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    Lip4 Lipase 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34450, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lip4provided by FlyBase
    Official Full Name
    Lipase 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0032264
    Locus tag
    Dmel_CG6113
    See related
    AllianceGenome:FB:FBgn0032264
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6113; dlip4; dLip4; Dmel\CG6113; lip4
    Summary
    Enables serine hydrolase activity. Predicted to be involved in lipid catabolic process. Predicted to be located in lipid droplet. Is expressed in adult head; amnioserosa; and yolk nucleus. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 8. Orthologous to human LIPK (lipase family member K); LIPM (lipase family member M); and LIPN (lipase family member N). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Lip4 in Genome Data Viewer
    Location:
    31F5-31F5; 2-43 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10527572..10531778)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10527572..10531778)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Fatty acid transport protein 1 Neighboring gene Leucine-rich repeat 47 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila transcription factor NF-Y suppresses transcription of the lipase 4 gene, a key gene for lipid storage. Yoshioka Y, et al. Exp Cell Res, 2022 Nov 1. PMID 36028059
    2. Loss of BOSS Causes Shortened Lifespan with Mitochondrial Dysfunction in Drosophila. Kohyama-Koganeya A, et al. PLoS One, 2017. PMID 28045997, Free PMC Article
    3. Death following traumatic brain injury in Drosophila is associated with intestinal barrier dysfunction. Katzenberger RJ, et al. Elife, 2015 Mar 5. PMID 25742603, Free PMC Article
    4. dFOXO regulates transcription of a Drosophila acid lipase. Vihervaara T, et al. J Mol Biol, 2008 Mar 7. PMID 18234213
    5. JNK signaling in insulin-producing cells is required for adaptive responses to stress in Drosophila. Karpac J, et al. Aging Cell, 2009 Jun. PMID 19627268, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine hydrolase activity HDA PubMed 
    enables triacylglycerol lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in lipid droplet ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    lipase 4
    Names
    CG6113-PA
    CG6113-PB
    CG6113-PC
    Lip4-PA
    Lip4-PB
    Lip4-PC
    lipase4
    NP_001188785.1
    NP_001260356.1
    NP_609418.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10527572..10531778
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273427.1 → NP_001260356.1  lipase 4, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260356.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCU5
      Conserved Domains (3) summary
      PLN02872
      Location:88 → 446
      PLN02872; triacylglycerol lipase
      pfam04083
      Location:88 → 139
      Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
      pfam12695
      Location:121 → 253
      Abhydrolase_5; Alpha/beta hydrolase family

    2. NM_001201856.2 → NP_001188785.1  lipase 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188785.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRM3
      Conserved Domains (3) summary
      PLN02872
      Location:74 → 430
      PLN02872; triacylglycerol lipase
      pfam04083
      Location:74 → 125
      Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
      pfam12695
      Location:107 → 239
      Abhydrolase_5; Alpha/beta hydrolase family

    3. NM_135574.4 → NP_609418.1  lipase 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609418.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKT9
      Related
      FBpp0079682
      Conserved Domains (3) summary
      PLN02872
      Location:74 → 432
      PLN02872; triacylglycerol lipase
      pfam04083
      Location:74 → 125
      Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
      pfam12695
      Location:107 → 239
      Abhydrolase_5; Alpha/beta hydrolase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9MRM3 M9MRM3
    M9PCU5 M9PCU5
    Q9VKT9 Q9VKT9

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