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    l(2)03659 lethal (2) 03659 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 47905, updated on 9-Dec-2024

    Summary

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    Official Symbol
    l(2)03659provided by FlyBase
    Official Full Name
    lethal (2) 03659provided by FlyBase
    Primary source
    FLYBASE:FBgn0010549
    Locus tag
    Dmel_CG8799
    See related
    AllianceGenome:FB:FBgn0010549
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    A; CG11803; CG8799; DmCG8799; Dmel\CG8799; Dme_CG8799; hspr
    Summary
    Enables efflux transmembrane transporter activity and organic anion transmembrane transporter activity. Involved in organic anion transport. Predicted to be active in membrane. Is expressed in adult head and spermatozoon. Orthologous to human ABCC4 (ATP binding cassette subfamily C member 4 (PEL blood group)). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See l(2)03659 in Genome Data Viewer
    Location:
    45D1-45D1; 2-60 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9390165..9395281)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5277670..5282786)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 45a Neighboring gene uncharacterized protein Neighboring gene Outer dynein arm dynein axonemal light chain 1 Neighboring gene Novel nucleolar protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. eUnaG: a new ligand-inducible fluorescent reporter to detect drug transporter activity in live cells. Yeh JT, et al. Sci Rep, 2017 Feb 8. PMID 28176814, Free PMC Article
    2. The Drosophila protein Wunen repels migrating germ cells. Zhang N, et al. Nature, 1997 Jan 2. PMID 8985246
    3. Identification and genetic analysis of wunen, a gene guiding Drosophila melanogaster germ cell migration. Zhang N, et al. Genetics, 1996 Jul. PMID 8807296, Free PMC Article
    4. Drosophila protein kinase N (Pkn) is a negative regulator of actin-myosin activity during oogenesis. Ferreira T, et al. Dev Biol, 2014 Oct 15. PMID 25131196
    5. The dMRP/CG6214 gene of Drosophila is evolutionarily and functionally related to the human multidrug resistance-associated protein family. Tarnay JN, et al. Insect Mol Biol, 2004 Oct. PMID 15373810

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables efflux transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables organic anion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in organic anion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lethal (2) 03659
    Names
    CG8799-PB
    CG8799-PC
    Hsp related
    l(2)03659-PB
    l(2)03659-PC
    NP_001260823.1
    NP_610482.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9390165..9395281
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136638.4 → NP_610482.3  lethal (2) 03659, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610482.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91660, Q9V571, Q9V572
      Conserved Domains (4) summary
      cd03244
      Location:1115 → 1336
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:499 → 699
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      TIGR01271
      Location:89 → 1343
      CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
      cl00549
      Location:799 → 1045
      ABC_membrane; ABC transporter transmembrane region

    2. NM_001273894.1 → NP_001260823.1  lethal (2) 03659, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260823.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEG2
      Conserved Domains (4) summary
      cd03244
      Location:1115 → 1336
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:499 → 699
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      TIGR01271
      Location:89 → 1343
      CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
      cl00549
      Location:799 → 1045
      ABC_membrane; ABC transporter transmembrane region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KEG2 A0A0B4KEG2
    P91660.4 P91660

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