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    miple2 midkine and pleiotrophin 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44787, updated on 9-Dec-2024

    Summary

    Official Symbol
    miple2provided by FlyBase
    Official Full Name
    midkine and pleiotrophin 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0029002
    Locus tag
    Dmel_CG18321
    See related
    AllianceGenome:FB:FBgn0029002
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18321; Dmel\CG18321; Miple2
    Summary
    Enables heparin binding activity. Involved in determination of adult lifespan. Located in extracellular region. Is expressed in several structures, including embryonic/larval midgut primordium; germ layer; gut section; imaginal disc; and visceral muscle primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Genomic context

    See miple2 in Genome Data Viewer
    Location:
    61B3-61B3; 3-1 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (271200..275018)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (271200..275018)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L17 Neighboring gene uncharacterized protein Neighboring gene midkine and pleiotrophin 1 Neighboring gene uncharacterized protein Neighboring gene tiny tim 2 Neighboring gene Rho guanine nucleotide exchange factor 3

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables heparin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables heparin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables heparin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mesoderm morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    midkine and pleiotrophin 2
    Names
    CG18321-PA
    CG18321-PD
    CG18321-PE
    CG18321-PF
    CG18321-PG
    Miple2
    miple2-PA
    miple2-PD
    miple2-PE
    miple2-PF
    miple2-PG

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      271200..275018
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274272.1NP_001261201.1  midkine and pleiotrophin 2, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261201.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U3W4, Q9W0S4
      Conserved Domains (1) summary
      pfam01091
      Location:156201
      PTN_MK_C; PTN/MK heparin-binding protein family, C-terminal domain
    2. NM_001274269.1NP_001261198.1  midkine and pleiotrophin 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261198.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDI0, Q9U3W4
      Conserved Domains (1) summary
      pfam01091
      Location:156201
      PTN_MK_C; PTN/MK heparin-binding protein family, C-terminal domain
    3. NM_001274270.1NP_001261199.1  midkine and pleiotrophin 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261199.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PE21, Q9U3W4
      Conserved Domains (1) summary
      pfam01091
      Location:156201
      PTN_MK_C; PTN/MK heparin-binding protein family, C-terminal domain
    4. NM_143739.3NP_651996.2  midkine and pleiotrophin 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651996.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U3W4, Q9W0S4
      Related
      FBpp0072406
      Conserved Domains (1) summary
      pfam01091
      Location:156201
      PTN_MK_C; PTN/MK heparin-binding protein family, C-terminal domain
    5. NM_001274271.1NP_001261200.1  midkine and pleiotrophin 2, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261200.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U3W4, Q9W0S4
      Conserved Domains (1) summary
      pfam01091
      Location:156201
      PTN_MK_C; PTN/MK heparin-binding protein family, C-terminal domain