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    Acox3 Acyl-CoA oxidase 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33898, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Acox3provided by FlyBase
    Official Full Name
    Acyl-CoA oxidase 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0031813
    Locus tag
    Dmel_CG9527
    See related
    AllianceGenome:FB:FBgn0031813
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ACOX3; CG9527; Dmel\CG9527; LCAD
    Summary
    Predicted to enable fatty acid binding activity; flavin adenine dinucleotide binding activity; and pristanoyl-CoA oxidase activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA oxidase. Predicted to be active in peroxisome. Is expressed in adult head; adult heart; embryonic/larval midgut; embryonic/larval oenocyte; and organism. Orthologous to human ACOX3 (acyl-CoA oxidase 3, pristanoyl). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Acox3 in Genome Data Viewer
    Location:
    26D1-26D4; 2-20 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6426724..6448403, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6426724..6448403, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Tiggrin Neighboring gene Fic domain-containing protein Neighboring gene real-time Neighboring gene farjavit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Endurance exercise upregulates mtp expression in aged Drosophila to ameliorate age-related diastolic dysfunction and extend lifespan. Peng T, et al. Physiol Rep, 2024 Feb. PMID 38307709, Free PMC Article
    2. miR-125-chinmo pathway regulates dietary restriction-dependent enhancement of lifespan in Drosophila. Pandey M, et al. Elife, 2021 Jun 8. PMID 34100717, Free PMC Article
    3. dSir2 deficiency in the fatbody, but not muscles, affects systemic insulin signaling, fat mobilization and starvation survival in flies. Banerjee KK, et al. Aging (Albany NY), 2012 Mar. PMID 22411915, Free PMC Article
    4. Cardiac Snail family of transcription factors directs systemic lipid metabolism in Drosophila. Liu Y, et al. PLoS Genet, 2019 Nov. PMID 31725726, Free PMC Article
    5. Retrotransposon-gene associations are widespread among D. melanogaster populations. Franchini LF, et al. Mol Biol Evol, 2004 Jul. PMID 15014149

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c6436013-6431564 mobile_element_type = transposon:roo{}315

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyl-CoA oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyl-CoA oxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables fatty acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pristanoyl-CoA oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid beta-oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in fatty acid beta-oxidation using acyl-CoA oxidase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Acyl-CoA oxidase 3
    Names
    Acox3-PA
    Acox3-PB
    Acox3-PC
    Acox3-PD
    CG9527-PA
    CG9527-PB
    CG9527-PC
    CG9527-PD
    long chain acyl-CoA-dehydrogenase
    NP_001137800.1
    NP_001260131.1
    NP_001285671.1
    NP_609027.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6426724..6448403 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298742.1 → NP_001285671.1  Acyl-CoA oxidase 3, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285671.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYT1, Q9VMD7
      Conserved Domains (1) summary
      cl09933
      Location:31 → 673
      ACAD; Acyl-CoA dehydrogenase

    2. NM_001273202.2 → NP_001260131.1  Acyl-CoA oxidase 3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260131.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYT1, Q9VMD7
      Conserved Domains (1) summary
      cl09933
      Location:31 → 673
      ACAD; Acyl-CoA dehydrogenase

    3. NM_135183.5 → NP_609027.3  Acyl-CoA oxidase 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609027.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYT1, Q9VMD7
      Related
      FBpp0088887
      Conserved Domains (1) summary
      cl09933
      Location:31 → 673
      ACAD; Acyl-CoA dehydrogenase

    4. NM_001144328.2 → NP_001137800.1  Acyl-CoA oxidase 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137800.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z028, Q8SYT1
      Conserved Domains (2) summary
      PLN02312
      Location:56 → 682
      PLN02312; acyl-CoA oxidase
      cl09933
      Location:52 → 694
      ACAD; Acyl-CoA dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7Z028 B7Z028
    Q8SYT1 Q8SYT1
    Q9VMD7 Q9VMD7

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