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    SCCRO Squamous cell carcinoma-related oncogene [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39685, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SCCROprovided by FlyBase
    Official Full Name
    Squamous cell carcinoma-related oncogeneprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036510
    Locus tag
    Dmel_CG7427
    See related
    AllianceGenome:FB:FBgn0036510
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7427; Dmel\CG7427; dSCCRO; Sccro
    Summary
    Predicted to enable cullin family protein binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin-like protein binding activity. Involved in cell competition in a multicellular organism and positive regulation of protein neddylation. Located in nucleus. Is expressed in embryonic/larval garland cell and organism. Orthologous to human DCUN1D1 (defective in cullin neddylation 1 domain containing 1) and DCUN1D2 (defective in cullin neddylation 1 domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See SCCRO in Genome Data Viewer
    Location:
    71E1-71E1; 3-43 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15563427..15565559)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15556527..15558659)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Cyclic-AMP response element binding protein A Neighboring gene Argonaute 2 Neighboring gene uncharacterized protein Neighboring gene drop out Neighboring gene UFM1 specific peptidase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Squamous Cell Carcinoma-related Oncogene (SCCRO) Family Members Regulate Cell Growth and Proliferation through Their Cooperative and Antagonistic Effects on Cullin Neddylation. Fu W, et al. J Biol Chem, 2016 Mar 18. PMID 26792857, Free PMC Article
    2. Mechanisms of cell competition emerging from Drosophila studies. Baker NE. Curr Opin Cell Biol, 2017 Oct. PMID 28600967, Free PMC Article
    3. Emerging mechanisms of cell competition. Baker NE. Nat Rev Genet, 2020 Nov. PMID 32778819, Free PMC Article
    4. A set of structural features defines the cis-regulatory modules of antenna-expressed genes in Drosophila melanogaster. López Y, et al. PLoS One, 2014. PMID 25153327, Free PMC Article
    5. Putative synaptic genes defined from a Drosophila whole body developmental transcriptome by a machine learning approach. Pazos Obregón F, et al. BMC Genomics, 2015 Sep 15. PMID 26370122, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-like protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell competition in a multicellular organism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein neddylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein neddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein neddylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    squamous cell carcinoma-related oncogene
    Names
    CG7427-PA
    CG7427-PB
    CG7427-PC
    CG7427-PD
    CG7427-PE
    SCCRO-PA
    SCCRO-PB
    SCCRO-PC
    SCCRO-PD
    SCCRO-PE
    squamous cell carcinoma-related oncogene ortholog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      15563427..15565559
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140520.4 → NP_648777.1  squamous cell carcinoma-related oncogene, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648777.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VUQ8
      UniProtKB/TrEMBL
      D4G7B4, M9PI67
      Related
      FBpp0075314
      Conserved Domains (2) summary
      pfam03556
      Location:132 → 243
      Cullin_binding; Cullin binding
      cl21463
      Location:2 → 49
      UBA_like_SF; UBA domain-like superfamily

    2. NM_001259841.2 → NP_001246770.1  squamous cell carcinoma-related oncogene, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246770.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D4G7B4, M9NDR9
      Conserved Domains (2) summary
      pfam03556
      Location:141 → 252
      Cullin_binding; Cullin binding
      cl21463
      Location:11 → 58
      UBA_like_SF; UBA domain-like superfamily

    3. NM_001259840.2 → NP_001246769.1  squamous cell carcinoma-related oncogene, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246769.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D4G7B4, M9NEA3
      Conserved Domains (2) summary
      pfam03556
      Location:135 → 246
      Cullin_binding; Cullin binding
      cl21463
      Location:5 → 52
      UBA_like_SF; UBA domain-like superfamily

    4. NM_001259842.2 → NP_001246771.1  squamous cell carcinoma-related oncogene, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246771.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D4G7B4, M9NEA3
      Conserved Domains (2) summary
      pfam03556
      Location:135 → 246
      Cullin_binding; Cullin binding
      cl21463
      Location:5 → 52
      UBA_like_SF; UBA domain-like superfamily

    5. NM_001274954.1 → NP_001261883.1  squamous cell carcinoma-related oncogene, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261883.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VUQ8
      UniProtKB/TrEMBL
      D4G7B4, M9PI67
      Conserved Domains (2) summary
      pfam03556
      Location:132 → 243
      Cullin_binding; Cullin binding
      cl21463
      Location:2 → 49
      UBA_like_SF; UBA domain-like superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NDR9 M9NDR9
    M9NEA3 M9NEA3
    M9PI67 M9PI67
    Q9VUQ8.2 Q9VUQ8

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