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    Paics phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 140946, updated on 9-Dec-2024

    Summary

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    Symbol
    Paicsprovided by RGD
    Full Name
    phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthaseprovided by RGD
    Primary source
    RGD:620066
    See related
    EnsemblRapid:ENSRNOG00000002101 AllianceGenome:RGD:620066
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Airc; Ade2h1
    Summary
    Predicted to enable identical protein binding activity; phosphoribosylaminoimidazole carboxylase activity; and phosphoribosylaminoimidazolesuccinocarboxamide synthase activity. Involved in G1/S transition of mitotic cell cycle. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human PAICS (phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 540.1), Adrenal (RPKM 531.0) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Paics in Genome Data Viewer
    Location:
    14p11
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (31553355..31586843, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (31199086..31232731, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (33563884..33580944, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096735 Neighboring gene uncharacterized LOC120096737 Neighboring gene ARF like GTPase 9 Neighboring gene signal recognition particle 72 Neighboring gene phosphoribosyl pyrophosphate amidotransferase Neighboring gene aminoadipate-semialdehyde dehydrogenase Neighboring gene uncharacterized LOC120096736 Neighboring gene capping protein inhibiting regulator of actin dynamics

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Rat genomic structure of amidophosphoribosyltransferase, cDNA sequence of aminoimidazole ribonucleotide carboxylase, and cell cycle-dependent expression of these two physically linked genes. Iwahana H, et al. Biochim Biophys Acta, 1995 Apr 26. PMID 7742366
    2. Nucleotide sequence of a nearly full-length cDNA coding for pepsinogen of rat gastric mucosa. Ichihara Y, et al. Eur J Biochem, 1986 Nov 17. PMID 3780741
    3. Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches. Ikeda M, et al. Biol Psychiatry, 2010 Feb 1. PMID 19850283
    4. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
    5. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Buschow SI, et al. Immunol Cell Biol, 2010 Nov-Dec. PMID 20458337

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93240

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphoribosylaminoimidazole carboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylaminoimidazole carboxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphoribosylaminoimidazole carboxylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' AMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in 'de novo' IMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 'de novo' IMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 'de novo' IMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in 'de novo' XMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in G1/S transition of mitotic cell cycle IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in GMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in purine nucleobase biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in purine nucleobase biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase
    Names
    AIR carboxylase-SAICAR synthetase
    multifunctional protein ADE2
    multifunctional protein ADE2-like
    phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
    phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole succinocarboxamide synthetase
    phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazolesuccinocarboxamide synthase
    phosphoribosylaminoimidazolesuccinocarboxamide synthase
    NP_543186.1
    XP_006250914.1
    XP_006250915.1
    XP_006250916.1
    XP_063128886.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433942.1 → NP_001420871.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      P51583
      UniProtKB/TrEMBL
      A6JCW6, A6JCW8

    2. NM_001433943.1 → NP_001420872.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      P51583
      UniProtKB/TrEMBL
      A6JCW6, A6JCW8

    3. NM_080910.4 → NP_543186.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

      See identical proteins and their annotated locations for NP_543186.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      P51583
      UniProtKB/TrEMBL
      A6JCW6, A6JCW8
      Related
      ENSRNOP00000061495.2, ENSRNOT00000063942.3
      Conserved Domains (2) summary
      cd01416
      Location:7 → 258
      SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
      TIGR01162
      Location:268 → 421
      purE; phosphoribosylaminoimidazole carboxylase, PurE protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      31553355..31586843 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272816.1 → XP_063128886.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X1

      Related
      ENSRNOP00000089961.1, ENSRNOT00000096789.2

    2. XM_006250853.5 → XP_006250915.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X2

      Conserved Domains (2) summary
      cd01416
      Location:7 → 258
      SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
      TIGR01162
      Location:268 → 421
      purE; phosphoribosylaminoimidazole carboxylase, PurE protein

    3. XM_006250854.3 → XP_006250916.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X2

      See identical proteins and their annotated locations for XP_006250916.1

      UniProtKB/Swiss-Prot
      P51583
      UniProtKB/TrEMBL
      A6JCW6, A6JCW8
      Conserved Domains (2) summary
      cd01416
      Location:7 → 258
      SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
      TIGR01162
      Location:268 → 421
      purE; phosphoribosylaminoimidazole carboxylase, PurE protein

    4. XM_006250852.4 → XP_006250914.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X2

      Conserved Domains (2) summary
      cd01416
      Location:7 → 258
      SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
      TIGR01162
      Location:268 → 421
      purE; phosphoribosylaminoimidazole carboxylase, PurE protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51583.3 GenPept UniProtKB/Swiss-Prot:P51583

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