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    Tmem266 transmembrane protein 266 [ Mus musculus (house mouse) ]

    Gene ID: 244886, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tmem266provided by MGI
    Official Full Name
    transmembrane protein 266provided by MGI
    Primary source
    MGI:MGI:2142980
    See related
    Ensembl:ENSMUSG00000032313 AllianceGenome:MGI:2142980
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HVRP1; 9630029F15
    Summary
    Predicted to enable protein homodimerization activity. Predicted to be involved in monoatomic ion transport and transmembrane transport. Predicted to be located in cytosol. Predicted to be active in dendrite and plasma membrane. Orthologous to human TMEM266 (transmembrane protein 266). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 10.2), ovary adult (RPKM 2.6) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem266 in Genome Data Viewer
    Location:
    9 B; 9 29.98 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (55234194..55345629)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (55326913..55438345)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene F-box protein 22 Neighboring gene neuregulin 4 Neighboring gene serpine1 mRNA binding protein 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9762 Neighboring gene STARR-seq mESC enhancer starr_24189 Neighboring gene VISTA enhancer mm1754 Neighboring gene STARR-seq mESC enhancer starr_24190 Neighboring gene electron transferring flavoprotein, alpha polypeptide Neighboring gene STARR-positive B cell enhancer ABC_E11406 Neighboring gene STARR-seq mESC enhancer starr_24191 Neighboring gene predicted gene 5917

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Insight into the function of a unique voltage-sensor protein (TMEM266) and its short form in mouse cerebellum. Kawai T, et al. Biochem J, 2022 Jun 17. PMID 35574701
    2. Evidence for functional diversity between the voltage-gated proton channel Hv1 and its closest related protein HVRP1. Kim IH, et al. PLoS One, 2014. PMID 25165868, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT enables voltage-gated channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 266
    Names
    Hv1 related protein 1
    transmembrane protein C15orf27 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357568.2 → NP_001344497.1  transmembrane protein 266 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      CT025532
      Conserved Domains (1) summary
      pfam00520
      Location:1 → 93
      Ion_trans; Ion transport protein

    2. NM_001421582.1 → NP_001408511.1  transmembrane protein 266 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT025532

    3. NM_172923.5 → NP_766511.1  transmembrane protein 266 isoform 1

      See identical proteins and their annotated locations for NP_766511.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      CT025532
      Consensus CDS
      CCDS23203.1
      UniProtKB/Swiss-Prot
      B1B1B3, Q6NVG3, Q8BZB3
      Related
      ENSMUSP00000034862.5, ENSMUST00000034862.5
      Conserved Domains (1) summary
      pfam00520
      Location:133 → 218
      Ion_trans; Ion transport protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      55234194..55345629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155007.1 → XP_036010900.1  transmembrane protein 266 isoform X3

    2. XM_030244382.2 → XP_030100242.1  transmembrane protein 266 isoform X3

    3. XM_036155005.1 → XP_036010898.1  transmembrane protein 266 isoform X1

      Conserved Domains (1) summary
      pfam00520
      Location:35 → 153
      Ion_trans; Ion transport protein

    4. XM_030244380.2 → XP_030100240.1  transmembrane protein 266 isoform X1

      Conserved Domains (1) summary
      pfam00520
      Location:35 → 153
      Ion_trans; Ion transport protein

    5. XM_036155006.1 → XP_036010899.1  transmembrane protein 266 isoform X3

    6. XM_006511161.4 → XP_006511224.1  transmembrane protein 266 isoform X1

      See identical proteins and their annotated locations for XP_006511224.1

      Conserved Domains (1) summary
      pfam00520
      Location:35 → 153
      Ion_trans; Ion transport protein

    7. XM_030244379.2 → XP_030100239.1  transmembrane protein 266 isoform X1

      Conserved Domains (1) summary
      pfam00520
      Location:35 → 153
      Ion_trans; Ion transport protein

    8. XM_006511164.1 → XP_006511227.1  transmembrane protein 266 isoform X2

      See identical proteins and their annotated locations for XP_006511227.1

      Conserved Domains (1) summary
      pfam00520
      Location:1 → 93
      Ion_trans; Ion transport protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BZB3.3 GenPept UniProtKB/Swiss-Prot:Q8BZB3

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