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    sut3 sugar transporter 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44268, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sut3provided by FlyBase
    Official Full Name
    sugar transporter 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0028561
    Locus tag
    Dmel_CG17976
    See related
    AllianceGenome:FB:FBgn0028561
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17976; Dmel\CG17976
    Summary
    Predicted to enable hexose transmembrane transporter activity. Involved in glucose homeostasis. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in epilepsy (multiple); glucose transporter type 1 deficiency syndrome (multiple); myelomeningocele; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including SLC2A1 (solute carrier family 2 member 1); SLC2A4 (solute carrier family 2 member 4); and SLC2A5 (solute carrier family 2 member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sut3 in Genome Data Viewer
    Location:
    44A4-44A4; 2-58 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8089482..8091297)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3976987..3978802)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene saliva Neighboring gene sugar transporter 1 Neighboring gene sugar transporter 2 Neighboring gene sandman Neighboring gene univalents only Neighboring gene Transmembrane protein 63 Neighboring gene Cullin 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of genes that influence gurken expression. Geng C, et al. Fly (Austin), 2007 Sep-Oct. PMID 18836312
    2. Circulating glucose levels inversely correlate with Drosophila larval feeding through insulin signaling and SLC5A11. Ugrankar R, et al. Commun Biol, 2018. PMID 30271990, Free PMC Article
    3. The Drosophila blood-brain barrier: development and function of a glial endothelium. Limmer S, et al. Front Neurosci, 2014. PMID 25452710, Free PMC Article
    4. Drosophila glucome screening identifies Ck1alpha as a regulator of mammalian glucose metabolism. Ugrankar R, et al. Nat Commun, 2015 May 21. PMID 25994086, Free PMC Article
    5. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hexose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monosaccharide transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sugar transporter 3
    Names
    CG17976-PA
    CG17976-PB
    sut3-PA
    sut3-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8089482..8091297
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079992.4 → NP_524731.1  sugar transporter 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524731.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KJP2, Q8T3V4
      Related
      FBpp0087857
      Conserved Domains (2) summary
      cd06174
      Location:66 → 451
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:28 → 466
      Sugar_tr; Sugar (and other) transporter

    2. NM_001273869.1 → NP_001260798.1  sugar transporter 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260798.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEF1, Q8T3V4
      Conserved Domains (1) summary
      cd06174
      Location:29 → 414
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KEF1 A0A0B4KEF1
    Q7KJP2 Q7KJP2
    Q8T3V4 Q8T3V4

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