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    Hr39 Hormone receptor-like in 39 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35398, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Hr39provided by FlyBase
    Official Full Name
    Hormone receptor-like in 39provided by FlyBase
    Primary source
    FLYBASE:FBgn0261239
    Locus tag
    Dmel_CG8676
    See related
    AllianceGenome:FB:FBgn0261239
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    betaFTZ-E1; CG8676; dFTZ-F1beta; DHR30; DHR39; DHR39/Ftz-F1beta; Dmel\CG8676; EP(2)2490; fs(2)04443; fs(2)neo8; FTZ-F1B; ftz-f1beta; ftz-F1beta; FTZ-F1beta; Hr-39; HR39; HR39C; i70; NR5B1
    Summary
    Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Involved in regulation of DNA-templated transcription and spermathecum morphogenesis. Located in nucleus. Is expressed in several structures, including adult fat body; dorsal epidermis primordium; epithelium; gonad; and gut section. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Hr39 in Genome Data Viewer
    Location:
    39B4-39C1; 2-54 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21237250..21259675)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21237250..21259675)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45713 Neighboring gene uncharacterized protein Neighboring gene mir-9374 stem loop Neighboring gene lethal (2) k14505 Neighboring gene mir-4974 stem loop Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Female factors modulate Sex Peptide's association with sperm in Drosophila melanogaster. Misra S, et al. BMC Biol, 2022 Dec 14. PMID 36514080, Free PMC Article
    2. The Drosophila nuclear receptors FTZ-F1 alpha and FTZ-F1 beta compete as monomers for binding to a site in the fushi tarazu gene. Ohno CK, et al. Mol Cell Biol, 1994 May. PMID 8164672, Free PMC Article
    3. FTZ-F1 beta, a novel member of the Drosophila nuclear receptor family. Ohno CK, et al. Mech Dev, 1993 Jan. PMID 8382937
    4. FTZ-Factor1 and Fushi tarazu interact via conserved nuclear receptor and coactivator motifs. Schwartz CJ, et al. EMBO J, 2001 Feb 1. PMID 11157757, Free PMC Article
    5. An evolutionary conserved interaction between the Gcm transcription factor and the SF1 nuclear receptor in the female reproductive system. Cattenoz PB, et al. Sci Rep, 2016 Nov 25. PMID 27886257, Free PMC Article

    See all (122) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The NR5A-class nuclear hormone receptor Hr39 is essential for precursor cell division and secretory unit formation in Drosophila spermathecae.
      Title: NR5A nuclear receptor Hr39 controls three-cell secretory unit formation in Drosophila female reproductive glands.
    2. We found that ftz-f1 was required for gamma neuron remodeling by activating EcR-B1 and repressing Hr39.
      Title: ftz-f1 and Hr39 opposing roles on EcR expression during Drosophila mushroom body neuron remodeling.
    3. SF1-related Drosophila nuclear hormone receptor HR39 is also essential for sexual development.
      Title: The Sf1-related nuclear hormone receptor Hr39 regulates Drosophila female reproductive tract development and function.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 21252366-21253197 mobile_element_type = transposon:HB{}484

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermathecum morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hormone receptor-like in 39
    Names
    CG8676-PA
    CG8676-PB
    CG8676-PC
    CG8676-PD
    Hr39-PA
    Hr39-PB
    Hr39-PC
    Hr39-PD
    NR5A-class nuclear hormone receptor
    fs(2)04443
    fs(2)neo8
    hormone receptor like in 39

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      21237250..21259675
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134296.3 → NP_599123.1  hormone receptor-like in 39, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_599123.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0Z2, Q05192, Q0E8N5, Q8INT8, Q9VID8
      Related
      FBpp0081008
      Conserved Domains (2) summary
      cd06930
      Location:617 → 779
      NR_LBD_F2; Ligand-binding domain of nuclear receptor family 2
      cd07167
      Location:376 → 468
      NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers

    2. NM_165364.2 → NP_724322.1  hormone receptor-like in 39, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724322.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0Z2, Q05192, Q0E8N5, Q8INT8, Q9VID8
      Related
      FBpp0081010
      Conserved Domains (2) summary
      cd06930
      Location:617 → 779
      NR_LBD_F2; Ligand-binding domain of nuclear receptor family 2
      cd07167
      Location:376 → 468
      NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers

    3. NM_057584.5 → NP_476932.1  hormone receptor-like in 39, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476932.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0Z2, Q05192, Q0E8N5, Q8INT8, Q9VID8
      Related
      FBpp0081009
      Conserved Domains (2) summary
      cd06930
      Location:617 → 779
      NR_LBD_F2; Ligand-binding domain of nuclear receptor family 2
      cd07167
      Location:376 → 468
      NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers

    4. NM_057585.3 → NP_476933.1  hormone receptor-like in 39, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476933.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q05192
      Related
      FBpp0081007
      Conserved Domains (2) summary
      cd07167
      Location:376 → 468
      NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers
      cl11397
      Location:617 → 695
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05192.3 Q05192

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