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    sult2st1 sulfotransferase family 2, cytosolic sulfotransferase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 338214, updated on 2-Nov-2024

    Summary

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    Official Symbol
    sult2st1provided by ZNC
    Official Full Name
    sulfotransferase family 2, cytosolic sulfotransferase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030219-114
    See related
    Ensembl:ENSDARG00000033170 AllianceGenome:ZFIN:ZDB-GENE-030219-114
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sult2st; id:ibd1140
    Summary
    Enables sulfotransferase activity and sulfurtransferase activity. Predicted to be involved in sulfation. Predicted to be active in cytoplasm. Is expressed in blood; cardiovascular system; digestive system; and yolk syncytial layer. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 14 and prostate cancer. Orthologous to several human genes including SULT2B1 (sulfotransferase family 2B member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See sult2st1 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (630290..645972, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (624354..640031, complement)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene brain specific kinase 146 Neighboring gene wu:fj29h11 Neighboring gene sulfotransferase family 2, cytosolic sulfotransferase 2 Neighboring gene Ras association and DIL domains 2b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Sulphonation of dehydroepiandrosterone and neurosteroids: molecular cloning, expression, and functional characterization of a novel zebrafish SULT2 cytosolic sulphotransferase. Sugahara T, et al. Biochem J, 2003 Nov 1. PMID 12885295, Free PMC Article
    2. Characterization of a zebrafish estrogen-sulfating cytosolic sulfotransferase: inhibitory effects and mechanism of action of phytoestrogens. Ohkimoto K, et al. Chem Biol Interact, 2004 Jan 15. PMID 14726148
    3. Identification of novel hydroxysteroid-sulfating cytosolic SULTs, SULT2 ST2 and SULT2 ST3, from zebrafish: cloning, expression, characterization, and developmental expression. Yasuda S, et al. Arch Biochem Biophys, 2006 Nov 1. PMID 17045951
    4. Embryonic atrazine exposure and later in life behavioral and brain transcriptomic, epigenetic, and pathological alterations in adult male zebrafish. Horzmann KA, et al. Cell Biol Toxicol, 2021 Jun. PMID 32737625, Free PMC Article
    5. Identification and characterization of 5α-cyprinol-sulfating cytosolic sulfotransferases (Sults) in the zebrafish (Danio rerio). Kurogi K, et al. J Steroid Biochem Mol Biol, 2017 Nov. PMID 28807679, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This protein was isolated, characterized and examined for enzymatic activities using a variety of endogenous compounds as substrates.
      Title: Characterization of a zebrafish estrogen-sulfating cytosolic sulfotransferase: inhibitory effects and mechanism of action of phytoestrogens.
    2. SULT2 ST2 and SULT2 ST3 showed distinct patterns of expression during embryonic development and throughout the larval stage onto maturity.
      Title: Identification of novel hydroxysteroid-sulfating cytosolic SULTs, SULT2 ST2 and SULT2 ST3, from zebrafish: cloning, expression, characterization, and developmental expression.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfurtransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in sulfation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sulfotransferase family 2, cytosolic sulfotransferase 1
    Names
    sulfotransferase family, cytosolic sulfotransferase 2
    NP_944596.2
    XP_005156055.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198914.2 → NP_944596.2  sulfotransferase family 2, cytosolic sulfotransferase 1

      See identical proteins and their annotated locations for NP_944596.2

      Status: PROVISIONAL

      Source sequence(s)
      BC064294
      UniProtKB/TrEMBL
      Q6P2U4
      Related
      ENSDARP00000048631.5, ENSDART00000048632.8
      Conserved Domains (1) summary
      pfam00685
      Location:35 → 279
      Sulfotransfer_1; Sulfotransferase domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      630290..645972 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005155998.4 → XP_005156055.1  sulfotransferase family 2, cytosolic sulfotransferase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B2C8, E7F734
      Related
      ENSDARP00000097437.3, ENSDART00000106659.5
      Conserved Domains (1) summary
      pfam00685
      Location:35 → 279
      Sulfotransfer_1; Sulfotransferase domain
    Nucleotide Protein Strain
    Heading Accession and Version

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