RnrL Ribonucleoside diphosphate reductase large subunit [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: RnrLprovided by FlyBase
Official Full Name: Ribonucleoside diphosphate reductase large subunitprovided by FlyBase
Primary source: FLYBASE:FBgn0011703
Locus tag: Dmel_CG5371
See related: AllianceGenome:FB:FBgn0011703
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5371; Dmel\CG5371; DmRNR1; l(2)k06709; R1; RNR1; rnrL; RNRL; RnrM1; RntL
Summary: Enables cysteine-type endopeptidase activator activity involved in apoptotic process. Involved in tissue regeneration. Predicted to be part of ribonucleoside-diphosphate reductase complex. Is expressed in several structures, including CNS glial cell; embryonic/larval midgut primordium; ganglia; gut section; and mesoderm. Human ortholog(s) of this gene implicated in chronic progressive external ophthalmoplegia. Orthologous to human RRM1 (ribonucleotide reductase catalytic subunit M1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (10325026..10327943, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (10325026..10327943, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IBA Inferred from Biological aspect of Ancestor more info
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IEA Inferred from Electronic Annotation more info
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in deoxyribonucleotide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in deoxyribonucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in deoxyribonucleotide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of ribonucleoside-diphosphate reductase complex	IBA Inferred from Biological aspect of Ancestor more info

Names: CG5371-PA; RnrL-PA; ribonucleoside diphosphate reductase M1 subunit; ribonucleoside-diphosphate reductase large subunit

NP_477027.1

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The following sections contain reference sequences that belong to a specific genome build. Explain