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    l(2)10685 lethal (2) 10685 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33293, updated on 9-Dec-2024

    Summary

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    Official Symbol
    l(2)10685provided by FlyBase
    Official Full Name
    lethal (2) 10685provided by FlyBase
    Primary source
    FLYBASE:FBgn0283525
    Locus tag
    Dmel_CG4749
    See related
    AllianceGenome:FB:FBgn0283525
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.81; CG4749; Dmel\CG4749
    Summary
    Predicted to enable rRNA methyltransferase activity. Predicted to be involved in rRNA methylation. Predicted to be part of mitochondrial large ribosomal subunit. Orthologous to human NSUN4 (NOP2/Sun RNA methyltransferase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See l(2)10685 in Genome Data Viewer
    Location:
    21F1-21F1; 2-2 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1147822..1149449)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1147822..1149449)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45717 Neighboring gene Major Facilitator Superfamily Transporter 3 Neighboring gene Transcription factor B4 Neighboring gene Vacuolar protein sorting 29 Neighboring gene capulet Neighboring gene antisense RNA:CR43767 Neighboring gene Transport and Golgi organization 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic screening for modifiers of the DREF pathway in Drosophila melanogaster: identification and characterization of HP6 as a novel target of DREF. Ida H, et al. Nucleic Acids Res, 2009 Apr. PMID 19136464, Free PMC Article
    2. Whole-genome analysis of dorsal-ventral patterning in the Drosophila embryo. Stathopoulos A, et al. Cell, 2002 Nov 27. PMID 12464180
    3. Automated identification of putative methyltransferases from genomic open reading frames. Katz JE, et al. Mol Cell Proteomics, 2003 Aug. PMID 12872006
    4. Phenotypes Associated with Second Chromosome P Element Insertions in Drosophila melanogaster. Kahsai L, et al. G3 (Bethesda), 2016 Aug 9. PMID 27317776, Free PMC Article
    5. The Berkeley Drosophila Genome Project gene disruption project: Single P-element insertions mutating 25% of vital Drosophila genes. Spradling AC, et al. Genetics, 1999 Sep. PMID 10471706, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial RNA modification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in rRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of mitochondrial large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    lethal (2) 10685
    Names
    CG4749-PA
    l(2)10685-PA
    NP_608573.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      1147822..1149449
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134729.3 → NP_608573.1  lethal (2) 10685 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608573.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VPX3
      Related
      FBpp0077624
      Conserved Domains (1) summary
      cl17173
      Location:283 → 499
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VPX3 Q9VPX3

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