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    nkd naked cuticle [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44843, updated on 9-Dec-2024

    Summary

    Official Symbol
    nkdprovided by FlyBase
    Official Full Name
    naked cuticleprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002945
    Locus tag
    Dmel_CG11614
    See related
    AllianceGenome:FB:FBgn0002945
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11614; CG18224; Dmel\CG11614; naked; Nkd
    Summary
    Enables PDZ domain binding activity and zinc ion binding activity. Involved in neuroblast fate specification; regulation of canonical Wnt signaling pathway; and segment polarity determination. Located in cytosol and nucleus. Is expressed in several structures, including dorsal epidermis primordium; dorsal-ventral compartment boundary of the wing disc; ectoderm anlage; head epidermis primordium; and imaginal disc. Orthologous to human NKD1 (NKD inhibitor of WNT signaling pathway 1) and NKD2 (NKD inhibitor of WNT signaling pathway 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See nkd in Genome Data Viewer
    Location:
    75F2-75F4; 3-45 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19003741..19045449, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18996841..19038549, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene SET and MYND domain containing, arthropod-specific, member 2 Neighboring gene long non-coding RNA:CR45940 Neighboring gene long non-coding RNA:CR44675 Neighboring gene Accessory gland protein 76A

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    naked cuticle
    Names
    CG11614-PA
    CG11614-PB
    CG11614-PC
    naked
    nkd-PA
    nkd-PB
    nkd-PC

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19003741..19045449 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275100.1NP_001262029.1  naked cuticle, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262029.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCX7
    2. NM_080049.3NP_524788.2  naked cuticle, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524788.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95RL6, Q9NIH2, Q9VVV9, Q9VVW0
      Related
      FBpp0074806
    3. NM_001275101.1NP_001262030.1  naked cuticle, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262030.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFM6