lin-28 lin-28 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: lin-28provided by FlyBase
Official Full Name: lin-28provided by FlyBase
Primary source: FLYBASE:FBgn0035626
Locus tag: Dmel_CG17334
See related: AllianceGenome:FB:FBgn0035626
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:RE05342; CG17334; Dmel\CG17334; EP(3)0915; Lin-28; LIN-28; lin28; Lin28; LIN28B
Summary: Enables mRNA 3'-UTR binding activity. Involved in several processes, including germ-line stem-cell niche homeostasis; positive regulation of gene expression; and positive regulation of signal transduction. Located in cytoplasmic stress granule and cytosol. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; head epidermis primordium; somatic precursor cell; and visceral mesoderm derivative. Orthologous to several human genes including LIN28A (lin-28 homolog A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 64E1-64E1; 3-15 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (5654681..5657384)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (5647781..5650484)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

reduction in old testis leads to decreased upd levels, hub cell aging, and loss of the stem cell niche
Title: Lin28 is a critical factor in the function and aging of Drosophila testis stem cell niche.
Lin-28 does not block the production of let-7 in Drosophila, which suggests the let-7 independent pathway as a molecular mechanism of Lin-28
Title: In-depth study of lin-28 suggests selectively conserved let-7 independent mechanism in Drosophila.
This FMRP activity is mediated solely via a second conserved RNA-binding protein, LIN-28, known to boost insulin signaling in stem cells. Via LIN-28, FMRP controls progenitor cell behavior by post-transcriptionally repressing the level of insulin receptor (InR).
Title: Opposing Post-transcriptional Control of InR by FMRP and LIN-28 Adjusts Stem Cell-Based Tissue Growth.
Based on the analyses authors' current view is that LIN-28 is an essential component of an intestinal progenitor-specific ribonucleoprotein (RNP) complex that modulates stem cell division type to adjust tissue growth to dietary conditions.
Title: Starving for more: Nutrient sensing by LIN-28 in adult intestinal progenitor cells.
Lin-28 is a stem cell intrinsic factor that boosts insulin signaling in intestinal progenitor cells and promotes their symmetric division in response to nutrients
Title: Lin-28 promotes symmetric stem cell division and drives adaptive growth in the adult Drosophila intestine.
microRNA regulation is a conserved feature of the Lin-28 gene in diverse animals.
Title: Conservation of the heterochronic regulator Lin-28, its developmental expression and microRNA complementary sites.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA stabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in germ-line stem-cell niche homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of pre-miRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-embryonic digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-transcriptional regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pre-miRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in symmetric stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: lin-28

Names: CG17334-PA; Lin28; lin-28-PA

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

5654681..5657384

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_139726.2 → NP_647983.1 lin-28 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_647983.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VRN5

Related

FBpp0076798

Conserved Domains (1) summary

cd04458
Location:41 → 101

CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...