U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    Zbtb24 zinc finger and BTB domain containing 24 [ Mus musculus (house mouse) ]

    Gene ID: 268294, updated on 9-Dec-2024

    Summary

    Official Symbol
    Zbtb24provided by MGI
    Official Full Name
    zinc finger and BTB domain containing 24provided by MGI
    Primary source
    MGI:MGI:3039618
    See related
    Ensembl:ENSMUSG00000019826 AllianceGenome:MGI:3039618
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bif1; Bsg1; ZNF450
    Summary
    This gene encodes a protein containing eight C2H2-type zinc fingers and a BTB domain. Expression of this gene is induced by bone morphogenetic protein-2 signaling. Mutation of the related gene in humans causes immunodeficiency-centromeric instability-facial anomalies syndrome-2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
    Expression
    Ubiquitous expression in thymus adult (RPKM 6.0), ovary adult (RPKM 5.3) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Zbtb24 in Genome Data Viewer
    Location:
    10 B1; 10 22.38 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (41326354..41341578)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (41450358..41465582)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene adenylate kinase 9 Neighboring gene STARR-seq mESC enhancer starr_26448 Neighboring gene predicted gene, 25626 Neighboring gene STARR-seq mESC enhancer starr_26449 Neighboring gene STARR-seq mESC enhancer starr_26450 Neighboring gene STARR-positive B cell enhancer ABC_E2321 Neighboring gene predicted gene, 53622 Neighboring gene STARR-seq mESC enhancer starr_26452 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:41197812-41197921 Neighboring gene predicted gene, 51797 Neighboring gene microtubule associated monooxygenase, calponin and LIM domain containing 1 Neighboring gene sphingomyelin phosphodiesterase 2, neutral

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    zinc finger and BTB domain-containing protein 24
    Names
    BMP-induced factor 1
    bone morphogenetic protein-induced factor 1
    brain specific protein 1
    zinc finger protein 450

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277229.1NP_001264158.1  zinc finger and BTB domain-containing protein 24 isoform 2

      See identical proteins and their annotated locations for NP_001264158.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the coding region and lacks an exon, which results in a segment containing a frameshift, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC153360, BC050933
      Consensus CDS
      CCDS87996.1
      UniProtKB/Swiss-Prot
      Q80X44
      Related
      ENSMUSP00000148861.2, ENSMUST00000213797.2
      Conserved Domains (6) summary
      smart00225
      Location:38133
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5048
      Location:328490
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:295315
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:294315
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:27128
      BTB; BTB/POZ domain
      pfam13465
      Location:308332
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001277230.1NP_001264159.1  zinc finger and BTB domain-containing protein 24 isoform 3

      See identical proteins and their annotated locations for NP_001264159.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks several 3' coding exons and its transcription extends past a splice site used in variant 1, resulting in a distinct 3' coding region and 3' UTR. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC153360, AK042114, AK169260
      Consensus CDS
      CCDS87997.1
      UniProtKB/Swiss-Prot
      Q80X44
      Related
      ENSMUSP00000150197.2, ENSMUST00000216656.2
      Conserved Domains (4) summary
      smart00225
      Location:38133
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:295315
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:294315
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:27128
      BTB; BTB/POZ domain
    3. NM_153398.3NP_700447.2  zinc finger and BTB domain-containing protein 24 isoform 1

      See identical proteins and their annotated locations for NP_700447.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC153360, BC050933
      Consensus CDS
      CCDS23804.1
      UniProtKB/Swiss-Prot
      Q3UIB7, Q7TPC4, Q80X44, Q8CJC9
      Related
      ENSMUSP00000079592.9, ENSMUST00000080771.10
      Conserved Domains (5) summary
      smart00225
      Location:38133
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5048
      Location:320479
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:407427
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:27128
      BTB; BTB/POZ domain
      pfam13465
      Location:420443
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_102360.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the start codon used in variant 1 renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC153360, BC050933

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      41326354..41341578
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512748.4XP_006512811.1  zinc finger and BTB domain-containing protein 24 isoform X1

      Conserved Domains (3) summary
      COG5048
      Location:320455
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:295315
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18212
      Location:14131
      BTB_POZ_ZBTB24_ZNF450; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24)

    RNA

    1. XR_004936187.1 RNA Sequence