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    Act42A Actin 42A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35526, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Act42Aprovided by FlyBase
    Official Full Name
    Actin 42Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000043
    Locus tag
    Dmel_CG12051
    See related
    AllianceGenome:FB:FBgn0000043
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    42A; A; Act; act 42A; ACT2; ACT2_DROME; Act42; act42A; Act42a; ACT42A; actin; Actin; actin-42A; Actin/BAP47; AFFX-Dros-ACTIN_M_r_at; ArpB; BAP47; C; CG12051; Dmel\CG12051
    Summary
    Involved in ovarian fusome organization. Part of brahma complex. Is expressed in adult head; ganglia; gonad; gut section; and spermatozoon. Human ortholog(s) of this gene implicated in Baraitser-Winter syndrome 1; Baraitser-Winter syndrome 2; autosomal dominant nonsyndromic deafness 20; and thrombocytopenia. Orthologous to human ACTB (actin beta) and ACTG1 (actin gamma 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Act42A in Genome Data Viewer
    Location:
    42A7-42A7; 2-55 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6013910..6015689, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (1901415..1903194, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene maleless Neighboring gene Src oncogene at 42A Neighboring gene PNGase-like Neighboring gene Ser/Thr-rich caspase Neighboring gene SREBP cleavage activating protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biphasic pattern of histone gene expression during Drosophila oogenesis. Ruddell A, et al. Proc Natl Acad Sci U S A, 1985 May. PMID 3923476, Free PMC Article
    2. Non-lethal PCR genotyping of single Drosophila. Carvalho GB, et al. Biotechniques, 2009 Apr. PMID 19450239, Free PMC Article
    3. Multiple Pools of Nuclear Actin. Wineland DM, et al. Anat Rec (Hoboken), 2018 Dec. PMID 30312534, Free PMC Article
    4. Expression of a Bombyx cytoplasmic actin gene in cultured Drosophila cells: influence of 20-hydroxyecdysone and interference with expression of endogenous cytoplasmic actin genes. Abraham EG, et al. Insect Biochem Mol Biol, 1993 Dec. PMID 8220388
    5. Anti-actin immunoreactivity is retained in rhabdoms of Drosophila ninaC photoreceptors. Stowe S, et al. Cell Tissue Res, 1990 May. PMID 2372803

    See all (281) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data raise the possibility that the Drosophila embryo is divided into zones of different PTB and Notch activities based on whether or not they are linked to actin regulation.
      Title: Loss of PTB or negative regulation of Notch mRNA reveals distinct zones of Notch and actin protein accumulation in Drosophila embryo.
    2. findings show an interdependency between Hpo signaling activity and F-actin dynamics in which CP and Hpo pathway activities inhibit F-actin accumulation, and the reduction in F-actin in turn sustains Hpo pathway activity
      Title: Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila.
    3. MOESIN crosslinks this protein and cell membrane in Drosophila oocytes and is required for OSKAR anchoring.
      Title: MOESIN crosslinks actin and cell membrane in Drosophila oocytes and is required for OSKAR anchoring.
    4. essential cytoplasmic actin isoform
      Title: One of the two cytoplasmic actin isoforms in Drosophila is essential.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ovarian fusome organization IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of brahma complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    actin 42A
    Names
    42A actin
    Act42A-PA
    Actin-42A
    CG12051-PA
    F-actin
    actin
    actin42a

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6013910..6015689 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078901.3 → NP_523625.1  actin 42A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523625.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P02572, Q24228, Q540X3, Q9V9J4
      UniProtKB/TrEMBL
      C6TP14
      Related
      FBpp0085365
      Conserved Domains (1) summary
      PTZ00281
      Location:1 → 376
      PTZ00281; actin; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P02572.3 P02572

    Gene LinkOut

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