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    Ca-alpha1D Ca[2+]-channel protein alpha[[1]] subunit D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34950, updated on 2-Nov-2024

    Summary

    Official Symbol
    Ca-alpha1Dprovided by FlyBase
    Official Full Name
    Ca[2+]-channel protein alpha[[1]] subunit Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0001991
    Locus tag
    Dmel_CG4894
    See related
    AllianceGenome:FB:FBgn0001991
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    A1D; alpha1; alpha1D; BG:DS02795.1; Ca-a1D; Ca-alpha1; ca-alpha1d; ca-alpha1D; Ca-Alpha1D; Ca-alphaID; Ca-alpha[[1]]D; Ca-_1D; Ca1D; Caalpha1D; cad; CAD; caID; Ca_alpha1D; CG4894; D-type Ca[2+]; DmCa1alpha1; dmca1D; Dmca1D; DmCa1D; Dmel\CG4894; DroCa1; l(2)35Fa; l35Fa
    Summary
    Enables voltage-gated calcium channel activity. Involved in several processes, including detection of temperature stimulus involved in sensory perception of pain; epithelial fluid transport; and neuron remodeling. Located in apical plasma membrane and basolateral plasma membrane. Part of voltage-gated calcium channel complex. Is expressed in adult head; organism; presumptive embryonic/larval nervous system; and spermatozoon. Human ortholog(s) of this gene implicated in several diseases, including Brugada syndrome 3; Timothy syndrome; eye disease (multiple); hypokalemic periodic paralysis; and muscle tissue disease (multiple). Orthologous to several human genes including CACNA1C (calcium voltage-gated channel subunit alpha1 C); CACNA1F (calcium voltage-gated channel subunit alpha1 F); and CACNA1S (calcium voltage-gated channel subunit alpha1 S). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

    See Ca-alpha1D in Genome Data Viewer
    Location:
    35E5-35E6; 2-51 cM
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16165831..16190540)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16165831..16190540)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44871 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43806 Neighboring gene long non-coding RNA:CR44734 Neighboring gene long non-coding RNA:CR44735

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables high voltage-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables voltage-gated calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables voltage-gated calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables voltage-gated calcium channel activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of voltage-gated calcium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of voltage-gated calcium channel complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of voltage-gated calcium channel complex IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    part_of voltage-gated calcium channel complex NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    Ca[2+]-channel protein alpha[[1]] subunit D
    Names
    CG4894-PF
    CG4894-PG
    CG4894-PH
    CG4894-PI
    CG4894-PJ
    CG4894-PK
    CG4894-PL
    CG4894-PM
    CG4894-PN
    CG4894-PO
    Ca-alpha1D-PF
    Ca-alpha1D-PG
    Ca-alpha1D-PH
    Ca-alpha1D-PI
    Ca-alpha1D-PJ
    Ca-alpha1D-PK
    Ca-alpha1D-PL
    Ca-alpha1D-PM
    Ca-alpha1D-PN
    Ca-alpha1D-PO
    Ca2+-channel protein alpha1 subunit D
    Ca[2+]-channel alpha1 subunit
    alpha-1 subunit Ca2[+] channel type D
    calcium channel alpha-1 subunit
    drosophila melanogaster calcium channel alpha[[1]] subunit DHP-sensitive

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16165831..16190540
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273556.1NP_001260485.1  Ca[2+]-channel protein alpha[[1]] subunit D, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260485.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24270, Q8IP23, Q8IP24, Q8IP25, Q95U73, Q9V3P7
      UniProtKB/TrEMBL
      M9PDI5
      Conserved Domains (4) summary
      pfam00520
      Location:12231480
      Ion_trans; Ion transport protein
      pfam08763
      Location:15531625
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:18431924
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:14881551
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    2. NM_001273555.1NP_001260484.1  Ca[2+]-channel protein alpha[[1]] subunit D, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260484.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24270, Q8IP23, Q8IP24, Q8IP25, Q95U73, Q9V3P7
      UniProtKB/TrEMBL
      M9PD04
      Conserved Domains (4) summary
      pfam00520
      Location:11901447
      Ion_trans; Ion transport protein
      pfam08763
      Location:15201592
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:18101891
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:14551518
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    3. NM_001273552.1NP_001260481.1  Ca[2+]-channel protein alpha[[1]] subunit D, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260481.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24270, Q8IP23, Q8IP24, Q8IP25, Q95U73, Q9V3P7
      UniProtKB/TrEMBL
      M9PD78
      Conserved Domains (4) summary
      pfam00520
      Location:11871444
      Ion_trans; Ion transport protein
      pfam08763
      Location:15171589
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:18071888
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:14521515
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    4. NM_001273553.1NP_001260482.1  Ca[2+]-channel protein alpha[[1]] subunit D, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260482.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFZ4
      Conserved Domains (3) summary
      pfam00520
      Location:11871444
      Ion_trans; Ion transport protein
      pfam08763
      Location:15171589
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:14521515
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    5. NM_001273554.1NP_001260483.1  Ca[2+]-channel protein alpha[[1]] subunit D, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260483.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24270, Q8IP23, Q8IP24, Q8IP25, Q95U73, Q9V3P7
      UniProtKB/TrEMBL
      M9PBC0
      Conserved Domains (4) summary
      pfam00520
      Location:11871444
      Ion_trans; Ion transport protein
      pfam08763
      Location:15171589
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:18071888
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:14521515
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    6. NM_134429.3NP_602305.2  Ca[2+]-channel protein alpha[[1]] subunit D, isoform K [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24270, Q8IP23, Q8IP24, Q8IP25, Q95U73, Q9V3P7
      Conserved Domains (3) summary
      pfam00520
      Location:7671042
      Ion_trans; Ion transport protein
      pfam08763
      Location:21632235
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:20992152
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    7. NM_165147.2NP_723953.2  Ca[2+]-channel protein alpha[[1]] subunit D, isoform N [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24270, Q8IP23, Q8IP24, Q8IP25, Q95U73, Q9V3P7
      Conserved Domains (3) summary
      pfam00520
      Location:7671042
      Ion_trans; Ion transport protein
      pfam08763
      Location:21632235
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:20992152
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    8. NM_080365.3NP_525104.3  Ca[2+]-channel protein alpha[[1]] subunit D, isoform L [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24270, Q8IP23, Q8IP24, Q8IP25, Q95U73, Q9V3P7
      Conserved Domains (3) summary
      pfam00520
      Location:7671042
      Ion_trans; Ion transport protein
      pfam08763
      Location:21662238
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:21022155
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    9. NM_001273551.1NP_001260480.2  Ca[2+]-channel protein alpha[[1]] subunit D, isoform O [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24270, Q8IP23, Q8IP24, Q8IP25, Q95U73, Q9V3P7
      UniProtKB/TrEMBL
      M9PDI1
      Conserved Domains (3) summary
      pfam00520
      Location:7991074
      Ion_trans; Ion transport protein
      pfam08763
      Location:21922267
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:21292182
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    10. NM_165146.2NP_723952.2  Ca[2+]-channel protein alpha[[1]] subunit D, isoform M [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24270, Q8IP23, Q8IP24, Q8IP25, Q95U73, Q9V3P7
      Conserved Domains (3) summary
      pfam00520
      Location:7671042
      Ion_trans; Ion transport protein
      pfam08763
      Location:21992271
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:21352188
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated