Gfat1 Glutamine:fructose-6-phosphate aminotransferase 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Gfat1provided by FlyBase
Official Full Name: Glutamine:fructose-6-phosphate aminotransferase 1provided by FlyBase
Primary source: FLYBASE:FBgn0287209
Locus tag: Dmel_CG12449
See related: AllianceGenome:FB:FBgn0287209
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12449; CG40197; Dmel/Gfat1; Dmel\CG12449; gfat; Gfat; GFAT; gfat1; zep
Summary: Enables glutamine-fructose-6-phosphate transaminase (isomerizing) activity. Involved in UDP-N-acetylglucosamine metabolic process. Located in cytoplasm. Is expressed in several structures, including adult fat body; adult head; embryonic head epidermis; epidermis; and gland. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 12; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including GFPT2 (glutamine-fructose-6-phosphate transaminase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 81F5-81F5; 3-47.1 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (4126442..4137882)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3RHet	NW_001848858.1 (2470208..2481648)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Drosophila GFAT1 and GFAT2 enzymes encode obligate developmental functions.
Title: Drosophila GFAT1 and GFAT2 enzymes encode obligate developmental functions.
By whole-mount in situ hybridization, specific expression of GFAT1 is detected in embryonic chitin-synthesizing tissues and in the corpus cells of salivary glands from late third larval instar.
Title: Functional regulation of glutamine:fructose-6-phosphate aminotransferase 1 (GFAT1) of Drosophila melanogaster in a UDP-N-acetylglucosamine and cAMP-dependent manner.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables carbohydrate derivative binding	IEA Inferred from Electronic Annotation more info
enables glutamine-fructose-6-phosphate transaminase (isomerizing) activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamine-fructose-6-phosphate transaminase (isomerizing) activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamine-fructose-6-phosphate transaminase (isomerizing) activity	IEA Inferred from Electronic Annotation more info
enables glutamine-fructose-6-phosphate transaminase (isomerizing) activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in UDP-N-acetylglucosamine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in UDP-N-acetylglucosamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in carbohydrate derivative biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in fructose 6-phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fructose 6-phosphate metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in protein N-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Glutamine:fructose-6-phosphate aminotransferase 1

Names: CG12449-PA; CG12449-PD; CG12449-PF; CG12449-PH; CG12449-PJ; CG12449-PK; CG12449-PL; CG12449-PM; CG12449-PN; Gfat1-PA; Gfat1-PD; Gfat1-PF; Gfat1-PH; Gfat1-PJ; Gfat1-PK; Gfat1-PL; Gfat1-PM; Gfat1-PN; Glutamine: Fructose-6-Phosphate aminotransferase 1; glucose-fructose amidotransferase 1; zeppelin

NP_001015157.2

EC 2.6.1.16

NP_001015158.1

EC 2.6.1.16

NP_001015159.2

EC 2.6.1.16

NP_001015160.2

EC 2.6.1.16

NP_001015161.2

EC 2.6.1.16

NP_001015162.1

EC 2.6.1.16

NP_001104465.1

EC 2.6.1.16

NP_001188368.1

EC 2.6.1.16

NP_001188369.1

EC 2.6.1.16

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

4126442..4137882

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001201440.1 → NP_001188369.1 Glutamine:fructose-6-phosphate aminotransferase 1, isoform N [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188369.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7PLC7, Q9Y093

Conserved Domains (4) summary

PLN02981
Location:1 → 694

PLN02981; glucosamine:fructose-6-phosphate aminotransferase

cd00714
Location:2 → 297

GFAT; Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In ...

cd05008
Location:381 → 506

SIS_GlmS_GlmD_1; SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal ...

cd05009
Location:539 → 692

SIS_GlmS_GlmD_2; SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal ...
NM_001110995.2 → NP_001104465.1 Glutamine:fructose-6-phosphate aminotransferase 1, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001104465.1

Status: REVIEWED

UniProtKB/TrEMBL

A8Y596, Q9Y093

Conserved Domains (4) summary

PLN02981
Location:1 → 685

PLN02981; glucosamine:fructose-6-phosphate aminotransferase

cd00714
Location:2 → 288

GFAT; Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In ...

cd05008
Location:372 → 497

SIS_GlmS_GlmD_1; SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal ...

cd05009
Location:530 → 683

SIS_GlmS_GlmD_2; SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal ...
NM_001201439.2 → NP_001188368.1 Glutamine:fructose-6-phosphate aminotransferase 1, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188368.1

