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    CG2201 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35417, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG2201provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032955
    Locus tag
    Dmel_CG2201
    See related
    AllianceGenome:FB:FBgn0032955
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG2201
    Summary
    Predicted to enable choline kinase activity and ethanolamine kinase activity. Predicted to be involved in CDP-choline pathway and phosphatidylethanolamine biosynthetic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in intellectual disability; megaconial type congenital muscular dystrophy; muscular dystrophy; narcolepsy; and recurrent hypersomnia. Orthologous to several human genes including CHKB (choline kinase beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG2201 in Genome Data Viewer
    Location:
    39E3-39E3; 2-54 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21614232..21624080, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21614232..21624080, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene no mechanoreceptor potential B Neighboring gene pseudo Neighboring gene long non-coding RNA:CR43148 Neighboring gene long non-coding RNA:CR44993 Neighboring gene Decondensation factor 31

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Intraflagellar transport is required in Drosophila to differentiate sensory cilia but not sperm. Han YG, et al. Curr Biol, 2003 Sep 30. PMID 14521833
    2. Global analysis of alternative splicing regulation by insulin and wingless signaling in Drosophila cells. Hartmann B, et al. Genome Biol, 2009. PMID 19178699, Free PMC Article
    3. Analysis of lipid droplet dynamics and functions in Drosophila melanogaster. Lee H, et al. Methods Cell Biol, 2013. PMID 24099287
    4. Anterior repression of a Drosophila stripe enhancer requires three position-specific mechanisms. Andrioli LP, et al. Development, 2002 Nov. PMID 12397102
    5. Drosophila P elements preferentially transpose to replication origins. Spradling AC, et al. Proc Natl Acad Sci U S A, 2011 Sep 20. PMID 21896744, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c21615957-21615768 mobile_element_type = transposon:INE-1{}4735
    • Loc: c21620698-21620605 mobile_element_type = transposon:INE-1{}4736
    • Loc: c21621407-21620700 mobile_element_type = transposon:INE-1{}4737
    • Loc: c21622358-21622237 mobile_element_type = transposon:INE-1{}4738

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables choline kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables choline kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ethanolamine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ethanolamine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in CDP-choline pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylcholine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phosphatidylethanolamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylethanolamine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG2201-PA
    CG2201-PB
    CG2201-PC
    CG2201-PE
    CG2201-PF
    CG2201-PG
    NP_001033931.1
    NP_001033932.2
    NP_001286125.1
    NP_610115.2
    NP_724348.1
    NP_724349.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      21614232..21624080 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001038843.3 → NP_001033932.2  uncharacterized protein Dmel_CG2201, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033932.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMF4
      Conserved Domains (1) summary
      cd05156
      Location:159 → 549
      ChoK_euk; Euykaryotic Choline Kinase

    2. NM_001299196.1 → NP_001286125.1  uncharacterized protein Dmel_CG2201, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286125.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V9R4
      Conserved Domains (1) summary
      cd05156
      Location:123 → 513
      ChoK_euk; Euykaryotic Choline Kinase

    3. NM_165386.3 → NP_724348.1  uncharacterized protein Dmel_CG2201, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724348.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V9R4
      Related
      FBpp0085275
      Conserved Domains (1) summary
      cd05156
      Location:123 → 513
      ChoK_euk; Euykaryotic Choline Kinase

    4. NM_136271.4 → NP_610115.2  uncharacterized protein Dmel_CG2201, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610115.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMF3
      Related
      FBpp0085276
      Conserved Domains (1) summary
      cd05156
      Location:20 → 410
      ChoK_euk; Euykaryotic Choline Kinase

    5. NM_165387.3 → NP_724349.1  uncharacterized protein Dmel_CG2201, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724349.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMF4
      Related
      FBpp0085277
      Conserved Domains (1) summary
      cd05156
      Location:159 → 549
      ChoK_euk; Euykaryotic Choline Kinase

    6. NM_001038842.4 → NP_001033931.1  uncharacterized protein Dmel_CG2201, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033931.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2PDP3
      Conserved Domains (1) summary
      cl21453
      Location:159 → 239
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2PDP3 Q2PDP3
    Q8IMF3 Q8IMF3
    Q8IMF4 Q8IMF4
    Q95RP0 Q95RP0
    Q9V9R4 Q9V9R4

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