TEC tec protein tyrosine kinase [Homo sapiens (human)] - Gene

Summary

Official Symbol: TECprovided by HGNC
Official Full Name: tec protein tyrosine kinaseprovided by HGNC
Primary source: HGNC:HGNC:11719
See related: Ensembl:ENSG00000135605 MIM:600583; AllianceGenome:HGNC:11719
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PSCTK4
Summary: The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in bone marrow (RPKM 2.4), esophagus (RPKM 1.4) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 4p12-p11

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (48135783..48269838, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (48102615..48236780, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (48137800..48271855, complement)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TEC kinase stabilizes PLK4 to promote liver cancer metastasis.
Title: TEC kinase stabilizes PLK4 to promote liver cancer metastasis.
Tec may mediate the production and release of pro-inflammatory cytokine IL-8 from human alveolar epithelial cells A549 induced by LPS via the p38 MAPK and ERK MAPK signal pathways.
Title: [Role and mechanism of nonreceptor tyrosine kinase Tec in endotoxin/lipopolysaccharide-induced interleukin-8 production in human alveolar epithelial cells A549].
TEC is yet another regulator of FGF2-mediated Human pluripotent stem cells pluripotency and differentiation.
Title: Tyrosine Kinase Expressed in Hepatocellular Carcinoma, TEC, Controls Pluripotency and Early Cell Fate Decisions of Human Pluripotent Stem Cells via Regulation of Fibroblast Growth Factor-2 Secretion.
High TEC expression is associated with the development of Mallory Denk Bodies in balloon cells in alcoholic hepatitis.
Title: The role of Tec kinase signaling pathways in the development of Mallory Denk Bodies in balloon cells in alcoholic hepatitis.
using RNA interference, the identified compounds corroborate the role of Tec kinase in unconventional secretion of FGF2.
Title: Small Molecule Inhibitors Targeting Tec Kinase Block Unconventional Secretion of Fibroblast Growth Factor 2.
These results provide the first evidence that Nef interacts with cytoplasmic tyrosine kinases of the Tec family and suggest that Nef provides a mechanistic link between HIV-1 and Itk signaling in the viral life cycle.
Title: The accessory factor Nef links HIV-1 to Tec/Btk kinases in an Src homology 3 domain-dependent manner.
results suggest that the oncogenic effect of the t(3;9) translocation may be due to the TFG-TEC chimeric protein and that fusion of the TFG (NTD) to the TEC protein produces a gain-of-function chimeric product
Title: The TFG-TEC fusion gene created by the t(3;9) translocation in human extraskeletal myxoid chondrosarcomas encodes a more potent transcriptional activator than TEC.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Overexpression of Tec is associated with the tumorigenesis and development of liver cancer.
Title: [The expression of Tec and the level of its phosphorylation in primary hepatic carcinomas].
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetics of rheumatoid arthritis contributes to biology and drug discovery. EBI GWAS Catalog EBI GWAS CatalogPubMed
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Nef	nef	A cell-based bimolecular fluorescence complementation assay demonstrates that HIV-1 Nef interacts with the Tec family members Bmx, Btk, and Itk but not Tec or Txk. Mutation A96I in the Tec SH3 domain dramatically enhances interaction with Nef	PubMed
Pr55(Gag)	gag	Tec kinase chemical inhibitors diminish the recruitment of ITK to the plasma membrane perturbing HIV-1 Gag-ITK co-localization, disrupting F-actin polymerization, and inhibiting HIV-1 release and replication	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-111508 (e-PCR)
- UniSTS:183828

D4S518 (e-PCR)
- UniSTS:47389

SHGC-86308 (e-PCR)
- UniSTS:104515

RH70608 (e-PCR)
- UniSTS:74593

RW11 (e-PCR)
- UniSTS:241559

D4S3131 (e-PCR)
- UniSTS:32948

D4S2738 (e-PCR)
- UniSTS:29389

SHGC-51527 (e-PCR)
- UniSTS:47846

G34338 (e-PCR)
- UniSTS:74750

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipid binding	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in B cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in T cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adaptive immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in integrin-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of platelet activation	IDA Inferred from Direct Assay more info	PubMed
involved_in tissue regeneration	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: tyrosine-protein kinase Tec

NP_003206.2

EC 2.7.10.2

XP_011512039.1

EC 2.7.10.2

XP_011512043.2

EC 2.7.10.2

XP_047272062.1

EC 2.7.10.2

XP_047272063.1

EC 2.7.10.2

XP_047272064.1

EC 2.7.10.2

XP_054206738.1

EC 2.7.10.2

XP_054206739.1

EC 2.7.10.2

XP_054206740.1

EC 2.7.10.2

XP_054206741.1

EC 2.7.10.2

XP_054206742.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003215.3 → NP_003206.2 tyrosine-protein kinase Tec

See identical proteins and their annotated locations for NP_003206.2

Status: REVIEWED

Source sequence(s)

AC079118, AC098873, BC101713

Consensus CDS

CCDS3481.1

UniProtKB/Swiss-Prot

B7ZKZ6, P42680, Q3MIS5

Related

ENSP00000370912.3, ENST00000381501.8

Conserved Domains (4) summary

cd10396
Location:240 → 346

SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)

cd11905
Location:182 → 237

SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)

cd01238
Location:7 → 148

PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain

cd05114
Location:365 → 624

PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000004.12 Reference GRCh38.p14 Primary Assembly

Range

48135783..48269838 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047416106.1 → XP_047272062.1 tyrosine-protein kinase Tec isoform X1
XM_011513737.3 → XP_011512039.1 tyrosine-protein kinase Tec isoform X2

See identical proteins and their annotated locations for XP_011512039.1

Conserved Domains (5) summary

cd10396
Location:204 → 310

SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)

cd11905
Location:146 → 201

SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)

cd05114
Location:329 → 588

PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase

pfam07714
Location:334 → 583

Pkinase_Tyr; Protein tyrosine kinase

cl17171
Location:11 → 112

PH-like; Pleckstrin homology-like domain
XM_047416107.1 → XP_047272063.1 tyrosine-protein kinase Tec isoform X4
XM_011513741.2 → XP_011512043.2 tyrosine-protein kinase Tec isoform X3
XM_047416108.1 → XP_047272064.1 tyrosine-protein kinase Tec isoform X5