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    deltaTry deltaTrypsin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 48343, updated on 9-Dec-2024

    Summary

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    Official Symbol
    deltaTryprovided by FlyBase
    Official Full Name
    deltaTrypsinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010358
    Locus tag
    Dmel_CG12351
    See related
    AllianceGenome:FB:FBgn0010358
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12351; delta; DeltaTry; DmDeltaTry; Dmel\CG12351; endo-I; SP213; Try
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Located in cytosol. Orthologous to human PRSS36 (serine protease 36) and PRSS53 (serine protease 53). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Try the new Transcript table

    Genomic context

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    See deltaTry in Genome Data Viewer
    Location:
    47F5-47F5; 2-64 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11355319..11356128)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7242824..7243633)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Selenocysteine-TCA 1-1 Neighboring gene iotaTrypsin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A gene family in Drosophila melanogaster coding for trypsin-like enzymes. Davis CA, et al. Nucleic Acids Res, 1985 Sep 25. PMID 2414727, Free PMC Article
    2. Study on the material basis and mechanism of Hemerocallis citrina Baroni on sleep-improvement using Drosophila activity monitoring, metabolomic, targeted screening and transcriptomic. Liang Y, et al. Food Res Int, 2023 Oct. PMID 37689837
    3. The long-term effects of a life-prolonging heat treatment on the Drosophila melanogaster transcriptome suggest that heat shock proteins extend lifespan. Sarup P, et al. Exp Gerontol, 2014 Feb. PMID 24316037
    4. Concerted evolution within a trypsin gene cluster in Drosophila. Wang S, et al. Mol Biol Evol, 1999 Sep. PMID 10486967
    5. A novel interplay between the ubiquitin–proteasome system and serine proteases during Drosophila development. Lipinszki Z, et al. Biochem J, 2013 Sep 15. PMID 23805892

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    deltaTrypsin
    Names
    CG12351-PA
    deltaTry-PA
    endoproteinase I
    NP_523694.2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      11355319..11356128
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078970.4 → NP_523694.2  deltaTrypsin [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523694.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0HKA2, C0HKA3, C0HKA4, G7H855, P42276, P42277, Q8SXZ4, Q9V5Y4
      UniProtKB/TrEMBL
      G2J5V1
      Related
      FBpp0087225
      Conserved Domains (1) summary
      smart00020
      Location:30 → 249
      Tryp_SPc; Trypsin-like serine protease
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C0HKA2.1 C0HKA2
    C0HKA3.1
    C0HKA4.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials