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    Ars2 Arsenic resistance protein 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35539, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ars2provided by FlyBase
    Official Full Name
    Arsenic resistance protein 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0033062
    Locus tag
    Dmel_CG7843
    See related
    AllianceGenome:FB:FBgn0033062
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.166; ars2; CG7843; Dmel\CG7843
    Summary
    Involved in defense response to Gram-negative bacterium and regulatory ncRNA-mediated gene silencing. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Orthologous to human SRRT (serrate, RNA effector molecule). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ars2 in Genome Data Viewer
    Location:
    42A9-42A9; 2-55 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6080828..6085625, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (1968333..1973130, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene SET and MYND domain containing, arthropod-specific, member 5 Neighboring gene Ecdysone receptor Neighboring gene transfer RNA:Arginine-ACG 1-1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis RNA processing factor SERRATE regulates the transcription of intronless genes. Speth C, et al. Elife, 2018 Aug 28. PMID 30152752, Free PMC Article
    2. Transposon control mechanisms in telomere biology. Kordyukova M, et al. Curr Opin Genet Dev, 2018 Apr. PMID 29571043
    3. Transcriptomic comparison of Drosophila snRNP biogenesis mutants reveals mutant-specific changes in pre-mRNA processing: implications for spinal muscular atrophy. Garcia EL, et al. RNA, 2016 Aug. PMID 27268418, Free PMC Article
    4. Mixture modeling of transcript abundance classes in natural populations. Hsieh WP, et al. Genome Biol, 2007. PMID 17547747, Free PMC Article
    5. The long and short of antiviral defense: small RNA-based immunity in insects. Bronkhorst AW, et al. Curr Opin Virol, 2014 Aug. PMID 24732439

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study identified Ars2 as a key component of Drosophila antiviral immunityp; loss of Ars2 in cells, or in flies, increases susceptibility to RNA viruses.
      Title: Ars2 regulates both miRNA- and siRNA- dependent silencing and suppresses RNA virus infection in Drosophila.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    acts_upstream_of negative regulation of viral genome replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in primary miRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in primary miRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in siRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome HDA PubMed 
    is_active_in nuclear body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    arsenic resistance protein 2
    Names
    Ars2-PA
    Ars2-PC
    Ars2-PD
    Ars2-PE
    Ars2-PF
    Ars2-PG
    CG7843-PA
    CG7843-PC
    CG7843-PD
    CG7843-PE
    CG7843-PF
    CG7843-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6080828..6085625 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273790.1 → NP_001260719.1  arsenic resistance protein 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260719.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEI5
      Conserved Domains (2) summary
      pfam04959
      Location:742 → 925
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:155 → 264
      DUF3546; Domain of unknown function (DUF3546)

    2. NM_001273791.1 → NP_001260720.1  arsenic resistance protein 2, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260720.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KF41
      Conserved Domains (1) summary
      pfam12066
      Location:155 → 199
      DUF3546; Domain of unknown function (DUF3546)

    3. NM_165460.2 → NP_724455.2  arsenic resistance protein 2, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724455.2

      Status: REVIEWED

      Conserved Domains (2) summary
      pfam04959
      Location:746 → 929
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:159 → 268
      DUF3546; Domain of unknown function (DUF3546)

    4. NM_136359.3 → NP_610203.2  arsenic resistance protein 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610203.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZ50, Q53XG1, Q8SWW6, Q95TJ0, Q9V9K7
      Related
      FBpp0085354
      Conserved Domains (2) summary
      pfam04959
      Location:746 → 896
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:159 → 268
      DUF3546; Domain of unknown function (DUF3546)

    5. NM_165459.2 → NP_724454.1  arsenic resistance protein 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724454.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZ50, Q53XG1, Q8SWW6, Q95TJ0, Q9V9K7
      Related
      FBpp0085356
      Conserved Domains (2) summary
      pfam04959
      Location:746 → 896
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:159 → 268
      DUF3546; Domain of unknown function (DUF3546)

    6. NM_165458.2 → NP_724453.1  arsenic resistance protein 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724453.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZ50, Q53XG1, Q8SWW6, Q95TJ0, Q9V9K7
      Related
      FBpp0085357
      Conserved Domains (2) summary
      pfam04959
      Location:746 → 896
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:159 → 268
      DUF3546; Domain of unknown function (DUF3546)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KEI5 A0A0B4KEI5
    A0A0B4KF41 A0A0B4KF41
    Q9V9K7.2 Q9V9K7

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