Diap1 Death-associated inhibitor of apoptosis 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Diap1provided by FlyBase
Official Full Name: Death-associated inhibitor of apoptosis 1provided by FlyBase
Primary source: FLYBASE:FBgn0260635
Locus tag: Dmel_CG12284
See related: AllianceGenome:FB:FBgn0260635
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 0736/01; 1065/03; CG12284; D-iap1; D-IAP1; diap; dIAP; Diap; DIAp; DIAP; diap 1; DIAP I; diap-1; dIAP-1; Diap-1; DIAP-1; Diap-1/Th; diap1; dIap1; dIAP1; DIAP1; diap1/thread; DIAPI; Dmel\CG12284; E(rpr)3-1; E3; Iap; IAP; Iap1; IAP1; l(3)72CDe; l(3)72Dc; l(3)j5C8; l(3)S030605; l(3)S030605b; l(3)S106503; S048915; th; TH; thread; Thread
Summary: Enables several functions, including cysteine-type endopeptidase inhibitor activity involved in apoptotic process; enzyme binding activity; and ubiquitin-like protein ligase activity. Involved in several processes, including germ cell development; protein modification by small protein conjugation; and regulation of signal transduction. Located in nucleus and perinuclear region of cytoplasm. Is expressed in several structures, including Malpighian tubule primordium; ganglia; germline cell; head epidermis primordium; and imaginal disc. Human ortholog(s) of this gene implicated in breast cancer; carcinoma (multiple); and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue. Orthologous to several human genes including BIRC2 (baculoviral IAP repeat containing 2) and BIRC3 (baculoviral IAP repeat containing 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 72D1-72D1; 3-44 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (16038410..16051034, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (16031510..16044134, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

E2F1, DIAP1, and the presence of a homologous chromosome promote while JNK inhibits radiation-induced loss of heterozygosity in Drosophila melanogaster.
Title: E2F1, DIAP1, and the presence of a homologous chromosome promote while JNK inhibits radiation-induced loss of heterozygosity in Drosophila melanogaster.
Expanded polyQ aggregates interact with sarco-endoplasmic reticulum calcium ATPase and Drosophila inhibitor of apoptosis protein1 to regulate polyQ mediated neurodegeneration in Drosophila.
Title: Expanded polyQ aggregates interact with sarco-endoplasmic reticulum calcium ATPase and Drosophila inhibitor of apoptosis protein1 to regulate polyQ mediated neurodegeneration in Drosophila.
Suppression of Patronin deficiency by altered Hippo signaling in Drosophila organ development.
Title: Suppression of Patronin deficiency by altered Hippo signaling in Drosophila organ development.
Syd/JIP3 controls tissue size by regulating Diap1 protein turnover downstream of Yorkie/YAP.
Title: Syd/JIP3 controls tissue size by regulating Diap1 protein turnover downstream of Yorkie/YAP.
dIAP1 and Cyclin A have been identified as two critical genes regulated by JAK/STAT and contributing to the growth of the Hedgehog-expressing cell population in Drosophila wing morphogenesis.
Title: JAK/STAT controls organ size and fate specification by regulating morphogen production and signalling.
Accumulation of Mof at the Diap1 promoter 800 bp upstream of the transcription start site in wild type larvae is significantly higher (up to two folds) compared to mof1 mutants.
Title: Drosophila MOF regulates DIAP1 and induces apoptosis in a JNK dependent pathway.
Both germline and somatic stem cells in the adult Drosophila testis are more resistant to apoptosis-inducing stimuli than their differentiating daughters. Niche signaling causes enhanced expression of DIAP1 in both germline stem cells and somatic cyst stem cells, and the resistance to apoptosis is mediated, at least in part, by this enhanced expression.
Title: Niche signaling promotes stem cell survival in the Drosophila testis via the JAK-STAT target DIAP1.
Ubr3 interacts with DIAP1 and positively regulates DIAP1 activity, possibly by maintaining its active conformation in the apoptosis pathway.
Title: Ubr3 E3 ligase regulates apoptosis by controlling the activity of DIAP1 in Drosophila.
DIAP1 contains distinct instability motifs that regulate inhibitor-of-apoptosis turnover and apoptotic consequences.
Title: Insect inhibitor-of-apoptosis (IAP) proteins are negatively regulated by signal-induced N-terminal degrons absent within viral IAP proteins.
epithelial tube size regulation defines new non-apoptotic roles for Yki, DIAP1 and Ice
Title: Non-canonical roles for Yorkie and Drosophila Inhibitor of Apoptosis 1 in epithelial tube size control.

