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    cl clot [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43938, updated on 9-Dec-2024

    Summary

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    Official Symbol
    clprovided by FlyBase
    Official Full Name
    clotprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000318
    Locus tag
    Dmel_CG11024
    See related
    AllianceGenome:FB:FBgn0000318
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE06767; CG11024; Dmel\CG11024
    Summary
    Predicted to enable protein-disulfide reductase (NAD(P)H) activity. Involved in eye pigment biosynthetic process. Predicted to be active in cytosol. Is expressed in several structures, including anterior endoderm anlage; embryonic proventriculus inner layer; gut section; mesoderm; and posterior endoderm. Orthologous to human TXNDC17 (thioredoxin domain containing 17). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    25E5-25E5; 2-17 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5520135..5521382)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5520135..5521382)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45287 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44793 Neighboring gene Vacuolar protein sorting 52 Neighboring gene Elongator complex protein 4 Neighboring gene Chromosome associated protein D3 Neighboring gene Cytochrome c oxidase copper chaperone COX11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure-based analysis of Clot as a thioredoxin-related protein of 14 kDa in Drosophila via experimental and computational approaches. Kim K. Biotechnol Appl Biochem, 2018 May. PMID 29080217
    2. Interaction between pteridine synthesis and riboflavin accumulation in Drosophila melanogaster. Nickla H. Can J Genet Cytol, 1972 Mar. PMID 4624271
    3. Enzymatic conversion of dihydroneopterin triphosphate to the pyrimidodiazepine intermediate involved in the biosynthesis of the drosopterins in Drosophila melanogaster. Wiederrecht GJ, et al. J Biol Chem, 1984 Feb 25. PMID 6421807
    4. Molecular cloning and analysis of the chromosomal region 26A of Drosophila melanogaster. Knipple DC, et al. Mol Gen Genet, 1991 Apr. PMID 1903503
    5. Electrophoretic variants of alpha-glycerophosphate dehydrogenase in Drosophila melanogaster. Grell EH. Science, 1967 Dec 8. PMID 6058005

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein-disulfide reductase (NAD(P)H) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-disulfide reductase (NAD(P)H) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-disulfide reductase (NAD(P)H) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in eye pigment biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    clot
    Names
    CG11024-PA
    CG11024-PB
    CG11024-PC
    cl-PA
    cl-PB
    cl-PC
    NP_001260098.1
    NP_001260099.1
    NP_608930.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      5520135..5521382
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273169.1 → NP_001260098.1  clot, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260098.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VMQ9
      Conserved Domains (1) summary
      pfam06110
      Location:6 → 124
      DUF953; Eukaryotic protein of unknown function (DUF953)

    2. NM_001273170.1 → NP_001260099.1  clot, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260099.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VMQ9
      Conserved Domains (1) summary
      pfam06110
      Location:6 → 124
      DUF953; Eukaryotic protein of unknown function (DUF953)

    3. NM_135086.4 → NP_608930.1  clot, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608930.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VMQ9
      Related
      FBpp0078728
      Conserved Domains (1) summary
      pfam06110
      Location:6 → 124
      DUF953; Eukaryotic protein of unknown function (DUF953)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VMQ9 Q9VMQ9

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