cmet CENP-meta [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: cmetprovided by FlyBase
Official Full Name: CENP-metaprovided by FlyBase
Primary source: FLYBASE:FBgn0040232
Locus tag: Dmel_CG6392
See related: AllianceGenome:FB:FBgn0040232
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Cenp-E; CENP-E; CENP-E meta; Cenp-M; Cenp-meta; CENP-Meta; CENP-META; CENPE; CENPmeta; Cenp_E; CG6392; Cmet; DmCmet; DmCmeta; Dmel\CG6392; KIF 10; KIF10; l(2)04431
Summary: Predicted to enable microtubule binding activity and plus-end-directed microtubule motor activity. Involved in mitotic metaphase chromosome alignment and regulation of cell cycle. Located in kinetochore. Is expressed in wing hinge primordium and wing pouch. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 13. Orthologous to human CENPE (centromere protein E). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 32E2-32E2; 2-44 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (11261026..11269002, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (11261026..11269002, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

kinetochores movement depends on SPC105R, can occur in the absence of NDC80, and is antagonized by plus-end directed forces from the CENP-E motor.
Title: Lateral and End-On Kinetochore Attachments Are Coordinated to Achieve Bi-orientation in Drosophila Oocytes.
Depletion of CENP-E or Nsl1-the latter mediating kinetochore targeting of Bub3-in epithelial tissues unable to activate the apoptotic program induces significant levels of aneuploidy and drives tumor-like growth.
Title: Tumor suppressor roles of CENP-E and Nsl1 in Drosophila epithelial tissues.
CENP-E appears to be required to destabilize kinetochore attachment. Activation of the mechanism that corrects inappropriate kinetochore attachment requires the antagonistic effects of BubR1 and CENP-E.
Title: BubR1 and CENP-E have antagonistic effects upon the stability of microtubule-kinetochore attachments in Drosophila S2 cell mitosis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables plus-end-directed microtubule motor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic metaphase chromosome alignment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: CENP-meta

Names: CG6392-PC; CG6392-PD; CG6392-PE; CG6392-PF; Cenp-meta; CenpMeta; Kinesin2A; cmet-PC; cmet-PD; cmet-PE; cmet-PF

NP_001260380.1

EC 5.6.1.3

NP_001260381.1

EC 5.6.1.3

NP_001260382.1

EC 5.6.1.3

NP_524993.3

EC 5.6.1.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

11261026..11269002 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001273453.1 → NP_001260382.1 CENP-meta, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260382.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PFL9, Q9NCG0

Conserved Domains (4) summary

smart00129
Location:8 → 328

KISc; Kinesin motor, catalytic domain. ATPase

COG1196
Location:625 → 1394

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cl22853
Location:8 → 321

Motor_domain; Myosin and Kinesin motor domain

pfam07851
Location:724 → 812

TMPIT; TMPIT-like protein
NM_001273451.1 → NP_001260380.1 CENP-meta, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260380.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PD87, Q9NCG0

Conserved Domains (4) summary

smart00129
Location:8 → 328

KISc; Kinesin motor, catalytic domain. ATPase

COG1196
Location:625 → 1394

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cl22853
Location:8 → 321

Motor_domain; Myosin and Kinesin motor domain

pfam07851
Location:724 → 812

TMPIT; TMPIT-like protein
NM_001273452.1 → NP_001260381.1 CENP-meta, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260381.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PCX3, Q9NCG0

Conserved Domains (5) summary

pfam05483
Location:1259 → 1925

SCP-1; Synaptonemal complex protein 1 (SCP-1)

smart00129
Location:8 → 328

KISc; Kinesin motor, catalytic domain. ATPase

COG1196
Location:680 → 1449

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cl22853
Location:8 → 321

Motor_domain; Myosin and Kinesin motor domain

pfam07851
Location:779 → 867

TMPIT; TMPIT-like protein
NM_080254.3 → NP_524993.3 CENP-meta, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524993.3

Status: REVIEWED

UniProtKB/TrEMBL

Q9NCG0, Q9VKI0

Conserved Domains (4) summary

smart00129
Location:8 → 328

KISc; Kinesin motor, catalytic domain. ATPase

COG1196
Location:680 → 1449

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cl22853
Location:8 → 321

Motor_domain; Myosin and Kinesin motor domain

pfam07851
Location:779 → 867

TMPIT; TMPIT-like protein