heat-shock-induced hsp70 transcripts are not destabilized by hsromega-RNAi transgene expression.
Title: Expression of hsrω-RNAi transgene prior to heat shock specifically compromises accumulation of heat shock-induced Hsp70 in Drosophila melanogaster.
variation at a polymorphic 8 bp-indel site in the heat shock hsr-omega gene that maps to the right arm of chromosome 3
Title: Thermal tolerance trade-offs associated with the right arm of chromosome 3 and marked by the hsr-omega gene in Drosophila melanogaster.
Transposon insertion in the promoter causes male sterility in insertion homozygotes.
Title: Male sterility associated with overexpression of the noncoding hsromega gene in cyst cells of testis of Drosophila melanogaster.
Significant latitudinal patterns in hsr-omega transcript level detected for both heat stimulated and non-heat stimulated flies
Title: Latitudinal clines in heat tolerance, protein synthesis rate and transcript level of a candidate gene in Drosophila melanogaster.
Hsromega-n transcripts are essential for thermotolerance and remobilization of hnRNPs, HP1 and RNA polymerase II during recovery from heat shock.
Title: The large noncoding hsrω-n transcripts are essential for thermotolerance and remobilization of hnRNPs, HP1 and RNA polymerase II during recovery from heat shock in Drosophila.
Pleiotropic consequences of misexpression of the developmentally active and stress-inducible non-coding hsr omega gene in Drosophila
Title: Pleiotropic consequences of misexpression of the developmentally active and stress-inducible non-coding hsrω gene in Drosophila.
An important function of hsr-omega is the modulation of general protein synthesis.
Title: Transcripts from the Drosophila heat-shock gene hsr-omega influence rates of protein synthesis but hardly affect resistance to heat knockdown.
direct and indirect interactions of the hsromega transcripts with a variety of regulatory proteins like hnRNPs, CBP, proteasome, Drosophila inhibitor of apoptosis protein 1 (DIAP1)
Title: Improved activities of CREB binding protein, heterogeneous nuclear ribonucleoproteins and proteasome following downregulation of noncoding hsromega transcripts help suppress poly(Q) pathogenesis in fly models.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0319 (e-PCR)
- UniSTS:35743

alternate names: heat- shock RNA omega; heat-shock RNA-omega; Heat-shock response factor-omega; Heat-shock RNA omega; heat-shock RNA ohgr; Hsr-omega; heat shock RNA omicron; hsromega; heat shock RNA omega; Hsr omega; hsr-omega; 93D locus

lncRNA:Hsromega-RA; Dmel\lncRNA:Hsromega-RA; CR31400-RA; Dmel\CR31400-RA

lncRNA:Hsromega-RB; Dmel\lncRNA:Hsromega-RB; CR31400-RB; Dmel\CR31400-RB

lncRNA:Hsromega-RC; Dmel\lncRNA:Hsromega-RC; CR31400-RC; Dmel\CR31400-RC

lncRNA:Hsromega-RD; Dmel\lncRNA:Hsromega-RD; CR31400-RD; Dmel\CR31400-RD

lncRNA:Hsromega-RF; Dmel\lncRNA:Hsromega-RF; CR31400-RF; Dmel\CR31400-RF

lncRNA:Hsromega-RG; Dmel\lncRNA:Hsromega-RG; CR31400-RG; Dmel\CR31400-RG

lncRNA:Hsromega-RH; Dmel\lncRNA:Hsromega-RH; CR31400-RH; Dmel\CR31400-RH

Gene Ontology Provided by FlyBase

Process	Evidence Code	Pubs
involved_in nuclear speck organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IPI Inferred from Physical Interaction more info	PubMed
involved_in regulation of proteolysis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in omega speckle	IDA Inferred from Direct Assay more info	PubMed