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    CG12091 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38177, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG12091provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035228
    Locus tag
    Dmel_CG12091
    See related
    AllianceGenome:FB:FBgn0035228
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG12091; FBgn0035228; PPTC7
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in regulation of ubiquinone biosynthetic process. Predicted to be active in mitochondrion. Is expressed in several structures, including anterior endoderm; dorsal pharyngeal muscle cell; embryonic anal pad; embryonic/larval midgut primordium; and mesoderm. Orthologous to human PPTC7 (protein phosphatase targeting COQ7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG12091 in Genome Data Viewer
    Location:
    62A3-62A3; 3-0.5 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1534929..1536835, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1534929..1536835, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Puromycin sensitive aminopeptidase Neighboring gene cueball Neighboring gene Increased minichromosome loss 1 Neighboring gene Ionotropic receptor 62a Neighboring gene pinstripe Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic and genomewide analyses suggest a functional relationship between kayak, the Drosophila fos homolog, and fig, a predicted protein phosphatase 2c nested within a kayak intron. Hudson SG, et al. Genetics, 2007 Nov. PMID 18039871, Free PMC Article
    2. The mitochondrial phosphatase PPTC7 orchestrates mitochondrial metabolism regulating coenzyme Q(10) biosynthesis. González-Mariscal I, et al. Biochim Biophys Acta Bioenerg, 2018 Nov. PMID 30267671
    3. Transgenic Drosophila lines for LexA-dependent gene and growth regulation. Chang KR, et al. G3 (Bethesda), 2022 Mar 4. PMID 35100369, Free PMC Article
    4. Genome-wide RNAi screening implicates the E3 ubiquitin ligase Sherpa in mediating innate immune signaling by Toll in Drosophila adults. Kanoh H, et al. Sci Signal, 2015 Oct 27. PMID 26508789
    5. Behavioral screening of sleep-promoting effects of human intestinal and food-associated bacteria on Drosophila melanogaster. Ko T, et al. Genes Cells, 2023 Jun. PMID 36914986, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphoprotein phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of ubiquinone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG12091-PA
    CG12091-PB
    NP_001261261.1
    NP_647619.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1534929..1536835 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274332.1 → NP_001261261.1  uncharacterized protein Dmel_CG12091, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261261.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W0E2
      Conserved Domains (1) summary
      cl00120
      Location:76 → 316
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

    2. NM_139362.3 → NP_647619.1  uncharacterized protein Dmel_CG12091, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647619.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W0E2
      Related
      FBpp0072711
      Conserved Domains (1) summary
      cl00120
      Location:76 → 316
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W0E2 Q9W0E2

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