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    Ntf-2r Nuclear transport factor-2-related [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35101, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ntf-2rprovided by FlyBase
    Official Full Name
    Nuclear transport factor-2-relatedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032680
    Locus tag
    Dmel_CG10174
    See related
    AllianceGenome:FB:FBgn0032680
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10174; Dmel\CG10174; Dntf-2; Dntf-2r; Dntf-2R
    Summary
    Predicted to enable nuclear import signal receptor activity. Predicted to be involved in protein import into nucleus. Predicted to be part of nuclear pore central transport channel. Is expressed in testis. Human ortholog(s) of this gene implicated in diabetic retinopathy. Orthologous to human NUTF2 (nuclear transport factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ntf-2r in Genome Data Viewer
    Location:
    36F5-36F5; 2-53 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18454649..18455419)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18454649..18455419)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene nucampholin Neighboring gene bicoid stability factor Neighboring gene let-7 Complex Neighboring gene mir-100 stem loop Neighboring gene let-7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Adaptive evolution of genes and gene families. Swanson WJ. Curr Opin Genet Dev, 2003 Dec. PMID 14638324
    2. Evolutionary genomics: new genes for new jobs. Presgraves DC. Curr Biol, 2005 Jan 26. PMID 15668155
    3. Relocation facilitates the acquisition of short cis-regulatory regions that drive the expression of retrogenes during spermatogenesis in Drosophila. Sorourian M, et al. Mol Biol Evol, 2014 Aug. PMID 24855141, Free PMC Article
    4. Dntf-2r, a young Drosophila retroposed gene with specific male expression under positive Darwinian selection. Betrán E, et al. Genetics, 2003 Jul. PMID 12871908, Free PMC Article
    5. Nuclear transport genes recurrently duplicate by means of RNA intermediates in Drosophila but not in other insects. Mirsalehi A, et al. BMC Genomics, 2021 Dec 5. PMID 34863092, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleocytoplasmic transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of nuclear pore central transport channel IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nuclear transport factor-2-related
    Names
    CG10174-PA
    Ntf-2r-PA
    drosophila nuclear transport factor-2-related

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      18454649..18455419
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136034.2 → NP_609878.1  nuclear transport factor-2-related [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609878.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I078, Q8I0N0, Q9VJ85
      Related
      FBpp0080616
      Conserved Domains (1) summary
      cd00780
      Location:6 → 125
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8I078 Q8I078
    Q8I0N0 Q8I0N0
    Q8I8H2 Q8I8H2
    Q9VJ85 Q9VJ85

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