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    CG4839 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34348, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4839provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032187
    Locus tag
    Dmel_CG4839
    See related
    AllianceGenome:FB:FBgn0032187
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG4839
    Summary
    Predicted to enable cGMP-dependent protein kinase activity. Predicted to be involved in signal transduction. Predicted to be located in cytoplasm and plasma membrane. Is expressed in adult brain; adult head; embryonic midgut chamber; and embryonic/larval midgut. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4839 in Genome Data Viewer
    Location:
    31A3-31A3; 2-39 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10144776..10156407)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10144776..10156407)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Sulfonylurea receptor Neighboring gene Fumarase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inhibition of diuretic stimulation of an insect secretory epithelium by a cGMP-dependent protein kinase. Ruka KA, et al. Am J Physiol Renal Physiol, 2013 May 1. PMID 23445619, Free PMC Article
    2. A kinase-dependent feedforward loop affects CREBB stability and long term memory formation. Lee PT, et al. Elife, 2018 Feb 23. PMID 29473541, Free PMC Article
    3. The Gyc76C Receptor Guanylyl Cyclase and the Foraging cGMP-Dependent Kinase Regulate Extracellular Matrix Organization and BMP Signaling in the Developing Wing of Drosophila melanogaster. Schleede J, et al. PLoS Genet, 2015 Oct. PMID 26440503, Free PMC Article
    4. Cross-species genetic screens to identify kinase targets for APP reduction in Alzheimer's disease. Huichalaf CH, et al. Hum Mol Genet, 2019 Jun 15. PMID 30753434, Free PMC Article
    5. CRISPR/Cas9 mediated genetic resource for unknown kinase and phosphatase genes in Drosophila. Wu M, et al. Sci Rep, 2020 Apr 30. PMID 32355295, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cGMP-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cGMP-dependent protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4839-PA
    CG4839-PB
    PKG-like
    NP_609349.1
    NP_723525.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10144776..10156407
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135505.3 → NP_609349.1  uncharacterized protein Dmel_CG4839, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609349.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VL34
      Related
      FBpp0079534
      Conserved Domains (4) summary
      smart00220
      Location:695 → 951
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG0664
      Location:544 → 650
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:550 → 663
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd05572
      Location:700 → 957
      STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)

    2. NM_164890.2 → NP_723525.1  uncharacterized protein Dmel_CG4839, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723525.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VL34
      Related
      FBpp0079533
      Conserved Domains (4) summary
      smart00220
      Location:695 → 951
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG0664
      Location:544 → 650
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:550 → 663
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd05572
      Location:700 → 957
      STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VL34 Q9VL34

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