Status: REVIEWED

UniProtKB/TrEMBL

E8NHS9, Q9Y093

Conserved Domains (4) summary

PLN02981
Location:2 → 643

PLN02981; glucosamine:fructose-6-phosphate aminotransferase

cd00714
Location:1 → 246

GFAT; Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In ...

cd05008
Location:330 → 455

SIS_GlmS_GlmD_1; SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal ...

cd05009
Location:488 → 641

SIS_GlmS_GlmD_2; SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal ...
NM_001015159.4 → NP_001015159.2 Glutamine:fructose-6-phosphate aminotransferase 1, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001015159.2

Status: REVIEWED

UniProtKB/TrEMBL

C3KGM9, Q7PLC5

Conserved Domains (4) summary

COG2222
Location:137 → 493

AgaS; Fructoselysine-6-P-deglycase FrlB and related proteins with duplicated sugar isomerase (SIS) domain [Cell wall/membrane/envelope biogenesis]

cd05008
Location:180 → 305

SIS_GlmS_GlmD_1; SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal ...

cd05009
Location:338 → 491

SIS_GlmS_GlmD_2; SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal ...

cl00319
Location:65 → 96

Gn_AT_II; Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to ...
NM_001015157.4 → NP_001015157.2 Glutamine:fructose-6-phosphate aminotransferase 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001015157.2

Status: REVIEWED

UniProtKB/TrEMBL

Q7PLC7, Q9Y093

Conserved Domains (4) summary

PLN02981
Location:1 → 694

PLN02981; glucosamine:fructose-6-phosphate aminotransferase

cd00714
Location:2 → 297

GFAT; Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In ...

cd05008
Location:381 → 506

SIS_GlmS_GlmD_1; SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal ...

cd05009
Location:539 → 692

SIS_GlmS_GlmD_2; SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal ...
NM_001015160.4 → NP_001015160.2 Glutamine:fructose-6-phosphate aminotransferase 1, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001015160.2

Status: REVIEWED

UniProtKB/TrEMBL

A8Y599, Q9Y093

Conserved Domains (4) summary

PLN02981
Location:1 → 682

PLN02981; glucosamine:fructose-6-phosphate aminotransferase

cd00714
Location:2 → 285

GFAT; Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In ...

cd05008
Location:369 → 494

SIS_GlmS_GlmD_1; SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal ...

cd05009
Location:527 → 680

SIS_GlmS_GlmD_2; SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal ...
NM_001015158.4 → NP_001015158.1 Glutamine:fructose-6-phosphate aminotransferase 1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001015158.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7PLC6, Q9Y093

Conserved Domains (4) summary

PLN02981
Location:1 → 673

PLN02981; glucosamine:fructose-6-phosphate aminotransferase

cd00714
Location:2 → 276

GFAT; Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In ...

cd05008
Location:360 → 485

SIS_GlmS_GlmD_1; SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal ...

cd05009
Location:518 → 671

SIS_GlmS_GlmD_2; SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal ...
NM_001015161.4 → NP_001015161.2 Glutamine:fructose-6-phosphate aminotransferase 1, isoform M [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001015161.2

Status: REVIEWED

UniProtKB/TrEMBL

A8Y5A0, Q9Y093

Conserved Domains (4) summary

PLN02981
Location:1 → 665

PLN02981; glucosamine:fructose-6-phosphate aminotransferase

cd00714
Location:2 → 268

GFAT; Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In ...

cd05008
Location:352 → 477

SIS_GlmS_GlmD_1; SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal ...

cd05009
Location:510 → 663

SIS_GlmS_GlmD_2; SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal ...
NM_001015162.4 → NP_001015162.1 Glutamine:fructose-6-phosphate aminotransferase 1, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001015162.1

Status: REVIEWED

UniProtKB/TrEMBL

A8Y5A1

Conserved Domains (4) summary

COG2222
Location:78 → 434

AgaS; Fructoselysine-6-P-deglycase FrlB and related proteins with duplicated sugar isomerase (SIS) domain [Cell wall/membrane/envelope biogenesis]

cd05008
Location:121 → 246

SIS_GlmS_GlmD_1; SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal ...

cd05009
Location:279 → 432

SIS_GlmS_GlmD_2; SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal ...

cl00319
Location:6 → 37

Gn_AT_II; Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to ...

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A8Y596		A8Y596
A8Y599		A8Y599
A8Y5A0		A8Y5A0
A8Y5A1		A8Y5A1
E8NHS9		E8NHS9
Q7PLC5		Q7PLC5
Q7PLC6		Q7PLC6
Q7PLC7		Q7PLC7
Q9Y093		Q9Y093