Vha68-1 Vacuolar H[+] ATPase 68kD subunit 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Vha68-1provided by FlyBase
Official Full Name: Vacuolar H[+] ATPase 68kD subunit 1provided by FlyBase
Primary source: FLYBASE:FBgn0265262
Locus tag: Dmel_CG12403
See related: AllianceGenome:FB:FBgn0265262
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: A subunit; ATP6V1A; CG12403; Dmel\CG12403; Vha; Vha-68-1; vha67-1; Vha68; vha68-1; VhaA
Summary: Predicted to enable proton-transporting ATPase activity, rotational mechanism. Involved in cellular response to hypoxia. Predicted to be part of vacuolar proton-transporting V-type ATPase, V1 domain. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; follicle cell; ganglia; and germline cell. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IID and developmental and epileptic encephalopathy 93. Orthologous to human ATP6V1A (ATPase H+ transporting V1 subunit A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (13000770..13004107, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (13000770..13004107, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables proton-transporting ATPase activity, rotational mechanism	IBA Inferred from Biological aspect of Ancestor more info
enables proton-transporting ATPase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ATP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proton transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in vacuolar acidification	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of proton-transporting V-type ATPase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of proton-transporting V-type ATPase, V1 domain	IEA Inferred from Electronic Annotation more info
part_of vacuolar proton-transporting V-type ATPase, V1 domain	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Names: CG12403-PA; CG12403-PB; V-ATPase V1 subunit A1; Vha68-1-PA; Vha68-1-PB; vacuolar ATPase subunit A; vacuolar H[+] ATPase subunit 68-1; vacuolar H[+]-ATPase 68; vacuolar H[+]-ATPase 68kD A subunit; vacuolar H[+]-ATPase A subunit

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