PPIF peptidylprolyl isomerase F [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: PPIFprovided by VGNC
Official Full Name: peptidylprolyl isomerase Fprovided by VGNC
Primary source: VGNC:VGNC:33198
See related: BGD:BT18073; Ensembl:ENSBTAG00000016711
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: CypD; CyP-D
Annotation information: Note: This gene encodes a 179 aa mature peptide that is found in the mitochondrion. It has been labeled 'cyclophilin D'. This same name has also been applied to a different cytoplasmic protein of 370 aa, which is represented by GeneID 281420, PPID. [12 Mar 2012]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 28

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	28	NC_037355.1 (34966705..34973641)

Chromosome 28 - NC_037355.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037355.1 Chromosome 28 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LKT-mediated cell death involve dynamin-2 and cyclophilin D.
Title: Dynamin-2-dependent targeting of mannheimia haemolytica leukotoxin to mitochondrial cyclophilin D in bovine lymphoblastoid cells.
Mannheimia haemolytica leukotoxin binds cyclophilin D on bovine neutrophil mitochondria.
Title: Mannheimia haemolytica leukotoxin binds cyclophilin D on bovine neutrophil mitochondria.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables peptidyl-prolyl cis-trans isomerase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to hydrogen peroxide	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein folding	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein peptidyl-prolyl isomerization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of mitochondrial membrane permeability involved in programmed necrotic cell death	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: peptidyl-prolyl cis-trans isomerase F, mitochondrial

Names: PPIase F; cyclophilin D; cyclophilin F; peptidyl-prolyl cis-trans isomerase, mitochondrial; rotamase F

NP_001001597.2

EC 5.2.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001597.2 → NP_001001597.2 peptidyl-prolyl cis-trans isomerase F, mitochondrial precursor

Status: VALIDATED

Source sequence(s)

NKLS02000028

Related

ENSBTAP00070032250.1, ENSBTAT00070053709.1