Patj patj [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Patjprovided by FlyBase
Official Full Name: patjprovided by FlyBase
Primary source: FLYBASE:FBgn0067864
Locus tag: Dmel_CG12021
See related: AllianceGenome:FB:FBgn0067864
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:LD22238; CG12021; D-Patj; dlt; Dlt; DLT; dlt:discs lost; Dmel\CG12021; dpatj; dPatj; dPATJ; Dpatj; DPatj; DPATJ; patj; PatJ; PaTJ; PATJ; Patj/Dlt
Summary: Enables myosin II light chain binding activity; myosin phosphatase regulator activity; and protein kinase C binding activity. Involved in several processes, including morphogenesis of an epithelium; photoreceptor cell maintenance; and photoreceptor cell morphogenesis. Located in adherens junction; apical plasma membrane; and apicolateral plasma membrane. Part of subapical complex. Colocalizes with plasma membrane. Is expressed in several structures, including adult head; embryonic/larval salivary gland; epithelial cell; epithelium; and larval optic anlage. Human ortholog(s) of this gene implicated in hydrocephalus. Orthologous to human PATJ (PATJ crumbs cell polarity complex component) and MPDZ (multiple PDZ domain crumbs cell polarity complex component). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 62B4-62B4; 3-1.0 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (1798803..1802184)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (1798803..1802184)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The weakening of adherens junction(AJ) in a PATJ mutant epithelium led first to a loss of Myosin from the AJ, subsequently to a disassembly of the AJ, and finally, to a loss of apical-basal polarity and disruption of the tissue.
Title: Drosophila PATJ supports adherens junction stability by modulating Myosin light chain activity.
The only crucial function of Patj hinges on the ability of its first two domains to positively regulate the Crumbs complex, defining a new developmental level of regulation of its dynamics.
Title: Tissue-specific function of Patj in regulating the Crumbs complex and epithelial polarity.
dPatj possesses an as yet unidentified function that is essential for pupal development.
Title: Drosophila Patj plays a supporting role in apical-basal polarity but is essential for viability.
Has domain-specific early and late functions in regulating the localization and stability of the Crb-Sdt complex in photoreceptor cells.
Title: Domain-specific early and late function of Dpatj in Drosophila photoreceptor cells.
dlt is not required for cell polarity but is needed for cell survival and cell cycle progression.
Title: The Drosophila cell survival gene discs lost encodes a cytoplasmic Codanin-1-like protein, not a homolog of tight junction PDZ protein Patj.
Patj plays a role in retinal morphogenesis and protects against light-dependent degeneration of photoreceptor cells.
Title: DPATJ plays a role in retinal morphogenesis and protects against light-dependent degeneration of photoreceptor cells in the Drosophila eye.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

Dm0170 (e-PCR)
- UniSTS:49942

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables myosin II light chain binding	IDA Inferred from Direct Assay more info	PubMed
enables myosin phosphatase regulator activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein kinase C binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in adherens junction maintenance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in adherens junction organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apical protein localization	TAS Traceable Author Statement more info	PubMed
involved_in cell-cell junction assembly	NAS Non-traceable Author Statement more info	PubMed
involved_in establishment of planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of apical/basal cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in establishment or maintenance of neuroblast polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of polarity of embryonic epithelium	TAS Traceable Author Statement more info	PubMed
involved_in establishment or maintenance of polarity of follicular epithelium	IPI Inferred from Physical Interaction more info	PubMed
involved_in morphogenesis of an epithelium	TAS Traceable Author Statement more info	PubMed
involved_in morphogenesis of follicular epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pupal development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in apical cortex	NAS Non-traceable Author Statement more info	PubMed
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	NAS Non-traceable Author Statement more info	PubMed
located_in apicolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in nuclear envelope	NAS Non-traceable Author Statement more info	PubMed
colocalizes_with plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed
located_in septate junction	TAS Traceable Author Statement more info	PubMed
part_of subapical complex	IDA Inferred from Direct Assay more info	PubMed
part_of subapical complex	TAS Traceable Author Statement more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: patj

Names: CG12021-PA; CG12021-PB; CG12021-PC; Patj-PA; Patj-PB; Patj-PC; discs lost; discslost

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

1798803..1802184

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057994.5 → NP_477342.1 patj, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477342.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9NB04, Q9UA56, Q9XZ35

UniProtKB/TrEMBL

A4V1B2

Related

FBpp0072662

Conserved Domains (2) summary

cd00992
Location:318 → 400

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl02672
Location:12 → 70

L27; L27 domain
NM_134317.4 → NP_599144.1 patj, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_599144.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9NB04, Q9UA56, Q9XZ35

UniProtKB/TrEMBL

A4V1B2

Related

FBpp0290839

Conserved Domains (2) summary

cd00992
Location:318 → 400

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl02672
Location:12 → 70

L27; L27 domain
NM_167917.4 → NP_728674.1 patj, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728674.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9NB04, Q9UA56, Q9XZ35

UniProtKB/TrEMBL

A4V1B2

Related

FBpp0072664

Conserved Domains (2) summary

cd00992
Location:318 → 400

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl02672
Location:12 → 70

L27; L27 domain