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    Fum3 Fumarase 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39281, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fum3provided by FlyBase
    Official Full Name
    Fumarase 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0036162
    Locus tag
    Dmel_CG6140
    See related
    AllianceGenome:FB:FBgn0036162
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6140; Dmel\CG6140
    Summary
    Predicted to enable fumarate hydratase activity. Predicted to be involved in fumarate metabolic process; malate metabolic process; and tricarboxylic acid cycle. Predicted to be active in mitochondrion. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in fumarase deficiency and lung non-small cell carcinoma. Orthologous to human FH (fumarate hydratase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Fum3 in Genome Data Viewer
    Location:
    68C9-68C9; 3-36 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11463570..11465864, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11456670..11458964, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Vacuolar H[+] ATPase 16kD subunit 3 Neighboring gene antisense RNA:CR46049 Neighboring gene Vacuolar H[+] ATPase 16kD subunit 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A survey of ovary-, testis-, and soma-biased gene expression in Drosophila melanogaster adults. Parisi M, et al. Genome Biol, 2004. PMID 15186491, Free PMC Article
    2. Single-cell transcriptome characteristics of testicular terminal epithelium lineages during aging in the Drosophila. Chen X, et al. Aging Cell, 2024 Mar. PMID 38044573, Free PMC Article
    3. Mechanisms underlying hypoxia tolerance in Drosophila melanogaster: hairy as a metabolic switch. Zhou D, et al. PLoS Genet, 2008 Oct. PMID 18927626, Free PMC Article
    4. Metabolic regulation of proteome stability via N-terminal acetylation controls male germline stem cell differentiation and reproduction. François CM, et al. Nat Commun, 2023 Oct 23. PMID 37872135, Free PMC Article
    5. Quantitative proteomics and phosphoproteomics reveal insights into mechanisms of ocnus function in Drosophila testis development. Zheng Y, et al. BMC Genomics, 2023 May 26. PMID 37237333, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables fumarate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fumarate hydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fumarate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fumarate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in malate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fumarase 3
    Names
    CG6140-PA
    CG6140-PB
    Fum3-PA
    Fum3-PB
    NP_001261710.1
    NP_648467.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11463570..11465864 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274781.1 → NP_001261710.1  fumarase 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261710.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YDH4, Q9VTI5
      Conserved Domains (2) summary
      cd01362
      Location:10 → 466
      Fumarase_classII; Class II fumarases
      PRK00485
      Location:8 → 469
      fumC; fumarate hydratase; Reviewed

    2. NM_140210.2 → NP_648467.1  fumarase 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648467.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YDH4, Q9VTI5
      Related
      FBpp0075907
      Conserved Domains (2) summary
      cd01362
      Location:10 → 466
      Fumarase_classII; Class II fumarases
      PRK00485
      Location:8 → 469
      fumC; fumarate hydratase; Reviewed
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VTI5 Q9VTI5

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