Ten-m Tenascin major [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ten-mprovided by FlyBase
Official Full Name: Tenascin majorprovided by FlyBase
Primary source: FLYBASE:FBgn0004449
Locus tag: Dmel_CG5723
See related: AllianceGenome:FB:FBgn0004449
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 2017; 5301; BcDNA:AT25108; CG11452; CG5723; CT16449; Dmel\CG5723; l(3)00844; l(3)05301; l(3)05309; l(3)rJ307; l(3)rL201; l(3)rP126; odd(Oz); odz; Odz; odz/ten-m; ten(m); ten-m; Ten-M; ten-m/odz; Ten-mc; Ten79E; ten[m]; Ten[m]
Summary: Enables filamin binding activity; protein heterodimerization activity; and protein homodimerization activity. Involved in several processes, including neuron development; regulation of cell-cell adhesion; and synapse organization. Located in neuromuscular junction; neuronal cell body; and postsynaptic membrane. Is expressed in several structures, including adult sense organ; epithelium; imaginal disc; region of integument; and sensory system neurons. Human ortholog(s) of this gene implicated in cocaine dependence and essential tremor 5. Orthologous to several human genes including TENM1 (teneurin transmembrane protein 1); TENM2 (teneurin transmembrane protein 2); and TENM3 (teneurin transmembrane protein 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 79D4-79E3; 3-47 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (22293044..22407863, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (22286144..22400963, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ten-m/Odz may have had an ancient role in cell-cell communication, parallel to the Notch and wnt pathways. The Ten-m protein binds to the membrane with properties which resemble other membrane-based biochemical oscillators. The oscillatory properties of Ten-m may play a seminal role in arthropod segmentation.
Title: Ancient role of ten-m/odz in segmentation and the transition from sequential to syncytial segmentation.
Ten-m acts in projection neurons autonomously to regulate acetylcholine receptor cluster number and transsynaptically to regulate olfactory receptor neurons active zone number.
Title: Synaptic organization of the Drosophila antennal lobe and its regulation by the Teneurins.
identification of two evolutionarily conserved, epidermal growth factor (EGF)-repeat containing transmembrane Teneurin proteins, Ten-m and Ten-a, as synaptic-partner-matching molecules between projection neuron dendrites and olfactory receptor neuron axons
Title: Teneurins instruct synaptic partner matching in an olfactory map.
study identifies the Teneurins as a key bi-directional trans-synaptic signal involved in general synapse organization, and demonstrates that proteins such as these can also regulate target selection
Title: Trans-synaptic Teneurin signalling in neuromuscular synapse organization and target choice.
Data indicate that during embryonic development, the expression of Filamin and Ten-m partially overlap in ectodermal cells.
Title: Drosophila Ten-m and filamin affect motor neuron growth cone guidance.
the odz gene is required for multiple cell types in the compound retina
Title: Drosophila odz gene is required for multiple cell types in the compound retina.
The structure and membrane orientation of this large enigmatic protein was characterized by raising and employing antibodies directed against discrete Odz polypeptide regions.
Title: The Drosophila odz/ten-m gene encodes a type I, multiply cleaved heterodimeric transmembrane protein.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm2286 (e-PCR)
- UniSTS:51087

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables filamin binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in R7 cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaeta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye corneal lens development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye photoreceptor development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoplasmic microtubule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of alignment of postsynaptic density and presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed
involved_in maintenance of alignment of postsynaptic density and presynaptic active zone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of presynaptic active zone structure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of heterotypic cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynaptic membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynaptic spectrin-associated cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic spectrin-associated cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in presynaptic membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of homotypic cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of homotypic cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of terminal button organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic target attraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic target recognition	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic target recognition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular matrix	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tenascin major

Names: CG5723-PB; CG5723-PD; CG5723-PE; Ten-m-PB; Ten-m-PD; Ten-m-PE; Teneurin-m; odd Oz; odd-Oz; tenascin-like molecule major; tenascin-major; teneurin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

22293044..22407863 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079491.3 → NP_524215.2 tenascin major, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524215.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A8JNW8, O18366, O61307, Q24551, Q9TX59, Q9VNU6

Related

FBpp0078161

Conserved Domains (12) summary

COG3209
Location:1781 → 2454

RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]

cd05819
Location:1218 → 1264

NHL; NHL repeat [structural motif]

TIGR01643
Location:2229 → 2270

YD_repeat_2x; YD repeat (two copies)

TIGR03696
Location:2339 → 2414

Rhs_assc_core; RHS repeat-associated core domain

cd00185
Location:549 → 594

TNFRSF; CRD2 [structural motif]

pfam01500
Location:605 → 773

Keratin_B2; Keratin, high sulfur B2 protein

pfam05593
Location:1617 → 1652

RHS_repeat; RHS Repeat

pfam07974
Location:610 → 637

EGF_2; EGF-like domain

pfam12955
Location:614 → 678

DUF3844; Domain of unknown function (DUF3844)

pfam15636
Location:2627 → 2702

Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

cl18310
Location:1184 → 1499

NHL; NHL repeat unit of beta-propeller proteins

cl22855
Location:512 → 611

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
NM_001275282.1 → NP_001262211.1 tenascin major, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262211.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PGF7

Conserved Domains (12) summary

COG3209
Location:2347 → 3020

RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]

cd05819
Location:1784 → 1830

NHL; NHL repeat [structural motif]

TIGR01643
Location:2795 → 2836

YD_repeat_2x; YD repeat (two copies)

TIGR03696
Location:2905 → 2980

Rhs_assc_core; RHS repeat-associated core domain

cd00185
Location:1106 → 1151

TNFRSF; CRD2 [structural motif]

pfam01500
Location:1162 → 1330

Keratin_B2; Keratin, high sulfur B2 protein

pfam05593
Location:2183 → 2218

RHS_repeat; RHS Repeat

pfam07974
Location:1167 → 1194

EGF_2; EGF-like domain

pfam12955
Location:1171 → 1235

DUF3844; Domain of unknown function (DUF3844)

pfam15636
Location:3193 → 3268

Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

cl18310
Location:1750 → 2065

NHL; NHL repeat unit of beta-propeller proteins

cl22855
Location:1069 → 1198

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
NM_001104191.3 → NP_001097661.2 tenascin major, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097661.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O61307

Conserved Domains (12) summary

COG3209
Location:2347 → 3020

RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]

cd05819
Location:1784 → 1830

NHL; NHL repeat [structural motif]

TIGR01643
Location:2795 → 2836

YD_repeat_2x; YD repeat (two copies)

TIGR03696
Location:2905 → 2980

Rhs_assc_core; RHS repeat-associated core domain

cd00185
Location:1106 → 1151

TNFRSF; CRD2 [structural motif]

pfam01500
Location:1162 → 1330

Keratin_B2; Keratin, high sulfur B2 protein

pfam05593
Location:2183 → 2218

RHS_repeat; RHS Repeat

pfam07974
Location:1167 → 1194

EGF_2; EGF-like domain

pfam12955
Location:1171 → 1235

DUF3844; Domain of unknown function (DUF3844)

pfam15636
Location:3193 → 3268

Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

cl18310
Location:1750 → 2065

NHL; NHL repeat unit of beta-propeller proteins

cl22855
Location:1069 → 1198

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)