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    stum stumble [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37473, updated on 9-Dec-2024

    Summary

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    Official Symbol
    stumprovided by FlyBase
    Official Full Name
    stumbleprovided by FlyBase
    Primary source
    FLYBASE:FBgn0050263
    Locus tag
    Dmel_CG30263
    See related
    AllianceGenome:FB:FBgn0050263
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15677; CG15679; CG30263; CT35864; Dmel\CG30263; mdcds_15969
    Summary
    Involved in proprioception; sensory perception of mechanical stimulus; and taxis. Located in sensory dendrite. Is expressed in adult leg stretch receptor neurons; adult ventral nerve cord; and leg. Orthologous to human STUM (stum, mechanosensory transduction mediator homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See stum in Genome Data Viewer
    Location:
    57F8-57F8; 2-96 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21674901..21685000)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17562406..17572505)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Negative Cofactor 2alpha Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation initiation factor 3 subunit k Neighboring gene TATA binding protein Neighboring gene Baramicin C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GABAergic inhibition of leg motoneurons is required for normal walking behavior in freely moving Drosophila. Gowda SBM, et al. Proc Natl Acad Sci U S A, 2018 Feb 27. PMID 29440493, Free PMC Article
    2. NOMPC-dependent mechanotransduction shapes the dendrite of proprioceptive neurons. Chadha A, et al. Neurosci Lett, 2015 Jun 15. PMID 25916878
    3. The stum gene is essential for mechanical sensing in proprioceptive neurons. Desai BS, et al. Science, 2014 Mar 14. PMID 24626929
    4. Identification of a new allele of O-fucosyltransferase 1 involved in Drosophila intestinal stem cell regulation. Shi L, et al. Biol Open, 2021 Nov 15. PMID 34731235, Free PMC Article
    5. Spatial Comparisons of Mechanosensory Information Govern the Grooming Sequence in Drosophila. Zhang N, et al. Curr Biol, 2020 Mar 23. PMID 32142695, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in proprioception IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proprioception IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of mechanical stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory perception of mechanical stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in taxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in taxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in sensory dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sensory dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    stumble
    Names
    CG30263-PB
    CG30263-PD
    CG30263-PE
    stum-PB
    stum-PD
    stum-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21674901..21685000
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137759.5 → NP_611603.3  stumble, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611603.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7YU83, Q9W2E1
      UniProtKB/TrEMBL
      A0A0B4KGB1
      Conserved Domains (1) summary
      pfam15795
      Location:1745 → 1833
      Spec3; Ectodermal ciliogenesis protein

    2. NM_001274196.2 → NP_001261125.2  stumble, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7YU83, Q9W2E1
      UniProtKB/TrEMBL
      A0A0B4KGB1
      Conserved Domains (1) summary
      pfam15795
      Location:1745 → 1833
      Spec3; Ectodermal ciliogenesis protein

    3. NM_001316430.1 → NP_001303359.1  stumble, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A126GUQ1
      Conserved Domains (1) summary
      pfam15795
      Location:299 → 387
      Spec3; Ectodermal ciliogenesis protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KGB1 A0A0B4KGB1
    A0A126GUQ1 A0A126GUQ1
    Q9W2E1.3 Q9W2E1

    Gene LinkOut

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