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    nkd naked cuticle [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44843, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nkdprovided by FlyBase
    Official Full Name
    naked cuticleprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002945
    Locus tag
    Dmel_CG11614
    See related
    AllianceGenome:FB:FBgn0002945
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11614; CG18224; Dmel\CG11614; naked; Nkd
    Summary
    Enables PDZ domain binding activity and zinc ion binding activity. Involved in neuroblast fate specification; regulation of canonical Wnt signaling pathway; and segment polarity determination. Located in cytosol and nucleus. Is expressed in several structures, including dorsal epidermis primordium; dorsal-ventral compartment boundary of the wing disc; ectoderm anlage; head epidermis primordium; and imaginal disc. Orthologous to human NKD1 (NKD inhibitor of WNT signaling pathway 1) and NKD2 (NKD inhibitor of WNT signaling pathway 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See nkd in Genome Data Viewer
    Location:
    75F2-75F4; 3-45 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19003741..19045449, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18996841..19038549, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene SET and MYND domain containing, arthropod-specific, member 2 Neighboring gene long non-coding RNA:CR45940 Neighboring gene long non-coding RNA:CR44675 Neighboring gene Accessory gland protein 76A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Zinc-dependent interaction between dishevelled and the Drosophila Wnt antagonist naked cuticle. Rousset R, et al. J Biol Chem, 2002 Dec 13. PMID 12354775
    2. Multiple modes of engrailed regulation in the progression towards cell fate determination. Heemskerk J, et al. Nature, 1991 Aug 1. PMID 1861720, Free PMC Article
    3. Drosophila wingless generates cell type diversity among engrailed expressing cells. Dougan S, et al. Nature, 1992 Nov 26. PMID 1280330
    4. Normal and ectopic domains of the homeotic gene Sex combs reduced of Drosophila. Pelaz S, et al. Development, 1993 Mar. PMID 8100766
    5. Unipolar membrane association of Dishevelled mediates Frizzled planar cell polarity signaling. Axelrod JD. Genes Dev, 2001 May 15. PMID 11358862, Free PMC Article

    See all (195) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Feedback control of Wnt signaling based on ultrastable histidine cluster co-aggregation between Naked/NKD and Axin.
      Title: Feedback control of Wnt signaling based on ultrastable histidine cluster co-aggregation between Naked/NKD and Axin.
    2. Bridging Decapentaplegic and Wingless signaling in Drosophila wings through repression of naked cuticle by Brinker
      Title: Bridging Decapentaplegic and Wingless signaling in Drosophila wings through repression of naked cuticle by Brinker.
    3. Wingless signalling regulates the feedback antagonist naked cuticle through a series of Wingless response elements.
      Title: Regulation of the feedback antagonist naked cuticle by Wingless signaling.
    4. Data show that Drosophila Naked cuticle (Nkd) engages the nuclear import adaptor Importin-alpha3 to antagonize Wnt/beta-catenin signaling.
      Title: Drosophila Naked cuticle (Nkd) engages the nuclear import adaptor Importin-alpha3 to antagonize Wnt/beta-catenin signaling.
    5. Data suggest that Nkd acts at more than one subcellular location within signal-receiving cells to attenuate Wg signaling.
      Title: Cell-autonomous, myristyl-independent activity of the Drosophila Wnt/Wingless antagonist Naked cuticle (Nkd).
    6. Nkd targets Dsh-dependent signal transduction steps in both cytoplasmic and nuclear compartments of cells receiving the Wnt signal.
      Title: An unconventional nuclear localization motif is crucial for function of the Drosophila Wnt/wingless antagonist Naked cuticle.
    7. identification as a zinc-binding metalloprotein and role in antagonizing Wnt signalling via interaction with dishevelled
      Title: Zinc-dependent interaction between dishevelled and the Drosophila Wnt antagonist naked cuticle.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables PDZ domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuroblast fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in segment polarity determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    naked cuticle
    Names
    CG11614-PA
    CG11614-PB
    CG11614-PC
    naked
    nkd-PA
    nkd-PB
    nkd-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19003741..19045449 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275100.1 → NP_001262029.1  naked cuticle, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262029.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCX7

    2. NM_080049.3 → NP_524788.2  naked cuticle, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524788.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95RL6, Q9NIH2, Q9VVV9, Q9VVW0
      Related
      FBpp0074806

    3. NM_001275101.1 → NP_001262030.1  naked cuticle, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262030.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFM6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PCX7 M9PCX7
    M9PFM6 M9PFM6
    Q9VVV9.3 Q9VVV9

    Gene LinkOut

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