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    ImpL2 Ecdysone-inducible gene L2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38513, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ImpL2provided by FlyBase
    Official Full Name
    Ecdysone-inducible gene L2provided by FlyBase
    Primary source
    FLYBASE:FBgn0001257
    Locus tag
    Dmel_CG15009
    See related
    AllianceGenome:FB:FBgn0001257
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15009; CT34862; Dmel\CG15009; GH28; Imp-12; imp-L2; Imp-L2; IMP-L2; ImpL-2; impl2; impL2; Impl2; IMPL2
    Summary
    Enables insulin binding activity. Involved in several processes, including determination of adult lifespan; positive regulation of entry into reproductive diapause; and regulation of insulin receptor signaling pathway. Located in extracellular space. Is expressed in several structures, including CNS glial cell; anterior-posterior subdivision of organism; follicle cell; gut section; and imaginal disc. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See ImpL2 in Genome Data Viewer
    Location:
    64A10-64A10; 3-10 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4224006..4236147, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4224006..4236147, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Cuticular protein 64Ad Neighboring gene antisense RNA:CR32252 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45738 Neighboring gene Sulfide quinone oxidoreductase Neighboring gene pavarotti

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cross-Linking/Mass Spectrometry Uncovers Details of Insulin-Like Growth Factor Interaction With Insect Insulin Binding Protein Imp-L2. Pompach P, et al. Front Endocrinol (Lausanne), 2019. PMID 31649623, Free PMC Article
    2. The Continuing Evolution of Insulin-like Growth Factor Signaling. Rosenzweig SA. F1000Res, 2020. PMID 32226608, Free PMC Article
    3. Fat body glycolysis defects inhibit mTOR and promote distant muscle disorganization through TNF-α/egr and ImpL2 signaling in Drosophila larvae. Rodríguez-Vázquez M, et al. EMBO Rep, 2024 Oct. PMID 39251827, Free PMC Article
    4. Genes expressed during imaginal discs morphogenesis: IMP-L2, a gene expressed during imaginal disc and imaginal histoblast morphogenesis. Osterbur DL, et al. Dev Biol, 1988 Oct. PMID 2843403
    5. A new secreted insect protein belonging to the immunoglobulin superfamily binds insulin and related peptides and inhibits their activities. Sloth Andersen A, et al. J Biol Chem, 2000 Jun 2. PMID 10748036

    See all (237) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fat body glycolysis defects inhibit mTOR and promote distant muscle disorganization through TNF-alpha/egr and ImpL2 signaling in Drosophila larvae.
      Title: Fat body glycolysis defects inhibit mTOR and promote distant muscle disorganization through TNF-α/egr and ImpL2 signaling in Drosophila larvae.
    2. Piwi expressed in Drosophila adipose tissues regulates systemic IGF signaling and growth via IGF-binding protein.
      Title: Piwi expressed in Drosophila adipose tissues regulates systemic IGF signaling and growth via IGF-binding protein.
    3. Macrophage-derived insulin antagonist ImpL2 induces lipoprotein mobilization upon bacterial infection.
      Title: Macrophage-derived insulin antagonist ImpL2 induces lipoprotein mobilization upon bacterial infection.
    4. Sustained Nrf2 Overexpression-Induced Metabolic Deregulation Can Be Attenuated by Modulating Insulin/Insulin-like Growth Factor Signaling.
      Title: Sustained Nrf2 Overexpression-Induced Metabolic Deregulation Can Be Attenuated by Modulating Insulin/Insulin-like Growth Factor Signaling.
    5. Tumors overcome the action of the wasting factor ImpL2 by locally elevating Wnt/Wingless.
      Title: Tumors overcome the action of the wasting factor ImpL2 by locally elevating Wnt/Wingless.
    6. beta-sheet fold serves as a direct, high-affinity binder of hormones; likely represents an alternative hormone binding and regulatory IBP system different and evolutionarily independent from human IGFBPs
      Title: Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones.
    7. Increased expression of ImpL2 is associated with cachexia-like wasting.
      Title: Malignant Drosophila tumors interrupt insulin signaling to induce cachexia-like wasting.
    8. Increased expression of the secreted insulin/IGF antagonist ImpL2 is associated with organ wasting.
      Title: Systemic organ wasting induced by localized expression of the secreted insulin/IGF antagonist ImpL2.
    9. Imp-L2-expressing neurons sense the nutritional state of Drosophila larvae and coordinate dietary information and ecdysone production to adjust developmental timing under starvation conditions
      Title: Local requirement of the Drosophila insulin binding protein imp-L2 in coordinating developmental progression with nutritional conditions.
    10. role in the longevity
      Title: Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cell-cell adhesion mediator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables insulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables insulin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dendrite self-avoidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of insulin receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of entry into reproductive diapause IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to insect IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ecdysone-inducible gene L2
    Names
    CG15009-PA
    CG15009-PB
    CG15009-PC
    CG15009-PD
    ImpL2-PA
    ImpL2-PB
    ImpL2-PC
    ImpL2-PD
    ecdysone-inducible gene L2
    imaginal morphogenesis protein-late 2
    neural and ectodermal development factor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4224006..4236147 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274480.1 → NP_001261409.1  Ecdysone-inducible gene L2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261409.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEL7, Q3YMW0
      Conserved Domains (1) summary
      smart00408
      Location:183 → 247
      IGc2; Immunoglobulin C-2 Type

    2. NM_079197.5 → NP_523921.3  Ecdysone-inducible gene L2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523921.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q3YMW0
      Related
      FBpp0073104
      Conserved Domains (1) summary
      smart00408
      Location:186 → 250
      IGc2; Immunoglobulin C-2 Type

    3. NM_168069.2 → NP_728960.1  Ecdysone-inducible gene L2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728960.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEL7, Q3YMW0
      Related
      FBpp0073105
      Conserved Domains (1) summary
      smart00408
      Location:183 → 247
      IGc2; Immunoglobulin C-2 Type

    4. NM_168070.2 → NP_728961.2  Ecdysone-inducible gene L2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728961.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09024, Q6NLN1, Q7KV52, Q95SU7, Q9VZF7
      UniProtKB/TrEMBL
      Q3YMW0
      Related
      FBpp0073106
      Conserved Domains (1) summary
      smart00408
      Location:187 → 251
      IGc2; Immunoglobulin C-2 Type
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PEL7 M9PEL7
    Q09024.4 Q09024
    Q24364 Q24364
    Q24365 Q24365
    Q24366 Q24366
    Q3YMW0 Q3YMW0

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