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    IQGAP2 IQ motif containing GTPase activating protein 2 [ Gallus gallus (chicken) ]

    Gene ID: 427211, updated on 3-Dec-2024

    Summary

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    Official Symbol
    IQGAP2provided by CGNC
    Official Full Name
    IQ motif containing GTPase activating protein 2provided by CGNC
    Primary source
    CGNC:11128
    See related
    Ensembl:ENSGALG00010010688
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See IQGAP2 in Genome Data Viewer
    Location:
    chromosome: Z
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) Z NC_052572.1 (24003163..24119280, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) Z NC_059536.1 (24003163..24119280, complement)

    Chromosome Z - NC_052572.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121108266 Neighboring gene uncharacterized LOC100857549 Neighboring gene coagulation factor II thrombin receptor Neighboring gene coagulation factor II thrombin receptor like 2 Neighboring gene synaptic vesicle glycoprotein 2C Neighboring gene uncharacterized LOC124417522 Neighboring gene POC5 centriolar protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A comprehensive collection of chicken cDNAs. Boardman PE, et al. Curr Biol, 2002 Nov 19. PMID 12445392
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ras GTPase-activating-like protein IQGAP2
    Names
    IQ motif containing GTPase activating protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277778.1 → NP_001264707.1  ras GTPase-activating-like protein IQGAP2

      Status: PROVISIONAL

      Source sequence(s)
      AC192620, BU324681
      UniProtKB/TrEMBL
      A0A8V0Y613
      Conserved Domains (6) summary
      smart00015
      Location:687 → 707
      IQ; Calmodulin-binding motif
      cd05131
      Location:913 → 1271
      RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
      smart00323
      Location:902 → 1229
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd00014
      Location:42 → 156
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam00612
      Location:719 → 738
      IQ; IQ calmodulin-binding motif
      pfam03836
      Location:1365 → 1493
      RasGAP_C; RasGAP C-terminus

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052572.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      24003163..24119280 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015277326.4 → XP_015132812.1  ras GTPase-activating-like protein IQGAP2 isoform X7

      UniProtKB/TrEMBL
      A0A3Q2UGG0
      Conserved Domains (6) summary
      smart00015
      Location:538 → 558
      IQ; Calmodulin-binding motif
      cd05131
      Location:764 → 1122
      RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
      smart00323
      Location:753 → 1080
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd00014
      Location:42 → 156
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam00612
      Location:570 → 589
      IQ; IQ calmodulin-binding motif
      pfam03836
      Location:1216 → 1348
      RasGAP_C; RasGAP C-terminus

    2. XM_015277323.4 → XP_015132809.1  ras GTPase-activating-like protein IQGAP2 isoform X4

      UniProtKB/TrEMBL
      A0A8V0Y613
      Conserved Domains (6) summary
      smart00015
      Location:688 → 708
      IQ; Calmodulin-binding motif
      cd05131
      Location:914 → 1272
      RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
      smart00323
      Location:903 → 1230
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd00014
      Location:42 → 156
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam00612
      Location:720 → 739
      IQ; IQ calmodulin-binding motif
      pfam03836
      Location:1366 → 1498
      RasGAP_C; RasGAP C-terminus

    3. XM_015277321.4 → XP_015132807.1  ras GTPase-activating-like protein IQGAP2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0Y613
      Related
      ENSGALP00010014395.1, ENSGALT00010025488.1
      Conserved Domains (6) summary
      smart00015
      Location:772 → 792
      IQ; Calmodulin-binding motif
      cd05131
      Location:998 → 1356
      RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
      smart00323
      Location:987 → 1314
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd00014
      Location:42 → 156
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam00612
      Location:804 → 823
      IQ; IQ calmodulin-binding motif
      pfam03836
      Location:1450 → 1582
      RasGAP_C; RasGAP C-terminus

