Su(var)205 Suppressor of variegation 205 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Su(var)205provided by FlyBase
Official Full Name: Suppressor of variegation 205provided by FlyBase
Primary source: FLYBASE:FBgn0003607
Locus tag: Dmel_CG8409
See related: AllianceGenome:FB:FBgn0003607
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CBX5; CG8409; dHP-1a; dHP1; dHP1a; Dmel\CG8409; DmHP-1; DmHP1; E(var)29; E(var)29A; FBgn0003607; HP-1; hp1; Hp1; HP1; HP1-VS; hp1a; Hp1a; HP1a; HP1A; HP1alpha; Su(var); Su(var)2-05; Su(var)2-5; Su(Var)2-5; Su(var)2-501; su(var)205; Su(Var)205; SU(VAR)205; Su(var)29A; Su(var)[205]; Su-var(2)5; Sur(var)205; Suvar(2)5; Suvar2-5; Su[var]205; Su[Var]205
Summary: Enables several functions, including Hsp70 protein binding activity; RNA polymerase II C-terminal domain binding activity; and nucleic acid binding activity. Involved in several processes, including positive regulation of FACT complex assembly; protein localization to euchromatin; and regulation of gene expression. Located in chromosome and nucleus. Colocalizes with polytene chromosome interband and polytene chromosome puff. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; ganglia; and gonad. Orthologous to human CBX1 (chromobox 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 28F2-28F3; 2-30 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (8209626..8211122, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (8209626..8211122, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Live analysis of position-effect variegation in Drosophila reveals different modes of action for HP1a and Su(var)3-9.
Title: Live analysis of position-effect variegation in Drosophila reveals different modes of action for HP1a and Su(var)3-9.
Complex Genetic Interactions between Piwi and HP1a in the Repression of Transposable Elements and Tissue-Specific Genes in the Ovarian Germline.
Title: Complex Genetic Interactions between Piwi and HP1a in the Repression of Transposable Elements and Tissue-Specific Genes in the Ovarian Germline.
Solvent Exposure and Ionic Condensation Drive Fuzzy Dimerization of Disordered Heterochromatin Protein Sequence.
Title: Solvent Exposure and Ionic Condensation Drive Fuzzy Dimerization of Disordered Heterochromatin Protein Sequence.
HP1 drives de novo 3D genome reorganization in early Drosophila embryos.
Title: HP1 drives de novo 3D genome reorganization in early Drosophila embryos.
NBS1 interacts with HP1 to ensure genome integrity.
Title: NBS1 interacts with HP1 to ensure genome integrity.
Ova acts to link the histone h3 lysine 4 demethylase dLsd1 to HP1a for local histone modifications.
Title: Ovaries absent links dLsd1 to HP1a for local H3K4 demethylation required for heterochromatic gene silencing.
HP1 associates differently with RNA polymerase II; HP1a and HP1b, but not HP1c, inhibit transcriptional activity, suggesting that HP1c serves as a positive regulator in transcription.
Title: Comparison of three heterochromatin protein 1 homologs in Drosophila.
HP1a maternal transcripts regulate early Drosophila embryogenesis.
Title: The Role of Maternal HP1a in Early Drosophila Embryogenesis via Regulation of Maternal Transcript Production.
we show that Heterochromatin Protein 1a is required for the production of piRNAs coming from telomeric transposable elements. Furthermore, as in adult ovaries, incomplete, bimodal, and stochastic repression resembling variegation can occur at all developmental stages
Title: From Embryo to Adult: piRNA-Mediated Silencing throughout Germline Development in Drosophila.
Knockdown of both HP1a and Mcm10 genes inhibited the progression of S phase in eye imaginal discs. Proximity Ligation Assay (PLA) demonstrated that HP1a is in close proximity to DNA replication proteins including Mcm10, RFC140 and DNA polymerase epsilon 255 kDa subunit in S-phase.
Title: Novel roles of HP1a and Mcm10 in DNA replication, genome maintenance and photoreceptor cell differentiation.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables Hsp70 protein binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II C-terminal domain binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone binding	NAS Non-traceable Author Statement more info	PubMed
enables mRNA binding	NAS Non-traceable Author Statement more info	PubMed
enables methylated histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-macromolecule adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables rDNA binding	IDA Inferred from Direct Assay more info	PubMed
enables satellite DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in chromosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterochromatin formation	HMP more info	PubMed
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in heterochromatin formation	IDA Inferred from Direct Assay more info	PubMed
involved_in heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in pericentric heterochromatin formation	HMP more info	PubMed
involved_in positive regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of FACT complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to euchromatin	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization to chromatin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in siRNA-mediated heterochromatin formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in telomere maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transposable element silencing by piRNA-mediated heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromocenter	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, centromeric region	NAS Non-traceable Author Statement more info	PubMed
located_in chromosome, telomeric region	IDA Inferred from Direct Assay more info	PubMed
located_in condensed chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in condensed chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
located_in euchromatin	IDA Inferred from Direct Assay more info	PubMed
located_in heterochromatin	IDA Inferred from Direct Assay more info	PubMed
located_in heterochromatin	NAS Non-traceable Author Statement more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in pericentric heterochromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in pericentric heterochromatin	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome chromocenter	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with polytene chromosome interband	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with polytene chromosome puff	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome puff	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: suppressor of variegation 205

Names: C1A9-nuclear-antigen; CG8409-PA; CG8409-PB; Su(var)2-5; Su(var)205-PA; Su(var)205-PB; heterochromatic protein; heterochromatic protein 1; heterochromatic protein 1a; heterochromatin factor 1; heterochromatin protein 1; heterochromatin protein 1A; heterochromatin protein-1; heterochromatin-binding protein; heterochromatin-protein-1; histone protein 1; suppressor of variegated 205

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

8209626..8211122 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057407.4 → NP_476755.1 suppressor of variegation 205, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476755.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V0F1, B6UVR4, B6UVS1, B6UVS2, B6UVS3, B6UVT2, B6UVT6, B6UVT7, P05205, Q9VLR6

Related

FBpp0079251

Conserved Domains (2) summary

smart00300
Location:141 → 202

ChSh; Chromo Shadow Domain

cd00024
Location:24 → 72

CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
NM_164799.2 → NP_723361.1 suppressor of variegation 205, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723361.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V0F1, B6UVR4, B6UVS1, B6UVS2, B6UVS3, B6UVT2, B6UVT6, B6UVT7, P05205, Q9VLR6

Related

FBpp0079252

Conserved Domains (2) summary

smart00300
Location:141 → 202

ChSh; Chromo Shadow Domain

cd00024
Location:24 → 72

CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...