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    CG12016 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38411, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG12016provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035436
    Locus tag
    Dmel_CG12016
    See related
    AllianceGenome:FB:FBgn0035436
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG12016; dNrk; Dromel_CG12016_FBtr0073063_mORF
    Summary
    Predicted to enable ribosylnicotinamide kinase activity. Predicted to be involved in nicotinamide riboside metabolic process. Predicted to be active in cytoplasm. Is expressed in organism. Orthologous to several human genes including NMRK2 (nicotinamide riboside kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG12016 in Genome Data Viewer
    Location:
    63D1-63D1; 3-8 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3319555..3322489)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3319555..3322489)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Drosomycin-like 5 Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class C Neighboring gene Dolichyl-phosphate mannosyltransferase subunit 2 Neighboring gene Striatin interacting protein Neighboring gene Glutathione peroxidase homolog with thioredoxin peroxidase activity Neighboring gene long non-coding RNA:CR45380

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The NAD(+) precursor NMN activates dSarm to trigger axon degeneration in Drosophila. Llobet Rosell A, et al. Elife, 2022 Dec 23. PMID 36476387, Free PMC Article
    2. Drosophila Strip serves as a platform for early endosome organization during axon elongation. Sakuma C, et al. Nat Commun, 2014 Oct 14. PMID 25312435, Free PMC Article
    3. Exhaustive identification of conserved upstream open reading frames with potential translational regulatory functions from animal genomes. Takahashi H, et al. Sci Rep, 2020 Oct 1. PMID 33004976, Free PMC Article
    4. Comparative genomic analysis of novel conserved peptide upstream open reading frames in Drosophila melanogaster and other dipteran species. Hayden CA, et al. BMC Genomics, 2008 Feb 1. PMID 18237443, Free PMC Article
    5. Comparative transcriptomic analysis of human and Drosophila extracellular vesicles. Lefebvre FA, et al. Sci Rep, 2016 Jun 10. PMID 27282340, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ribosylnicotinamide kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosylnicotinamide kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in nicotinamide riboside metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG12016-PA
    CG12016-PB
    NP_647805.1
    NP_728865.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3319555..3322489
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139548.4 → NP_647805.1  uncharacterized protein Dmel_CG12016, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647805.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95SV2, Q9VZR0
      Related
      FBpp0072927
      Conserved Domains (1) summary
      cd02024
      Location:6 → 255
      NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...

    2. NM_168022.2 → NP_728865.1  uncharacterized protein Dmel_CG12016, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728865.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95SV2, Q9VZR0
      Related
      FBpp0072928
      Conserved Domains (1) summary
      cd02024
      Location:6 → 255
      NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VZR0 Q9VZR0

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