U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    Prim1 DNA primase subunit 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38942, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Prim1provided by FlyBase
    Official Full Name
    DNA primase subunit 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0011762
    Locus tag
    Dmel_CG7108
    See related
    AllianceGenome:FB:FBgn0011762
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.257; CG7108; Dmel\CG7108; Dmpol alpha; DNA polalpha; dnapol alpha 50; DNApol-alpha; DNApol-alpha50; DNApolalpha; DNApolalpha-50; DNApolalpha50; Dpri50; Pol; pol alpha; Pol-alpha50; POLA; polalpha; Polalpha; Polalpha 50kDa; Polalpha 50KDa; polalpha50; Polalpha50; PRI1
    Summary
    Enables DNA primase activity. Involved in DNA replication, synthesis of primer. Part of alpha DNA polymerase:primase complex. Orthologous to human PRIM1 (DNA primase subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Prim1 in Genome Data Viewer
    Location:
    66C7-66C8; 3-24 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8340314..8344404)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8333414..8337504)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Cuticular protein 66Cb Neighboring gene Peroxin 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene GTPase activating protein and centrosome-associated

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The 50-kDa primase subunit of Drosophila melanogaster DNA polymerase alpha. Molecular characterization of the gene and functional analysis of the overexpressed protein. Bakkenist CJ, et al. J Biol Chem, 1994 Oct 28. PMID 7929411
    2. Recollections of a DNA enzymologist. Lehman IR. Protein Sci, 1998 Apr. PMID 9568914, Free PMC Article
    3. Elongation of RNA-primed DNA templates by DNA polymerase alpha from Drosophila melanogaster embryos. Villani G, et al. J Biol Chem, 1981 Aug 10. PMID 6790535
    4. DNA polymerase alpha from Drosophila melanogaster embryos. Subunit structure. Villani G, et al. J Biol Chem, 1980 Oct 10. PMID 6773966
    5. Synthesis by the DNA primase of Drosophila melanogaster of a primer with a unique chain length. Conaway RC, et al. Proc Natl Acad Sci U S A, 1982 Aug. PMID 6812052, Free PMC Article

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA primase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA primase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA primase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication, synthesis of primer IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication, synthesis of primer IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA replication, synthesis of primer IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated DNA replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of alpha DNA polymerase:primase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of alpha DNA polymerase:primase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    DNA primase subunit 1
    Names
    CG7108-PA
    DNA polymerase 50K
    DNA polymerase alpha
    DNA polymerase alpha 46,000 gamma subunit
    DNA polymerase alpha 50 kda primase subunit
    DNA polymerase alpha 50,000 gamma subunit
    DNA polymerase alpha 50kD
    DNA polymerase alpha 50kD subunit
    DNA-polymerase alpha
    Prim1-PA
    p50 subunit of DNA polymerase alpha
    NP_523972.2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8340314..8344404
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079248.4 → NP_523972.2  DNA primase subunit 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523972.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24317, Q9VSI0
      Related
      FBpp0076330
      Conserved Domains (1) summary
      cd04860
      Location:41 → 372
      AE_Prim_S; AE_Prim_S: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. Primases are DNA-dependent RNA polymerases which synthesis the short RNA primers required for DNA replication. In addition to its ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24317.2 Q24317

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous