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    zetaTry zetaTrypsin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36216, updated on 9-Dec-2024

    Summary

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    Official Symbol
    zetaTryprovided by FlyBase
    Official Full Name
    zetaTrypsinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011556
    Locus tag
    Dmel_CG12387
    See related
    AllianceGenome:FB:FBgn0011556
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12387; Dmel\CG12387; DmZetaTry; SP110; ZetaTry; zetaTryp
    Summary
    Enables serine hydrolase activity. Predicted to be involved in proteolysis. Is expressed in organism. Orthologous to human PRSS36 (serine protease 36) and PRSS53 (serine protease 53). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See zetaTry in Genome Data Viewer
    Location:
    47F3-47F3; 2-64 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11339186..11340132, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7226691..7227637, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene lambdaTry Neighboring gene kappaTry Neighboring gene etaTrypsin Neighboring gene thetaTrypsin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Behavioural Effects and RNA-seq Analysis of Aβ42-Mediated Toxicity in a Drosophila Alzheimer's Disease Model. Tan FHP, et al. Mol Neurobiol, 2023 Aug. PMID 37145377
    2. In Drosophila Hemolymph, Serine Proteases Are the Major Gelatinases and Caseinases. Gatti JL, et al. Insects, 2024 Mar 28. PMID 38667364, Free PMC Article
    3. Concerted evolution within a trypsin gene cluster in Drosophila. Wang S, et al. Mol Biol Evol, 1999 Sep. PMID 10486967
    4. A novel interplay between the ubiquitin–proteasome system and serine proteases during Drosophila development. Lipinszki Z, et al. Biochem J, 2013 Sep 15. PMID 23805892
    5. The digestive tract of Drosophila melanogaster. Lemaitre B, et al. Annu Rev Genet, 2013. PMID 24016187

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine hydrolase activity HDA PubMed 
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zetaTrypsin
    Names
    CG12387-PA
    zetaTry-PA
    NP_523691.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      11339186..11340132 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078967.4 → NP_523691.1  zetaTrypsin [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523691.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P42280, Q9V5X8
      Related
      FBpp0087260
      Conserved Domains (2) summary
      smart00020
      Location:38 → 273
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:39 → 276
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42280.2 P42280

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