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    LAT2 linker for activation of T cells family member 2 [ Gallus gallus (chicken) ]

    Gene ID: 417489, updated on 3-Dec-2024

    Summary

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    Symbol
    LAT2provided by CGNC
    Full Name
    linker for activation of T cells family member 2provided by CGNC
    Primary source
    CGNC:890
    See related
    Ensembl:ENSGALG00010029420
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    WBSCR5
    Orthologs
    human mouse all
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    Genomic context

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    See LAT2 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 19 NC_052550.1 (3344682..3360721, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 19 NC_052591.1 (3073431..3089483, complement)

    Chromosome 19 - NC_052550.1Genomic Context describing neighboring genes Neighboring gene CAP-GLY domain containing linker protein 2 Neighboring gene uncharacterized LOC101747302 Neighboring gene replication factor C subunit 2 Neighboring gene eukaryotic translation initiation factor 4H Neighboring gene uncharacterized LOC107054785 Neighboring gene MYB binding protein 1a Neighboring gene microRNA 7444 Neighboring gene spinster homolog 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Grb2 and the non-T cell activation linker NTAL constitute a Ca(2+)-regulating signal circuit in B lymphocytes. Stork B, et al. Immunity, 2004 Nov. PMID 15539154
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in B cell activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in B cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    linker for activation of T-cells family member 2
    Names
    Williams-Beuren syndrome chromosome region 5 homolog
    linker for activation of B-cells
    non-T cell activation linker

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007482.2 → NP_001007483.2  linker for activation of T-cells family member 2

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000323
      UniProtKB/Swiss-Prot
      Q5S7W5
      Related
      ENSGALP00010043861.1, ENSGALT00010071170.1

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052550.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      3344682..3360721 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046902322.1 → XP_046758278.1  linker for activation of T-cells family member 2 isoform X4

      UniProtKB/Swiss-Prot
      Q5S7W5

    2. XM_046902319.1 → XP_046758275.1  linker for activation of T-cells family member 2 isoform X2

      UniProtKB/TrEMBL
      A0A8V1AI89, A0A8V1ANP3

    3. XM_046902321.1 → XP_046758277.1  linker for activation of T-cells family member 2 isoform X3

      UniProtKB/TrEMBL
      A0A8V1AM55

    4. XM_040650046.2 → XP_040505980.1  linker for activation of T-cells family member 2 isoform X3

      UniProtKB/TrEMBL
      A0A8V1AM55

    5. XM_046902320.1 → XP_046758276.1  linker for activation of T-cells family member 2 isoform X3

      UniProtKB/TrEMBL
      A0A8V1AM55
      Related
      ENSGALP00010043862.1, ENSGALT00010071171.1

    6. XM_046902318.1 → XP_046758274.1  linker for activation of T-cells family member 2 isoform X2

      UniProtKB/TrEMBL
      A0A8V1AI89, A0A8V1ANP3

    7. XM_046902317.1 → XP_046758273.1  linker for activation of T-cells family member 2 isoform X2

      UniProtKB/TrEMBL
      A0A8V1AI89, A0A8V1ANP3
      Related
      ENSGALP00010043860.1, ENSGALT00010071169.1

    8. XM_004950518.5 → XP_004950575.3  linker for activation of T-cells family member 2 isoform X1

      UniProtKB/Swiss-Prot
      Q5S7W5
      UniProtKB/TrEMBL
      A0A8V1ACX2

    9. XM_040650045.2 → XP_040505979.1  linker for activation of T-cells family member 2 isoform X1

      UniProtKB/Swiss-Prot
      Q5S7W5
      UniProtKB/TrEMBL
      A0A8V1ACX2

    10. XM_004950516.5 → XP_004950573.3  linker for activation of T-cells family member 2 isoform X1

      UniProtKB/Swiss-Prot
      Q5S7W5
      UniProtKB/TrEMBL
      A0A8V1ACX2
      Related
      ENSGALP00010043859.1, ENSGALT00010071168.1

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052591.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      3073431..3089483 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046929988.1 → XP_046785944.1  linker for activation of T-cells family member 2 isoform X4

      UniProtKB/Swiss-Prot
      Q5S7W5

    2. XM_046929984.1 → XP_046785940.1  linker for activation of T-cells family member 2 isoform X2

      UniProtKB/TrEMBL
      A0A8V1AI89

    3. XM_046929987.1 → XP_046785943.1  linker for activation of T-cells family member 2 isoform X3

      UniProtKB/TrEMBL
      A0A8V1AM55

    4. XM_046929985.1 → XP_046785941.1  linker for activation of T-cells family member 2 isoform X3

      UniProtKB/TrEMBL
      A0A8V1AM55

    5. XM_046929986.1 → XP_046785942.1  linker for activation of T-cells family member 2 isoform X3

      UniProtKB/TrEMBL
      A0A8V1AM55

    6. XM_046929983.1 → XP_046785939.1  linker for activation of T-cells family member 2 isoform X2

      UniProtKB/TrEMBL
      A0A8V1AI89

    7. XM_046929982.1 → XP_046785938.1  linker for activation of T-cells family member 2 isoform X2

      UniProtKB/TrEMBL
      A0A8V1AI89

    8. XM_046929981.1 → XP_046785937.1  linker for activation of T-cells family member 2 isoform X1

      UniProtKB/Swiss-Prot
      Q5S7W5

    9. XM_046929979.1 → XP_046785935.1  linker for activation of T-cells family member 2 isoform X1

      UniProtKB/Swiss-Prot
      Q5S7W5

    10. XM_046929980.1 → XP_046785936.1  linker for activation of T-cells family member 2 isoform X1

      UniProtKB/Swiss-Prot
      Q5S7W5
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5S7W5.1 GenPept UniProtKB/Swiss-Prot:Q5S7W5

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