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    Hsc20 Heat shock protein cognate 20 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 5740624, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Hsc20provided by FlyBase
    Official Full Name
    Heat shock protein cognate 20provided by FlyBase
    Primary source
    FLYBASE:FBgn0263606
    Locus tag
    Dmel_CG34246
    See related
    AllianceGenome:FB:FBgn0263606
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG34246; Dmel\CG34246; l(3)72Do
    Summary
    Predicted to enable ATPase activator activity and protein-folding chaperone binding activity. Involved in iron-sulfur cluster assembly. Is active in mitochondrion. Human ortholog(s) of this gene implicated in sideroblastic anemia. Orthologous to human HSCB (HscB mitochondrial iron-sulfur cluster cochaperone). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Hsc20 in Genome Data Viewer
    Location:
    72D10-72D10; 3-44 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16233127..16234165)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16226227..16227265)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Thioredoxin-related transmembrane protein 3 Neighboring gene Programmed Cell Death 5 Neighboring gene Mediator complex subunit 10 Neighboring gene lethal (3) 72Dp Neighboring gene lethal (3) 72Dr Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Insertion mutants in Drosophila melanogaster Hsc20 halt larval growth and lead to reduced iron-sulfur cluster enzyme activities and impaired iron homeostasis. Uhrigshardt H, et al. J Biol Inorg Chem, 2013 Apr. PMID 23444034, Free PMC Article
    2. Temperature-Related Reaction Norms of Gene Expression: Regulatory Architecture and Functional Implications. Chen J, et al. Mol Biol Evol, 2015 Sep. PMID 25976350, Free PMC Article
    3. Iron absorption in Drosophila melanogaster. Mandilaras K, et al. Nutrients, 2013 May 17. PMID 23686013, Free PMC Article
    4. Hyperactivation of Nrf2 increases stress tolerance at the cost of aging acceleration due to metabolic deregulation. Tsakiri EN, et al. Aging Cell, 2019 Feb. PMID 30537423, Free PMC Article
    5. Two novel DnaJ chaperone proteins CG5001 and P58IPK regulate the pathogenicity of Huntington's disease related aggregates. Deo A, et al. Sci Rep, 2024 Sep 6. PMID 39242711, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein-folding chaperone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in [2Fe-2S] cluster assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in [2Fe-2S] cluster assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in iron-sulfur cluster assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein complex oligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein maturation by iron-sulfur cluster transfer NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    heat shock protein cognate 20
    Names
    CG34246-PA
    Hsc20-PA
    lethal (3) 72Do

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16233127..16234165
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104146.3 → NP_001097616.1  heat shock protein cognate 20 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097616.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNT7
      Conserved Domains (3) summary
      cd06257
      Location:75 → 135
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      PRK03578
      Location:75 → 239
      hscB; co-chaperone HscB; Provisional
      pfam07743
      Location:159 → 231
      HSCB_C; HSCB C-terminal oligomerization domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JNT7 A8JNT7

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