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    Ndae1 Na[+]-driven anion exchanger 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34005, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ndae1provided by FlyBase
    Official Full Name
    Na[+]-driven anion exchanger 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0259111
    Locus tag
    Dmel_CG42253
    See related
    AllianceGenome:FB:FBgn0259111
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    153385_at; anon-WO0257455.13; CG31906; CG42253; CG4675; Dmel\CG42253; l(2)k10316; Ndae-1; ndae1; NDAE1
    Old locus tag
    Dmel_CG31906; Dmel_CG4675
    Summary
    Enables sodium:bicarbonate symporter activity. Involved in bicarbonate transport; monoatomic ion transmembrane transport; and regulation of cellular pH. Located in plasma membrane. Is expressed in several structures, including anlage in statu nascendi; anterior-posterior subdivision of organism; epithelium; ganglia; and mesoderm. Human ortholog(s) of this gene implicated in renal tubular acidosis. Orthologous to several human genes including SLC4A10 (solute carrier family 4 member 10) and SLC4A8 (solute carrier family 4 member 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ndae1 in Genome Data Viewer
    Location:
    27E5-27E7; 2-25 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7223328..7249343, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7223328..7249343, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44989 Neighboring gene mitochondrial translation elongation factor G 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Wnt oncogene analog 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a Na+-driven anion exchanger (NDAE1). A new bicarbonate transporter. Romero MF, et al. J Biol Chem, 2000 Aug 11. PMID 10827195
    2. Localization of endogenous and recombinant Na(+)-driven anion exchanger protein NDAE1 from Drosophila melanogaster. Sciortino CM, et al. Am J Physiol Cell Physiol, 2001 Aug. PMID 11443044
    3. Inorganic and organic anion transport by insect renal epithelia. O'Donnell MJ, et al. Biochim Biophys Acta, 2003 Dec 30. PMID 14729156
    4. Mitochondrial LETM1 drives ionic and molecular clock rhythms in circadian pacemaker neurons. Morioka E, et al. Cell Rep, 2022 May 10. PMID 35545046
    5. Ndae1 expression and regulation in Drosophila embryos. Tevy MF, et al. PLoS One, 2014. PMID 24676142, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables monoatomic anion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sodium:bicarbonate symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium:bicarbonate symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables solute:inorganic anion antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in bicarbonate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in bicarbonate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chloride transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic anion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cellular pH IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of intracellular pH IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Na[+]-driven anion exchanger 1
    Names
    CG42253-PA
    CG42253-PB
    CG42253-PC
    CG42253-PD
    CG42253-PE
    CG42253-PF
    CG42253-PG
    CG42253-PH
    CG42253-PI
    CG42253-PJ
    Ndae1-PA
    Ndae1-PB
    Ndae1-PC
    Ndae1-PD
    Ndae1-PE
    Ndae1-PF
    Ndae1-PG
    Ndae1-PH
    Ndae1-PI
    Ndae1-PJ

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7223328..7249343 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273248.1 → NP_001260177.1  Na[+]-driven anion exchanger 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260177.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PB59, Q8MQK6
      Conserved Domains (3) summary
      TIGR00834
      Location:127 → 1003
      ae; anion exchange protein
      pfam00955
      Location:463 → 955
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:154 → 422
      Band_3_cyto; Band 3 cytoplasmic domain

    2. NM_001273254.1 → NP_001260183.1  Na[+]-driven anion exchanger 1, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260183.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PC95, Q8MQK6
      Conserved Domains (3) summary
      TIGR00834
      Location:71 → 1003
      ae; anion exchange protein
      pfam00955
      Location:463 → 955
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:98 → 422
      Band_3_cyto; Band 3 cytoplasmic domain

    3. NM_164743.3 → NP_723263.2  Na[+]-driven anion exchanger 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723263.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPI3, Q8MQK6
      Conserved Domains (3) summary
      TIGR00834
      Location:140 → 1016
      ae; anion exchange protein
      pfam00955
      Location:476 → 968
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:167 → 435
      Band_3_cyto; Band 3 cytoplasmic domain

    4. NM_001273249.1 → NP_001260178.1  Na[+]-driven anion exchanger 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260178.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PC92, Q8MQK6
      Conserved Domains (3) summary
      TIGR00834
      Location:127 → 1003
      ae; anion exchange protein
      pfam00955
      Location:463 → 955
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:154 → 422
      Band_3_cyto; Band 3 cytoplasmic domain

    5. NM_001273252.1 → NP_001260181.1  Na[+]-driven anion exchanger 1, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260181.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PF01, Q8MQK6
      Conserved Domains (3) summary
      TIGR00834
      Location:71 → 970
      ae; anion exchange protein
      pfam00955
      Location:430 → 922
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:98 → 389
      Band_3_cyto; Band 3 cytoplasmic domain

    6. NM_001273250.1 → NP_001260179.1  Na[+]-driven anion exchanger 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260179.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCT2, Q8MQK6
      Conserved Domains (3) summary
      TIGR00834
      Location:87 → 944
      ae; anion exchange protein
      pfam00955
      Location:404 → 896
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:114 → 363
      Band_3_cyto; Band 3 cytoplasmic domain

    7. NM_078777.3 → NP_523501.1  Na[+]-driven anion exchanger 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523501.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQK6, Q9GZG7, Q9VM32
      Related
      FBpp0288812
      Conserved Domains (3) summary
      TIGR00834
      Location:71 → 947
      ae; anion exchange protein
      pfam00955
      Location:407 → 899
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:98 → 366
      Band_3_cyto; Band 3 cytoplasmic domain

    8. NM_001273251.1 → NP_001260180.1  Na[+]-driven anion exchanger 1, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260180.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCF0, Q8MQK6
      Conserved Domains (3) summary
      TIGR00834
      Location:71 → 984
      ae; anion exchange protein
      pfam00955
      Location:444 → 936
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:98 → 403
      Band_3_cyto; Band 3 cytoplasmic domain

    9. NM_164744.2 → NP_723264.1  Na[+]-driven anion exchanger 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723264.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQK6, Q9VM31
      Related
      FBpp0288813
      Conserved Domains (3) summary
      TIGR00834
      Location:140 → 1016
      ae; anion exchange protein
      pfam00955
      Location:476 → 968
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:167 → 435
      Band_3_cyto; Band 3 cytoplasmic domain

    10. NM_001273253.1 → NP_001260182.1  Na[+]-driven anion exchanger 1, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260182.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PB60, Q8MQK6
      Conserved Domains (3) summary
      TIGR00834
      Location:140 → 1043
      ae; anion exchange protein
      pfam00955
      Location:503 → 995
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:167 → 462
      Band_3_cyto; Band 3 cytoplasmic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PB59 M9PB59
    M9PB60 M9PB60
    M9PC92 M9PC92
    M9PC95 M9PC95
    M9PCF0 M9PCF0
    M9PCT2 M9PCT2
    M9PF01 M9PF01
    Q8IPI3 Q8IPI3
    Q8MQK6 Q8MQK6
    Q9VM31 Q9VM31
    Q9VM32 Q9VM32

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