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    prel preli-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35969, updated on 9-Dec-2024

    Summary

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    Official Symbol
    prelprovided by FlyBase
    Official Full Name
    preli-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033413
    Locus tag
    Dmel_CG8806
    See related
    AllianceGenome:FB:FBgn0033413
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD36516; CG8806; Dmel\CG8806
    Summary
    Predicted to enable phosphatidic acid transfer activity. Involved in dendrite morphogenesis and mitochondrion organization. Located in mitochondrial crista. Is expressed in adult head. Orthologous to human PRELID1 (PRELI domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See prel in Genome Data Viewer
    Location:
    45D5-45D5; 2-60 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9424087..9426107)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5311592..5313612)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene wunen-2 Neighboring gene uncharacterized protein Neighboring gene Pyruvate dehydrogenase kinase Neighboring gene ced-6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel family of mitochondrial proteins is represented by the Drosophila genes slmo, preli-like and real-time. Dee CT, et al. Dev Genes Evol, 2005 May. PMID 15700158
    2. AMPK adapts metabolism to developmental energy requirement during dendrite pruning in Drosophila. Marzano M, et al. Cell Rep, 2021 Nov 16. PMID 34788610
    3. Mitochondrial protein Preli-like is required for development of dendritic arbors and prevents their regression in the Drosophila sensory nervous system. Tsubouchi A, et al. Development, 2009 Nov. PMID 19855018
    4. Mitochondrial dysfunction induces dendritic loss via eIF2α phosphorylation. Tsuyama T, et al. J Cell Biol, 2017 Mar 6. PMID 28209644, Free PMC Article
    5. Identification of a suppressor of retinal degeneration in Drosophila photoreceptors. Georgiev P, et al. J Neurogenet, 2012 Sep. PMID 23043643

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphatidic acid transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial crista IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrial intermembrane space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    preli-like
    Names
    CG8806-PB
    CG8806-PC
    Preli-like
    prel-PB
    prel-PC
    preli
    protein of relevant evolutionary and lymphoid interest-like

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9424087..9426107
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273895.1 → NP_001260824.1  preli-like, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260824.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95RE6, Q9V579
      UniProtKB/TrEMBL
      A0A0B4KEN7
      Conserved Domains (1) summary
      pfam04707
      Location:21 → 164
      PRELI; PRELI-like family

    2. NM_136643.4 → NP_610487.3  preli-like, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610487.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95RE6, Q9V579
      UniProtKB/TrEMBL
      A0A0B4KEN7
      Conserved Domains (1) summary
      pfam04707
      Location:21 → 164
      PRELI; PRELI-like family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KEN7 A0A0B4KEN7
    Q9V579.3 Q9V579

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