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    peo pendolino [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 47272, updated on 9-Dec-2024

    Summary

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    Official Symbol
    peoprovided by FlyBase
    Official Full Name
    pendolinoprovided by FlyBase
    Primary source
    FLYBASE:FBgn0288856
    Locus tag
    Dmel_CG46338
    See related
    AllianceGenome:FB:FBgn0288856
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cbx; CG10536; CG46338; Dmel\CG46338; Ft1; pen
    Summary
    Involved in defense response to bacterium and sperm individualization. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See peo in Genome Data Viewer
    Location:
    46B4-46C1; 2-61 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9864510..9875072, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5752015..5762577, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Pyruvate carboxylase Neighboring gene antisense RNA:CR44293 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45138 Neighboring gene N-terminal methyltransferase Neighboring gene Linking immunity and metabolism Neighboring gene uncharacterized protein Neighboring gene Secretory 24AB Neighboring gene antisense RNA:CR45467 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Interplay Between Developmental Stage and Environment Underlies the Adaptive Effect of a Natural Transposable Element Insertion. Merenciano M, et al. Mol Biol Evol, 2023 Mar 4. PMID 36811953, Free PMC Article
    2. Lime is a new protein linking immunity and metabolism in Drosophila. Mihajlovic Z, et al. Dev Biol, 2019 Aug 15. PMID 31085193
    3. Genetic dissection of sperm individualization in Drosophila melanogaster. Fabrizio JJ, et al. Development, 1998 May. PMID 9550716
    4. The Analysis of Pendolino (peo) Mutants Reveals Differences in the Fusigenic Potential among Drosophila Telomeres. Cenci G, et al. PLoS Genet, 2015 Jun. PMID 26110638, Free PMC Article
    5. Low dose rate γ-irradiation protects fruit fly chromosomes from double strand breaks and telomere fusions by reducing the esi-RNA biogenesis factor Loquacious. Porrazzo A, et al. Commun Biol, 2022 Sep 3. PMID 36057690, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c9870307-9870102 mobile_element_type = transposon:S{}792
    • Loc: c9870658-9870308 mobile_element_type = transposon:rooA{}3681
    • Loc: c9874665-9874431 mobile_element_type = transposon:INE-1{}3636

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables ubiquitin conjugating enzyme activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm individualization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pendolino
    Names
    CG46338-PA
    CG46338-PB
    CG46338-PC
    peo-PA
    peo-PB
    peo-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9864510..9875072 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165716.2 → NP_724848.1  pendolino, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724848.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7K4V4
      Related
      FBpp0422655
      Conserved Domains (1) summary
      cl00154
      Location:6 → 139
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    2. NM_001273908.1 → NP_001260837.1  pendolino, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260837.1

      Status: REVIEWED

      Conserved Domains (1) summary
      cl00154
      Location:6 → 99
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    3. NM_080149.4 → NP_524888.1  pendolino, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524888.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4KF51, Q7JRK3, Q7K4V4
      Related
      FBpp0422656
      Conserved Domains (2) summary
      COG5078
      Location:24 → 176
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cl00154
      Location:19 → 169
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KF51 A0A0B4KF51
    Q7K4V4.1 Q7K4V4

    Gene LinkOut

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