Submit: New GeneRIF Correction See all GeneRIFs (47)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables NEDD8 ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables caspase binding	IPI Inferred from Physical Interaction more info	PubMed
enables cysteine-type endopeptidase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin conjugating enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-like protein conjugating enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-protein transferase activity	TAS Traceable Author Statement more info	PubMed
enables ubiquitin-specific protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in antennal morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	IPI Inferred from Physical Interaction more info	PubMed
involved_in border follicle cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaeta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of compound eye retinal cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Toll signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein K48-linked ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autoubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein neddylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein polyubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory organ precursor cell division	IGI Inferred from Genetic Interaction more info	PubMed
involved_in spermatid nucleus differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Death-associated inhibitor of apoptosis 1

Names: CG12284-PA; CG12284-PB; CG12284-PC; CG12284-PD; CG12284-PE; CG12284-PF; DIAP1; Diap1-PA; Diap1-PB; Diap1-PC; Diap1-PD; Diap1-PE; Diap1-PF; degradation of inhibitors of apoptosis; drosophila IAP1; drosophila inhibitor of apoptosis; drosophila inhibitor of apoptosis 1; drosophila inhibitor of apoptosis Protein-1; drosophila inhibitor of apoptosis protein; drosophila inhibitor of apoptosis protein 1; drosophila inhibitor-of-apoptosis protein 1; drosophila thread/inhibitor of apoptosis protein-1; inhibitor of apoptosis; inhibitor of apoptosis 1; inhibitor of apoptosis protein 1; inhibitor of apoptosis-1; inhibitor of apoptotic protein 1; inhibitors of apoptosis protein; lethal (3) 72CDe; thread

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

16038410..16051034 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001274989.1 → NP_001261918.1 Death-associated inhibitor of apoptosis 1, isoform F [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V1Z9, A9UN33, Q0E8E4, Q24306, Q8MRM5, Q9VUX5

UniProtKB/TrEMBL

M9PI74

Conserved Domains (2) summary

smart00238
Location:226 → 295

BIR; Baculoviral inhibition of apoptosis protein repeat

pfam13920
Location:387 → 432

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
NM_168644.2 → NP_730097.1 Death-associated inhibitor of apoptosis 1, isoform B [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V1Z9, A9UN33, Q0E8E4, Q24306, Q8MRM5, Q9VUX5

UniProtKB/TrEMBL

M9PI74

Related

FBpp0075254

Conserved Domains (2) summary

smart00238
Location:226 → 295

BIR; Baculoviral inhibition of apoptosis protein repeat

pfam13920
Location:387 → 432

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
NM_079377.3 → NP_524101.2 Death-associated inhibitor of apoptosis 1, isoform A [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V1Z9, A9UN33, Q0E8E4, Q24306, Q8MRM5, Q9VUX5

UniProtKB/TrEMBL

M9PI74

Related

FBpp0075255

Conserved Domains (2) summary

smart00238
Location:226 → 295

BIR; Baculoviral inhibition of apoptosis protein repeat

pfam13920
Location:387 → 432

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
NM_001274988.1 → NP_001261917.1 Death-associated inhibitor of apoptosis 1, isoform E [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V1Z9, A9UN33, Q0E8E4, Q24306, Q8MRM5, Q9VUX5

UniProtKB/TrEMBL

M9PI74

Conserved Domains (2) summary

smart00238
Location:226 → 295

BIR; Baculoviral inhibition of apoptosis protein repeat

pfam13920
Location:387 → 432

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
NM_168645.2 → NP_730098.1 Death-associated inhibitor of apoptosis 1, isoform C [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V1Z9, A9UN33, Q0E8E4, Q24306, Q8MRM5, Q9VUX5

UniProtKB/TrEMBL

M9PI74

Related

FBpp0075256

Conserved Domains (2) summary

smart00238
Location:226 → 295

BIR; Baculoviral inhibition of apoptosis protein repeat

pfam13920
Location:387 → 432

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
NM_001274987.1 → NP_001261916.1 Death-associated inhibitor of apoptosis 1, isoform D [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V1Z9, A9UN33, Q0E8E4, Q24306, Q8MRM5, Q9VUX5

UniProtKB/TrEMBL

M9PI74

Conserved Domains (2) summary

smart00238
Location:226 → 295

BIR; Baculoviral inhibition of apoptosis protein repeat

pfam13920
Location:387 → 432

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)