    4. XM_015277325.4 → XP_015132811.1  ras GTPase-activating-like protein IQGAP2 isoform X6

      UniProtKB/TrEMBL
      A0A3Q2UGG0, A0A8V0Y1G1
      Related
      ENSGALP00010014407.1, ENSGALT00010025513.1
      Conserved Domains (6) summary
      smart00015
      Location:539 → 559
      IQ; Calmodulin-binding motif
      cd05131
      Location:765 → 1123
      RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
      smart00323
      Location:754 → 1081
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd00014
      Location:42 → 156
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam00612
      Location:571 → 590
      IQ; IQ calmodulin-binding motif
      pfam03836
      Location:1217 → 1349
      RasGAP_C; RasGAP C-terminus

    5. XM_015277322.4 → XP_015132808.1  ras GTPase-activating-like protein IQGAP2 isoform X3

      UniProtKB/TrEMBL
      A0A8V0Y1E5, A0A8V0Y613
      Related
      ENSGALP00010014391.1, ENSGALT00010025475.1
      Conserved Domains (6) summary
      smart00015
      Location:689 → 709
      IQ; Calmodulin-binding motif
      cd05131
      Location:915 → 1273
      RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
      smart00323
      Location:904 → 1231
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd00014
      Location:42 → 156
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam00612
      Location:721 → 740
      IQ; IQ calmodulin-binding motif
      pfam03836
      Location:1367 → 1499
      RasGAP_C; RasGAP C-terminus

    6. XM_015277324.4 → XP_015132810.1  ras GTPase-activating-like protein IQGAP2 isoform X5

      UniProtKB/TrEMBL
      A0A3Q2UGG0
      Related
      ENSGALP00010014402.1, ENSGALT00010025501.1
      Conserved Domains (6) summary
      smart00015
      Location:623 → 643
      IQ; Calmodulin-binding motif
      cd05131
      Location:849 → 1207
      RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
      smart00323
      Location:838 → 1165
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd00014
      Location:42 → 156
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam00612
      Location:655 → 674
      IQ; IQ calmodulin-binding motif
      pfam03836
      Location:1301 → 1433
      RasGAP_C; RasGAP C-terminus

    7. XM_015277320.4 → XP_015132806.1  ras GTPase-activating-like protein IQGAP2 isoform X1

      UniProtKB/TrEMBL
      A0A8V0Y613, A0A8V0Y7K9
      Related
      ENSGALP00010014388.1, ENSGALT00010025469.1
      Conserved Domains (6) summary
      smart00015
      Location:773 → 793
      IQ; Calmodulin-binding motif
      cd05131
      Location:999 → 1357
      RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
      smart00323
      Location:988 → 1315
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd00014
      Location:42 → 156
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam00612
      Location:805 → 824
      IQ; IQ calmodulin-binding motif
      pfam03836
      Location:1451 → 1583
      RasGAP_C; RasGAP C-terminus

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_059536.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      24003163..24119280 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046935050.1 → XP_046791006.1  ras GTPase-activating-like protein IQGAP2 isoform X7

      UniProtKB/TrEMBL
      A0A3Q2UGG0

    2. XM_046935047.1 → XP_046791003.1  ras GTPase-activating-like protein IQGAP2 isoform X4

      UniProtKB/TrEMBL
      A0A8V0Y613

    3. XM_046935045.1 → XP_046791001.1  ras GTPase-activating-like protein IQGAP2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0Y613

    4. XM_046935049.1 → XP_046791005.1  ras GTPase-activating-like protein IQGAP2 isoform X6

      UniProtKB/TrEMBL
      A0A3Q2UGG0, A0A8V0Y1G1

    5. XM_046935046.1 → XP_046791002.1  ras GTPase-activating-like protein IQGAP2 isoform X3

      UniProtKB/TrEMBL
      A0A8V0Y1E5, A0A8V0Y613

    6. XM_046935048.1 → XP_046791004.1  ras GTPase-activating-like protein IQGAP2 isoform X5

      UniProtKB/TrEMBL
      A0A3Q2UGG0

    7. XM_046935044.1 → XP_046791000.1  ras GTPase-activating-like protein IQGAP2 isoform X1

      UniProtKB/TrEMBL
      A0A8V0Y613, A0A8V0Y7K9
    Nucleotide Protein Strain
    Heading Accession and Version

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