Sync syncoilin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Syncprovided by MGI
Official Full Name: syncoilinprovided by MGI
Primary source: MGI:MGI:1916078
See related: Ensembl:ENSMUSG00000001333 AllianceGenome:MGI:1916078
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SNIP4; 1110057H03Rik
Summary: Acts upstream of or within intermediate filament-based process. Located in several cellular components, including Z disc; neuromuscular junction; and sarcolemma. Is expressed in tibialis anterior. Orthologous to human SYNC (syncoilin, intermediate filament protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in heart adult (RPKM 5.1), limb E14.5 (RPKM 2.2) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.2; 4 63.26 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (129181066..129203175)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (129287256..129309383)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Single-cell brain atlas of Parkinson's disease mouse model.
Title: Single-cell brain atlas of Parkinson's disease mouse model.
in the liver, syncoilin is predominantly expressed by activated Hepatic stellate cells and displays very low-expression levels in other liver cell types, making it a good marker of activated Hepatic stellate cells.
Title: Syncoilin is an intermediate filament protein in activated hepatic stellate cells.
A neuronal analysis of the syncoilin-null mouse (Sync(-/-)) revealed a reduced ability in accelerating treadmill and rotarod tests.
Title: Syncoilin modulates peripherin filament networks and is necessary for large-calibre motor neurons.
Despite lacking an apparent structural role in striated muscle, the three syncoilin isoforms are differentially and strongly upregulated during muscle regeneration and atrophy in C57BL/6 mice, possibly suggesting an atypical role for syncoilin in muscle.
Title: Syncoilin isoform organization and differential expression in murine striated muscle.
A second viable syncoilin knockout model and highlights the importance of further investigations to determine the role of syncoilin in skeletal muscle.
Title: Analysis of skeletal muscle function in the C57BL6/SV129 syncoilin knockout mouse.
Syncoilin may play a supportive role for desmin in the efficient coupling of mechanical stress between the myofibril and muscle fiber exterior.
Title: Syncoilin is required for generating maximum isometric stress in skeletal muscle but dispensable for muscle cytoarchitecture.
The data show that absence of alpha-dystrobrevin or desmin leads to dynamic changes in syncoilin that may compensate for, or participate in, different muscle myopathies.
Title: Intermediate filament-like protein syncoilin in normal and myopathic striated muscle.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:489239

Sync (e-PCR), detects polymorphism
- UniSTS:224164

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in intermediate filament-based process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intermediate filament-based process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in Z disc	IBA Inferred from Biological aspect of Ancestor more info
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in intermediate filament	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in neuromuscular junction	IBA Inferred from Biological aspect of Ancestor more info
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in sarcolemma	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: syncoilin

Names: syncoilin intermediate filament 1; syncoilin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.